T. Li

This study examines the kinetic response of B-cell receptor (BCR) repertoire diversity and lineage expansion in non-human primates after TLR7/8 stimulation, finding that TLR7/8 selectively expands high-mutation, low-frequency IgKL lineages.

This paper demonstrates that mass photometry can rapidly and accurately characterize rAAV vectors by resolving capsid populations and quantifying full and empty capsids.

This study shows R13, a TrkB agonist, improves mitochondrial function and reduces AD-related pathology in 5xFAD mice by enhancing biogenesis and metabolism.

This study shows that colonic epithelial cells adapt to EGFR-independent growth, leading to chromosomal instability and accelerated by prior injury, without introducing cancer driver mutations.

This study examines co-infection and secondary infection rates in COVID-19 patients, finding low rates of Streptococcus pneumoniae co-infections and common secondary pathogens like S. maltophilia.

The paper functionally and antigenically characterizes the hemagglutinin and neuraminidase of Wuhan spiny eel influenza virus to assess its status as a bona fide influenza virus.

The paper examines HDP gene expression and tissue distribution in different chicken breeds, finding correlations between body weight, age, and HDP expression in immune organs and intestine.

This paper develops a hybrid alphavirus-SARS-CoV-2 particle for rapid in vitro screening of neutralizing antibodies, viral variants, and antiviral drugs, showing increased infectivity of variants and enhanced neutralization by post-vaccination serum.

The paper quantifies the phase separation properties of chromatin-associated proteins using an anti-1,6-hexanediol index and shows functional correlations with chromatin organization.

This paper introduces a humanized animal model using patient-derived xenografts to study myeloproliferative neoplasms and identify therapeutic vulnerabilities.

This study shows NMNH enhances NAD+ and inhibits glycolysis, TCA cycle, and cell growth, but does not affect mice.

The paper identifies cross-reactive CD8+ T cell receptors with high functional avidity to a SARS-CoV-2 epitope and its variants, showing their ability to activate and kill infected cells.

The paper describes the biosynthesis of new cinnamid and rosmarinic acid-derived compounds in E. coli that inhibit Leishmania amazonensis arginase, with some compounds showing micromolar inhibition.

This study evaluates two adenovirus vectored COVID-19 vaccines in mice and macaques, showing strong immune responses after prime-boost vaccination.

This study shows that deleting Slc26a9 in parietal cells of mice leads to spontaneous gastric cancer and identifies molecular mechanisms involved in tumor progression.

This study shows SARS-CoV-2 and GX_P2V can infect human endoderm, ectoderm, and lung progenitor cells derived from hESCs, with some infections blocked by whey protein and Remdesivir.

This study identifies a high-affinity nanobody that, when fused to other nanobodies, enhances their potency against SARS-CoV-2 by improving RBD binding without disrupting RBM conformation.

This study identifies a linear epitope on SARS-CoV-2 S-RBD recognized by a potent neutralizing antibody and shows its potential for vaccine design.

This paper demonstrates that engineered T cell libraries with CAR constructs can recognize nonself-antigens, expand clonally, persist, and show immunologic memory against tumors in murine models.

This paper introduces a rapid screening system to identify potent neutralizing antibodies against SARS-CoV-2 and demonstrates its effectiveness in discovering high-potency antibodies.

This study shows that low-passage dengue virus isolates preserve the consensus sequence and intra-host variant frequencies of their clinical samples, making them suitable for genomic epidemiology.

This study shows that whey protein from human and other animal milk inhibits SARS-CoV-2 and GX_P2V in vitro by blocking viral attachment, entry, and replication.

This paper identifies a ZIKV mutation, M1404I, that enhances fetal infection in mice but reduces viral fitness and transmissibility in nonpregnant macaques and mosquitoes.

This paper introduces a technique combining label-free histology with spatially resolved multi-omics to map gene expression and copy number alterations in human oral squamous cell carcinoma.

This study genetically modifies human macrophages with CARs to target SARS-CoV-2, showing that CARMERTK macrophages reduce viral load without increasing proinflammatory cytokines.

This study identifies gut microbiota changes and their associations with cerebral cortex and cerebrovascular abnormalities in human mild traumatic brain injury.

The paper compares the transcriptional responses of controlled and natural primary DENV-1 infections using scRNA-seq, finding similar inflammatory responses but more pronounced suppression of translation and mitochondrial function in natural infections.

The paper isolates and characterizes a new sulfate-reducing bacterium from the human gut that can fix nitrogen, naming it Desulfovibrio diazotrophica.

This study shows that exogenous melatonin administration restores diurnal rhythms in gut microbiota and host metabolism in high fat diet-fed mice.