W. Yang

This study shows that the MNK1/2-eIF4E axis promotes immune suppression and metastasis in postpartum breast cancer by affecting both tumor and non-tumor cells.

The paper identifies public antibody clones in the human repertoire, including virus-neutralizing and anti-PD1 clones, and introduces a tool for analyzing Rep-seq data.

This study shows an inactivated SARS-CoV-2 vaccine induces neutralizing antibodies and CTL responses in rhesus macaques, effectively preventing viral replication and lung inflammation.

The paper investigates how DNA sequence arrangements influence the structural organization of nucleoprotein complexes formed by FIS and H-NS in bacteria.

This study identifies the MNK1/2-eIF4E axis as a driver of melanoma phenotype switching, progression, and immunotherapy resistance, with potential therapeutic targeting.

This study identifies RIPK2 as a target for inhibiting prostate cancer metastasis by stabilizing c-Myc and shows its suppression reduces disease progression.

The paper introduces a method to improve pathogen detection in metagenomic data by correcting abundance estimates using species-specific genomic regions, enhancing sensitivity and specificity for low-abundance pathogens.

The paper identifies an immunosuppression signature (IMS) and shows that its ratio to an IFN-γ signature better predicts anti-PD-1 therapy response in melanoma than existing biomarkers.

This study identifies humanized single domain antibodies that neutralize SARS-CoV-2 by targeting the spike receptor binding domain, showing improved activity when fused with the Fc region.

The paper identifies a germline non-coding GATA3 variant that alters chromatin topology and contributes to Ph-like ALL by activating an enhancer and reshaping 3D genome organization.

This study shows that hexaploidization in wheat enhances genetic recombination of the ancestral diploid genome, increasing evolutionary potential and aiding wheat's global spread.

This paper characterizes the kinetics of the radical-mediated C-C bond formation in MoaA, revealing a shunt pathway and determining the rate of the 3',8-cyclization step.

This study identifies and validates a core regulatory circuitry trio in Ewing sarcoma, showing how EWS-FLI1 and CRC factors regulate transcription and epigenome, with implications for therapy.

This study identifies copper hijacking by Sclerotinia sclerotiorum during infection and shows host resistance mechanisms involving copper homeostasis.

This study shows that flattened diurnal glucocorticoid oscillations lead to obesity and diabetes by dysregulating lipid metabolism via Cd36 and insulin signaling in adipose tissues.

This study develops dihydroartemisinin-loaded magnetic nanoparticles to enhance chemodynamic therapy, showing improved ROS production and efficacy against breast cancer cells, including drug-resistant ones.

This study shows that high light and elevated temperature reduce certain glucosinolates but increase health-promoting metabolites in kale varieties.

This study analyzes 2,152 antibody repertoires to identify key features of B cell biology, revealing gene usage patterns, sex preferences, and mutability mechanisms in the antibody repertoire.

This study identifies distinct palmitoyl-protein signatures in large and small cancer-derived extracellular vesicles using a novel proteomic approach.

This study examines changes in IL-10 expression in myocardial infarction and its association with macrophage activation and cardiomyocyte apoptosis over time.

This study shows that neogambogic acid inhibits osteosarcoma by targeting the USP9x/SOX2 axis through ubiquitin proteasome-mediated degradation of SOX2.

The paper identifies two new transport pathways in primary cilia - passive diffusion and vesicle transport - using single molecule microscopy in live cells.

This study identifies ALI-1 as a candidate gene for the B1 locus, showing its role in regulating awn length and grain weight in wheat through cytokinin suppression.

This study introduces a method using a single FT expression cassette in CRISPR/Cas9 to rapidly generate and identify transgene-free mutants in Arabidopsis.

The paper shows Tyr1 phosphorylation directs P-TEFb to phosphorylate Ser2 on RNA polymerase II CTD, altering its specificity and expanding CTD modification coding potential.

This study identifies a Clostridia-rich microbiota as a contributor to excessive bile acid excretion in IBS-D patients through metagenomic and metabolomic analyses.

The paper introduces a modified ABE method that reduces background noise in S-acylproteomic analysis, enabling the identification of 2,895 high-confidence S-acylated proteins in human prostate cancer cells.

The paper analyzes the metabolic capabilities of the native microbiome of C. elegans and shows it can synthesize all essential nutrients for the nematode.

This study investigates how C. elegans responds to its native microbiome across development and adult life, identifying key molecular processes and regulatory mechanisms.

This study identifies a metal-dependent regulatory mechanism in PfA-M17 aminopeptidase, showing how oligomerization and metal center re-modelling control proteolytic activity.