P. Liu

The paper identifies lipid droplet-like structures in gut microbiota from mouse and human samples and establishes a method to study them.

This study identifies Rab18's role in lipid droplet dynamics by showing it binds PLIN2 and ACSL3, promoting TAG accumulation and LD growth in muscle cells.

The paper studies the binding and enzymatic activity of LD proteins using adiposomes, showing PI's effect on PLIN2 and ATGL.

This study uses synchrotron soft X-ray nano-computed tomography to quantitatively image the 3D ultrastructure of intact anammox bacteria and explores their shape adaptation to Fe2+.

The paper identifies noncoding RNA-encoded proteins on lipid droplets, discovering LDANP1 which modulates lipid metabolism and insulin sensitivity.

The paper investigates how lipid droplet-anchored mitochondria in brown adipocytes respond to cold temperatures and identifies differences in protein expression between these mitochondria and cytoplasmic mitochondria.

The paper designs a soluble ANGPT1 mimetic, C4BP-ANG1, which activates Tie2 and reduces vascular leakage in models of inflammation.

This paper identifies a novel protein complex in Arabidopsis that regulates ROS1-mediated active DNA demethylation and targets ROS1 to specific genomic regions.

This study analyzes pangolin coronaviruses to assess their role as potential intermediate hosts of SARS-CoV-2, finding genetic relatedness but not direct origin.

This study shows that a diversified learning environment improves active avoidance learning and mitigates stress-induced learning impairments in animals.

This study shows that CTR9 loss in breast cancer cells increases H3K27me3 levels and switches PRC2 subtype, making cells more sensitive to PRC2 inhibitors.

This study identifies NMD-escape fs-indels as a biomarker associated with improved response to immunotherapy in melanoma patients.

This study evaluates two tDCS optimization schemes for single and multi-target brain stimulation, showing that parameter settings significantly affect outcomes, especially in multi-target cases, and proposes improved weighted schemes.

The paper generates a comprehensive Arabidopsis proteome atlas and library, then uses DIA-MS to study abscisic acid effects, identifying differentially expressed proteins.

This study shows that inhibiting GMP synthesis extends yeast replicative lifespan through a mechanism independent of known nutrient-sensing and sirtuin pathways.

This paper describes the synthesis of cyclopentadecanone and cyclopentadecanolide from Malania oleifera Chum oil through ozonolysis, esterification, and cyclization reactions with reported yields.

This study investigates how histone post-translational modifications affect mitotic chromosome stiffness using force measurements and epigenetic drugs, finding that methylation, not acetylation, contributes to mitotic structure.

The paper traces the origins of beer yeasts to admixture between European and Asian wine yeast populations, revealing a polyploid origin and genetic diversity from extinct or uncharacterized sources.

The paper shows dietary fatty acids influence lipid droplet diversity via SEIP-1 enrichment in an ER subdomain in C. elegans and mammalian cells.

This paper demonstrates three-photon light-sheet fluorescence microscopy, enhancing penetration depth using Bessel beams for imaging cellular spheroids.

This paper generates a mouse model with a conditional knock-in of the U2af1(S34F) mutation to study its role in hematopoiesis and leukemia, finding that it requires additional mutations for leukemogenesis.

This study shows that reducing C/EBPβ-LIP expression in mice delays age-related phenotypes and extends lifespan, suggesting therapeutic potential for age-related diseases.

This study identifies natural variation in OsLG3 that enhances drought stress tolerance in rice by improving ROS scavenging, offering a genetic resource for breeding drought-tolerant rice.

The paper shows that DARPP-32 and t-DARPP promote lung cancer growth via IKKα-dependent migration and Akt/Erk-mediated survival, with t-DARPP linked to poor survival and higher tumor stages.

This study identifies BCL11A as an oncogene in lung squamous cell carcinoma, showing its interaction with SOX2 to regulate epigenetic factors and demonstrating potential therapeutic targets.