P. Wang

This paper describes the development of DN052, a novel TLR8 agonist with high potency and selectivity, showing strong antitumor activity and favorable safety profile, leading to phase I clinical trials.

This study investigates the role of reactive oxygen species (ROS) in plant cell division and cold stress adaptation, finding that ROS influence cell wall stiffness and regulate division rates in Brassica napus.

The paper studies the evolution of a gene cluster in Solanaceae plants and its role in producing medium chain acylsugars through trichome-specific enzymes.

This paper identifies a novel bat coronavirus, RmYN02, with sequence similarities to HCoV-19 and natural insertions at the S1/S2 cleavage site, suggesting a possible recombinant origin for HCoV-19.

The paper uses cryo-EM to reveal the post-fusion structure of SARS-CoV-2, showing the S protein in a state with S1 disassociated.

The paper shows dietary glucose promotes Plasmodium infection by expanding a gut bacterium that alkalizes mosquito midgut, enhancing parasite development.

This study identifies differential host gene signatures in response to various Mycobacterium tuberculosis strains, highlighting distinct immune responses associated with isoniazid resistance.

This study investigates how antler polypeptide affects the proliferation and osteogenic differentiation of rat bone marrow mesenchymal stem cells, finding that antler polypeptide B significantly enhances these processes.

The paper uses BioID to identify novel Bid interactors involved in cell cycle-dependent apoptotic priming, highlighting VDAC2's role in Bid phosphorylation and sensitivity to anti-mitotic drugs.

This study identifies NUP210 as a metastasis susceptibility gene in ER+ breast cancer, showing its role in mechanosensation through heterochromatin-mediated disruption of mechanotransduction.

The paper introduces a deep learning method to predict virus hosts using DNA sequences, applied to 2019-nCoV to identify potential hosts like bats and minks.

The paper uses transfer learning to predict specialized metabolism genes in tomato by leveraging annotations from Arabidopsis thaliana, improving prediction accuracy.

This study compares gut microbiota composition between healthy and rotten-skin diseased giant spiny frogs using 16S rRNA sequencing and identifies significant microbial abundance differences.

This study identifies Lyn-dependent secretory autophagosomes as a novel pathway for flavivirus secretion, enabling evasion of antibodies and tissue tropism.

This study shows IL-12 enhances B16F0 melanoma cell survival through non-canonical PI3K-AKT signaling, distinct from its canonical role in immune cells.

The paper develops a pseudoislet system to study GPCR signaling differences between human α and β cells, showing distinct effects of Gi and Gq pathway activations on hormone secretion.

This study compares bacterial diversity in raw and pasteurized goat milk using high-throughput sequencing, identifying new bacterial species and viable but nonculturable bacteria.

This study shows that bacterial flagella are not permanent structures, dynamically produced and lost during growth phases, with glucose availability influencing their disassembly.

This study shows that combining sirolimus and nintedanib treats vascular abnormalities in HHT mouse models by targeting multiple pathways.

This study shows that soil chloride content affects bacterial but not fungal diversity when exposed to wastewater treatment processed silver nanoparticles.

This study examines how antibiotic exposure affects intracellular and extracellular ARG abundance in AnMBR effluent, finding that exARGs on small plasmids are preferentially taken up.

This study examines the assembly properties of SyFtsZ from Synechocystis sp. PCC 6803, identifying different protofilament structures formed in GTP and GDP conditions.

This study identifies eCIRP as a novel TREM-1 ligand that drives inflammation in sepsis and develops a peptide M3 to block this interaction and improve outcomes.

This study uses circadian time-series proteomics to identify daily protein abundance changes in mouse articular cartilage, revealing rhythmic proteins and their dysregulation in osteoarthritis and aging.

This study evaluates how prostate mass and testosterone affect voiding function in male and female mice, finding that testosterone, not prostate size, primarily drives sex differences in urinary function.

The paper optimizes a steroid-inducible gene expression system for rice, showing high sensitivity but off-target effects that can be mitigated with IPTG.

This study examines the effects of carbon nanotubes and graphene oxide derivatives on soil bacterial diversity using 16S rRNA sequencing across different concentrations and time points.

This paper investigates the health communication behavior of Chinese doctors on online media, finding that their involvement is low and influenced by media use and self-efficacy.

This study shows that formaldehyde inhibits osteoblast proliferation and migration via the FoxO1 signaling pathway in mouse cells.

This study examines the effects of graphene oxide and graphite on soil microbial communities, finding that both alter community composition but not alpha diversity.