W. Xu

This study identifies how coronaviruses like PEDV and SARS-CoV-2 evade antiviral responses by manipulating caspase-1 and inhibiting IFN-I signaling through proteolytic activities.

The paper shows a toxin-antidote element in C. elegans provides a fitness benefit to hosts, explaining its prevalence despite minimal gene drive.

This study investigates TANGO2 deficiency in iPSC-derived cardiomyocytes and fibroblasts, finding no defects in mitochondrial OXPHOS function under baseline or fasting conditions.

The paper identifies three deeply conserved super-enhancers in placental mammals that are essential for maintaining stem cell pluripotency.

This study shows that asymmetric ABA response in tomato root tips mediates proton efflux and cell elongation, driving hydrotropic bending toward water.

This study evaluates the neutralization efficacy of antibodies against SARS-CoV-2 Omicron and other variants, finding that antibody 8G3 maintains broad neutralizing activity while EUA antibodies lose effectiveness.

This study develops two ERR agonists that improve heart failure by enhancing fatty acid metabolism and mitochondrial function in mice.

This study shows that bile acids impair CD4+ T cell activation in cholestasis, worsening HBV infection outcomes by disrupting calcium signaling and metabolic reprogramming.

This study evaluates ACE2-Fc combined with neutralizing antibodies against SARS-CoV-2 variants, showing enhanced neutralization and resistance to escape mutations.

This paper introduces a topological supramolecular network strategy to create highly conductive and stretchable organic bioelectronics with unprecedented performance in physiological environments.

The paper introduces a time-resolved statistical method to analyze the evolutionary dynamics of SARS-CoV-2 spike mutations and quantifies mutation strength using the L-index.

The paper develops a method to classify preeclamptic and normotensive placental extracellular vesicles using nanoplasmonic sensors and machine learning.

The paper introduces Yn situ, a single RNA molecule in situ detection method, showing it is sensitive and quantitative for gene expression in mouse olfactory epithelia.

The paper identifies SeASF1 and SeH4 as regulators of the PI3K/AKT pathway in filamentous ascomycete, influencing sexual and asexual development through interactions with SeDJ-1 and SePI3K.

This paper identifies a monoclonal antibody, 2G1, that neutralizes all SARS-CoV-2 variants with high potency and describes its mechanism of action and therapeutic efficacy in animal models.

This paper shows that combining disulfiram and copper(II) gluconate significantly enhances anti-SARS-CoV-2 activity in vitro compared to either compound alone.

This study identifies a non-bactericidal cathelicidin, PopuCATH, that prevents bacterial infection by enhancing phagocyte influx and reducing inflammation without direct antimicrobial activity.

The paper reveals how assembly status transitions in glutamine synthetase modulate enzymatic activity through dynamic allosteric regulation.

This study characterizes the ubiquitin-ESCRT pathway in Asgard archaea, showing its pre-eukaryotic origin and evolutionary path through gene duplication.

This study identifies SYVN1 as an E3 ubiquitin ligase that promotes GSDMD-mediated pyroptosis by ubiquitinating GSDMD at specific residues.

The paper identifies non-reproducible antibody-antigen interactions in clinical sera and develops a model to explain them, improving serological testing for viral infections like COVID-19.

This study identifies plakoglobin and HMGB1 as key mediators of TcdB-induced intestinal epithelial cell apoptosis through mitochondrial pathways.

This study identifies Tcfl5 as a testis-specific protein essential for male fertility, showing that heterozygous mice are infertile and exhibit abnormalities in spermatids and spermatozoa.

The paper shows lung epithelial cells can produce TD-Ag-specific antibodies, dependent on CD4+ T cells, challenging the notion that B cells are the sole source of such antibodies.

The paper performs meta- and mega-analyses of fecal metagenomic data from four cohorts to identify bacterial species associated with response to immune checkpoint inhibitors.

This study identifies three ultrapotent SARS-CoV-2 neutralizing antibodies effective against B.1.351 variants, showing synergistic effects and protective efficacy in mice.

This paper discovers CIPS nanosheets that selectively bind SARS-CoV-2 spike protein, inhibit viral entry, and promote macrophage-mediated viral elimination.

This study identifies that SARS-CoV-2 nucleocapsid protein undergoes phase separation, which can be modulated by small molecules, offering new therapeutic strategies against COVID-19.

This study identifies SNHG16 as a promoter of renal cell carcinoma proliferation and inhibitor of apoptosis through the miR-1301-3p/STARD9 axis.