P. Liu

This paper identifies a conserved RNA structure in influenza A virus that mediates packaging and disease, showing that targeting it inhibits virus production and reduces disease severity.

This study identifies two potent monoclonal antibodies against the B.1.351 variant and shows their efficacy against other variants, suggesting their use as an antibody cocktail.

The paper identifies immunosuppressive signatures and functional maturity of fetal immune cells in human placental villi across gestational ages.

This study identifies PPP1R14C as a driver of triple-negative breast cancer progression by inactivating GSK3β through PP1 inhibition and TRIM25-mediated degradation of non-phosphorylated GSK3β.

The paper identifies beneficial and detrimental bacteria affecting sorghum drought responses using lab, transitional, and field experiments.

This paper improves prime editors for genome editing in adult mice, enabling pathogenic mutation correction and cancer modeling.

This study quantifies the funny current (If) in murine sinoatrial node myocytes, showing its persistent activity and dual role in driving membrane potential oscillations during pacemaking.

This study uses mass cytometry to analyze immunological changes in mice after radiation-induced cardiac fibrosis, finding increased macrophages and pro-fibrotic cytokines.

This paper introduces a rapid method for sample partitioning into microwells for digital bioassays, achieving high-density arrays with over 100,000 wells in under 30 seconds.

The paper identifies mutation-specific pathophysiological mechanisms in SATB1 variants causing distinct neurodevelopmental disorders.

This study identifies the structural and molecular mechanisms of two neutralizing antibodies against FMDV, showing they disrupt virus-receptor interactions and provide prophylactic and therapeutic benefits.

This study characterizes the dynamic changes in B-cell receptor repertoires of COVID-19 patients using next-generation sequencing, revealing clonotype overlap, lineage expansion, and V gene usage patterns.

This study compares the molecular mechanisms of pluripotent reprogramming and malignant transformation, revealing shared and distinct features of cellular plasticity and identifying bHLH transcription factors as key regulators.

The paper generates a single-cell atlas of pig lung using scRNA-seq and develops an online platform to explore lung single-cell data across species.

hAd5 spike + nucleocapsid SC prime/oral boost vaccine elicits humoral and T-cell responses and protects rhesus macaques from SARS-CoV-2 challenge.

The paper shows that ATF-4 and hydrogen sulfide signaling mediate longevity from translation or mTORC1 inhibition in C. elegans.

This paper describes a method to fabricate and characterize free-standing asymmetric membranes and finds that increasing anionic lipid concentration increases membrane thickness and stiffness.

This paper develops a high-throughput experimental evolution system in yeast using genetic barcoding to measure fitness and adaptation across multiple populations and conditions.

The paper shows ATFS-1 promotes {Delta}mtDNA replication by recruiting POLG, while LONP-1 inhibition increases wildtype mtDNA binding and improves heteroplasmy ratio and OXPHOS function.

This study examines how SARS-CoV-2 mutations affect protein structures and intraviral interactions, identifying mutations that cause structural changes and alter binding affinity and hot spots.

This paper characterizes a new microtubule-targeting compound, C75, which disrupts mitotic spindle poles and causes mitotic arrest in cancer cells.

The paper designs ACE2-Fc variants with lost enzymatic activity but retained antiviral function to avoid cardiovascular side effects.

This paper introduces a method to identify microbiome features affecting outcomes while controlling for confounding variables, showing improved accuracy in agricultural microbiome studies.

DRAM automates microbiome function curation by translating genomic data into microbial traits, accurately assigning metabolic roles in soil and gut communities.

This study generates and tests human embryonic stem cell-derived immunity-and-matrix-regulatory cells (IMRCs) for treating lung injury and fibrosis in mice, showing efficacy and safety.

This study shows fibroblasts can modulate the immune system and treat EAE, a multiple sclerosis model, by inhibiting T cell activation and promoting Treg cells, suggesting their potential as an alternative to MSCs.

This paper introduces a human primary airway epithelial cell-based model for evaluating influenza and coronavirus infections in vitro, demonstrating its ability to assess viral infection kinetics and therapeutic efficacy.

The paper identifies lipid droplets in multiple bacterial phyla, shows their conservation and inheritance, and estimates their origin to 3.19 billion years ago.

This study infects hACE2 transgenic mice with SARS-CoV-2 and observes pathogenic effects, confirming Koch's postulates and establishing a model for vaccine and therapeutic development.