Q. Li

This study shows human microglia can be reconstituted in the brain of hu-BLT mice with hIL34 transgene and support HIV-1 infection, highlighting their role in CNS HIV-1 pathogenesis.

This study identifies TiAP1 from Thinopyrum intermedium as a resistance gene against Blumeria graminis f. sp. tritici, showing it interacts with BgtCDA1 and enhances wheat resistance through immune activation.

This study evaluates a recombinant chimpanzee adenovirus vaccine expressing a dimeric tandem-repeat RBD of SARS-CoV-2, showing enhanced immune responses and protection in mice.

This study identifies and characterizes the genetic structure and evolutionary relationships of CPS loci in 40 K-serogroups of Vibrio parahaemolyticus using whole genome sequencing of 443 strains.

The paper examines HDP gene expression and tissue distribution in different chicken breeds, finding correlations between body weight, age, and HDP expression in immune organs and intestine.

Biochemical and transgenic analyses reveal that Petunia hybrida S3-RNase cytotoxicity is largely restricted by a stepwise ubiquitination and degradation pathway during cross-pollination.

The paper determines the cryo-EM structure of TDP-43 low complexity domain amyloid fibrils, revealing a distinct core structure compared to shorter fragments.

This paper identifies and characterizes a potent human monoclonal antibody, HB27, that blocks SARS-CoV-2 receptor binding and membrane fusion, showing protective effects in mice and non-adverse effects in rhesus macaques.

This study identifies the GEMC1-MCIDAS transcriptional program as essential for multiciliogenesis in the choroid plexus and its role in preventing tumorigenesis.

This study introduces a fast lysine cross-linker DOPA for mass spectrometry analyses, showing it enables rapid protein cross-linking and captures dynamic conformational changes and weak protein-protein interactions.

This study shows that laccase genes are essential for root development and phenolic acid metabolism in Salvia miltiorrhiza using CRISPR/Cas9 gene knockout.

CancerVar scores and classifies somatic mutations into four tiers using a rule-based system and a deep learning model, improving interpretation of both known and novel mutations in cancer.

A potent neutralizing antibody protected against SARS-CoV-2 in an hACE2 mouse model by blocking viral receptor interaction.

The paper identifies a diamide inhibitor of Streptococcus pneumoniae growth and shows that genetic and chemical inactivation of autolysins yield different phenotypic outcomes.

The paper analyzes mutation spectra and compositional variability in SARS-CoV-2 clades to understand mutation patterns and their implications for viral proteomes.

The paper shows that KDM3A and KDM3B, along with OCT4/SOX2, regulate H3K9 methylation to maintain pluripotency in porcine-induced pluripotent stem cells.

The paper identifies humoral immune responses to SARS-CoV-2 and other human coronaviruses peptides to detect infections and discover immunity biomarkers.

This study shows an inactivated SARS-CoV-2 vaccine induces neutralizing antibodies and CTL responses in rhesus macaques, effectively preventing viral replication and lung inflammation.

This study uses computational modeling to show that reducing IK1 and increasing If in ventricular myocytes can generate stable pacemaking activity, providing a theoretical basis for engineered biological pacemakers.

This study integrates proteomic data from human and mouse macrophages to analyze posttranslational modifications in the inflammatory response, identifying PTM crosstalk and novel inflammatory proteins.

This study investigates how the marine ciliate Mesodinium rubrum controls sequestered cryptophyte organelles, finding limited transcriptional control and significant gene expression from the prey.

This paper examines the theoretical basis of two DNA polymerase fidelity assays and shows they only accurately quantify proofreading efficiency under specific kinetic parameter constraints.

The paper identifies FMN1 as a driver of glioblastoma invasiveness by linking it to increased cell stiffness, mechanical forces, and stochastic motility.

This study shows that oral administration of a single nanobody provides broad protection against multiple ETEC strains by targeting conserved epitopes.

This study shows that Alk1 mutant endothelial cells expand clonally in mouse brain arteriovenous malformations (AVMs) and that BM-derived Alk1 mutant ECs can cause AVMs.

This study compares gene expression in the small intestine and colon of vitamin A deficient mice, identifying distinct transcriptional responses and novel VA-regulated genes.

This study identifies an IgA monoclonal antibody that blocks SARS-CoV-2 Spike-ACE2 interaction and provides mucosal immunity.

The paper shows that Par-3 and dynein mediate polarized endosome movement during asymmetric division, leading to Notch signaling asymmetry in daughter cells.