M. Zhang

This study regenerates functional B lymphopoiesis from pluripotent stem cells (PSCs) using Runx1, Hoxa9, and Lhx2, producing antigen-specific antibodies and immune memory in B-cell deficient animals.

This paper develops photosensitized electrospun nanofibrous filters that capture and inactivate airborne coronaviruses under visible light, achieving 99.2% capture and 98.9% inactivation of MHV-A59.

The paper introduces SRS-FISH, a high-throughput imaging method to analyze microbial function at the single-cell level, showing Bacteroidales dominate sugar utilization but Clostridia outperform them in fucose foraging.

The paper screens a fragment-based library to identify inhibitors of Lassa virus endonuclease, finding two benzotriazole compounds that inhibit viral minigenome activity and show synergistic antiviral effects.

This study uses deep metagenomics to explore microbial communities in Challenger Deep sediment, revealing new MAGs, metabolic functions, and virus-host interactions in hadal zone ecosystems.

This study identifies molecular subtypes of prostate cancer using multi-omics data and clustering algorithms, revealing distinct clinical and biological features associated with each subtype.

The paper identifies a new ERGIC-ERES membrane contact mediated by TMED9 and SEC12 that is essential for autophagosome biogenesis under stress.

This study shows a single-dose AAV-based vaccine induces long-lasting neutralizing antibodies against multiple SARS-CoV-2 variants in rhesus macaques.

This study introduces a new microscopy technique combining deep learning and light-sheet design to visualize organelle interactions in live cells with high spatial and temporal resolution.

This study shows that Legionella pneumophila Sde proteins can ubiquitinate tyrosine residues, not just serine, challenging previous assumptions about their substrate specificity.

The paper defines and extends the near-infrared biological window for improved in vivo fluorescence imaging, proposing new regions and demonstrating enhanced imaging capabilities.

This study maps genetic diversity across Zea species, identifying millions of variants and adaptive genes, and demonstrates their utility in breeding.

This study uses molecular dynamics to analyze wild-type and V600E B-Raf, revealing how the mutation affects activation pathways and stabilizes the active state through specific interactions.

This study estimates the de novo mutation rate in pigs using whole-genome sequencing of a three-generation pedigree and revises the evolutionary timeline of pigs, including divergence events and domestication history.

The paper shows that road salt runoff increases pond conductivity, leading to edema and reduced locomotion in wood frogs, with stronger effects in northern populations.

This study identifies SSR1 as a chaperone-like protein that enhances HSCA2-ISU1 interaction in the mitochondrial iron-sulfur cluster biosynthesis pathway, essential for plant mitochondrial function.

The paper introduces site-specific phosphorylations in PSD-95 and shows how they affect phase separation with interaction partners, revealing opposing effects on condensate formation.

The paper introduces a post-processing method to enhance retinal image contrast by optimally combining multi-offset AO ophthalmoscope images.

This study identifies ginsenoside Rg3 as a molecular glue that enhances mitochondrial UPR via the TRKA-GRB2-EVI1-CRLS1 axis to restore proteostasis in Parkinson's disease.

The paper uses cryo-electron tomography to image mitochondria-cytoskeleton interfaces in mammalian sperm, revealing conserved supramolecular arrays composed of glycerol kinase-like proteins.

This study shows that SETD7 methylates KRAS at lysine 182 and 184, promoting its degradation and suppressing RAS/MEK/ERK signaling, thereby acting as a tumor suppressor in NSCLC.

This paper develops an integrated mass spectrometry strategy to analyze the complex glycosylation of erythropoietin, identifying N- and O-glycan structures and their site-specific modifications.

This study shows Bub1 and the CENP-U complex redundantly recruit Plk1 to kinetochores, ensuring accurate chromosome segregation, and suggests potential therapeutic targets for cancer cells with Bub1 or CENP-U mutations.

The paper introduces SPARCLD, a method for parallelized, multi-step liposome fusion using DNA, enabling high-throughput combinatorial screening with minimal material.

This study identifies SlBES1 as a regulator of tomato fruit softening by repressing PMEU1, leading to firmer fruits with extended shelf life without affecting visual or nutritional quality.

This study analyzes the spatio-temporal changes in Nanjing's urban thermal environment from 2014 to 2018 and identifies key driving factors behind these changes.

This study shows that glioma cells depend on exogenous cysteine/cystine, and dietary restriction extends survival in a mouse model, though tumors can later compensate by synthesizing glutathione.