P. Wang

This study characterizes an attenuated SARS-CoV-2 variant with a deletion at the S1/S2 junction, showing reduced pathogenicity and immunogenicity but strong protective immunity.

The paper observes mitochondrial biogenesis as an early event preceding radiation-induced apoptosis in living cells using a dual fluorescence reporter system.

This study develops a machine learning model to predict genetic redundancy in Arabidopsis thaliana using diverse features, identifying key predictors like recent duplication and stress-related expression.

This study identifies NSP8 as a SARS-CoV-2 protein that suppresses MDA5-mediated antiviral immune responses by inhibiting type I IFN signaling.

This paper develops a mouse model of prostatic inflammation and collagen accumulation using E. coli UTI89 instillations to study aberrant collagen production in the prostate.

This study shows a combination of DYRK1A inhibitor and GLP1R agonist increases human beta cell mass in vivo by 400-700% in mice, using iDISCO+ 3D imaging for quantification.

This study screens a botanical drug library to identify inhibitors of Lassa virus entry, finding two compounds with distinct mechanisms of action.

The paper isolates and characterizes 61 SARS-CoV-2-neutralizing monoclonal antibodies from infected patients, identifying potent antibodies targeting multiple epitopes on the spike protein.

The paper analyzes CITEseq data from NSCLC lesions to identify an immune cell activation module linked to tumor antigen load and TP53 mutations.

This study predicts plant metabolic pathway memberships using gene expression data and machine learning, finding that unsupervised learning and expression similarity outperform naive methods in some cases.

The paper analyzes metabolic diversity in mononuclear phagocytes across tissues using integrated datasets and a network-based approach, identifying key metabolic subnetworks and their functional roles.

The paper shows that modulating Siglec-7 signaling via high-affinity cis-ligands on NK cells can suppress or enhance NK cytotoxicity depending on ligand concentration.

This paper improves an adenine base editor for in vivo use, achieving efficient dystrophin restoration in dystrophic mice with minimal off-target effects.

The paper develops biotin-labeled SARS-CoV-2 spike molecular probes using structure-based design and purification methods, achieving high yields and enabling antibody characterization.

This study shows that MSR1 promotes VSV infection in the spinal cord by acting as a receptor, and its absence reduces viral load and mortality in mice.

This study identifies novel transcription terminators in maize that enhance transgene expression by overlapping poly(A) signals, with specific motifs like AUGAAU showing functional significance.

This study identifies two bacterial lipases with broad-spectrum antiviral activity against multiple enveloped viruses, including SARS-CoV-2, by disrupting viral envelopes.

This study shows that STING deficiency increases CXCL10 expression, leading to higher viral loads and inflammation in alphavirus-induced arthritis in mice.

This study shows filamentous recombinant human Tau activates astrocytes via integrin V/{beta}1 receptor, leading to neurotoxic effects through NF{kappa}B signaling.

This study identifies PDE6D as a potential target of sorafenib using PROTAC technology and proteomic analysis.

This study uses hPSC-derived lung organoids to identify FDA-approved drugs that inhibit SARS-CoV-2 entry and reduce infection in a model of human COVID-19.

This study uses human pluripotent stem cell-derived colonic organoids to identify drugs that block SARS-CoV-2 infection, finding mycophenolic acid and quinacrine dihydrochloride effective in vitro and in vivo.

This study shows pen-strep increases macrophage stiffness and promotes cell spreading on various ECM substrates through YAP-1/TAZ upregulation and β1 integrin downregulation.

This paper develops microbial strains for producing renewable fatty acid esters, achieving high yields and economic competitiveness in bioproduction.

The paper develops a sandwich ELISA method using monoclonal antibodies to detect pre-proinsulin in recombinant human insulin production.

This study shows that SARS-CoV-2 nucleocapsid protein reduces pluripotency in human iPSCs, causing them to lose differentiation ability and adopt fibroblast-like morphology.

This study modifies NK cells with CD22 and selectin glycan ligands to enhance B-cell lymphoma targeting and trafficking, achieving effective tumor suppression in a xenograft model.

This study shows that high concentrations of angiotensin II induce apoptosis in human iPSC-derived cardiomyocytes after long-term exposure.

This study evaluates the in vivo efficacy and PK/PD of KBP-7072, an aminomethylcycline antibiotic, in pneumonia and thigh infection models, showing significant dose-dependent reductions in CFUs and improved survival.