S. Zhang

This paper develops a method to measure cell membrane micromechanics using fluorescence lifetime imaging of DiI, enabling analysis of lipid bilayer properties in situ.

This study shows that Syt-7 enhances calcium sensing and delays content release in chromaffin cell vesicles, sustaining secretion during prolonged stimulation.

The paper shows Bcl-2 and Bcl-xL reduce autophagic cell death in polyploid cells treated with Aurora-B kinase inhibitors, contributing to resistance to these drugs.

The paper identifies phosphoprotein biomarkers for Cdk5 activity in neuroendocrine tumors and shows their predictive value for anti-Cdk5 therapy.

This paper introduces CATE-seq, a CRISPR-based targeted sequencing method that outperforms hybridization-based techniques in simplicity, specificity, sensitivity, throughput, and scalability.

This study identifies Rab11b as a mediator of breast cancer brain metastasis by promoting integrin recycling and mechanotransduction.

The paper shows RanGTP creates an effector gradient of XCTK2 and importin α/β that regulates spindle microtubule cross-linking by modulating XCTK2 activity.

This study develops a mouse model of recurrent myocardial infarction and finds that prior MI reduces emergency hematopoiesis and immune response to subsequent cardiac injury.

This study shows that TIGIT-Ig treatment delays lupus onset, reduces autoantibodies, and improves survival in mice, suggesting potential for human autoimmune disease therapy.

This paper introduces a new LC/MS-based RNA sequencing method that directly analyzes multiple-base modifications in RNA mixtures, enabling accurate sequencing and quantification of both canonical and noncanonical bases.

The paper introduces a presuppositionless method to analyze single nanoparticle trajectories by leveraging their historical data, revealing spatiotemporal patterns without predefined models.

This paper describes the de novo formation of organelles in a cyanobacterium, leading to its transition into a eukaryotic alga, and suggests implications for cancer and evolutionary biology.

The paper investigates the evolutionary origin of Hairless in the Notch pathway, showing that direct co-repressor recruitment is ancestral in protostomes and that Hairless evolved from an ancestral MTA gene through duplication.

This paper develops a chemically defined, albumin-free method to produce enucleated red blood cells from human iPSCs, achieving up to 50% enucleated cell yield.

This study quantifies the biomechanics of schistosome locomotion in different physical environments and identifies key motility parameters that could inform drug development.

This paper introduces tunable optical elements for terahertz circular dichroism spectroscopy, enabling dynamic polarization modulation of THz radiation through mechanical strain.

This study screens 15 flame retardants using freshwater planarians to assess neurotoxicity, finding 11 compounds caused adverse effects in both adults and developing organisms, with OPFRs showing comparable toxicity to phased-out BFRs.

The paper introduces RpsA mutations Δ438A and D123A into M. tuberculosis to confirm their role in pyrazinamide resistance.

This study investigates how a breast cancer GWAS variant may regulate immune cell gene expression in the tumor microenvironment, potentially affecting cancer progression.

This paper shows that both fallopian tube and ovarian surface epithelium can originate high grade serous ovarian carcinoma, with distinct biological properties and therapeutic responses.

This study uses vnOCT to detect early retinal changes in a dexamethasone-induced ocular hypertension mouse model, finding that VN ratio and A-V sO2 correlate with RGC loss independent of IOP.

This study identifies the interactome of polyQ-ataxin-1 and shows it disrupts nuclear transport pathways by recruiting nucleoporin Nup98 into nuclear bodies.

The paper presents cryo-EM structures of the human 26S proteasome in seven conformational states during polyubiquitylated protein degradation, revealing dynamic substrate-proteasome interactions and ATP hydrolysis mechanisms.

This study examines how NaCl stress affects exogenous insecticidal protein expression in Bt cotton and its impact on Helicoverpa armigera larvae feeding behavior and nutritional parameters.

The paper identifies molecular subtypes of bronchial premalignant lesions and links immune alterations to their progression to lung cancer.

The paper characterizes RhoGEF/RhoGAP substrate specificities, localization, and interactomes to reveal their role in spatially organizing Rho signaling.

This study shows that circadian rhythms affect lung inflammation during influenza infection by influencing immune cell composition rather than viral replication.

The paper combines proteomics and machine learning to generate a high-confidence apicoplast proteome in malaria parasites, identifying 346 proteins and validating novel functions.

The paper develops a workflow for preparing micro/nano-crystals for MicroED, enabling the study of small macromolecular crystals previously unsuitable for this technique.