X. He

This study reports the formation mechanism of twinning β-form anhydrous guanine microplatelets in scallop eyes, revealing an intermediate amorphous phase and a two-step crystallization process.

The paper reports cryo-EM structures of PTH1R bound to PTH and PTHrP, revealing molecular mechanisms of hormone recognition and selectivity.

This study reports cryo-EM structures of all human dopamine receptor subtypes bound to Rotigotine, revealing binding modes, activation mechanisms, and G-protein coupling specificity for drug design.

The paper chemically modifies host-derived tRNA fragments to selectively inhibit Fusobacterium nucleatum with nanomolar efficacy, while sparing other oral bacteria.

This study develops a potent non-covalent inhibitor of SARS-CoV-2 3CLpro, showing effective antiviral activity in human cells and animal models.

This study evaluates neutralization of Omicron sub-lineages by booster vaccination or BA.2 breakthrough infection sera using a pseudovirus panel.

The paper reports cryo-EM structures of FSHR in inactive and active states, revealing a conserved activation mechanism and the role of H6157.42 in agonist selectivity.

This study identifies Carmn, a SMC-specific lncRNA, as critical for maintaining GI smooth muscle contractile function and motility, with loss of function leading to impaired contractility and pseudo-obstruction.

This study shows that lumpy skin disease virus activates PERK and IRE1 pathways to support its replication, suggesting potential therapeutic targets for poxvirus infections.

The paper identifies novel CD4+ T cell populations associated with protective immunity by comparing single-cell transcriptomes of vaccinated mice challenged with a fungal pathogen.

This study evaluates how storage temperature, duration, and lyophilization affect the bioactivity and cargo retention of mesenchymal stromal cell extracellular vesicles.

This study develops a multiplex CRISPR-Cas system targeting ASF virus genomic loci, demonstrating resistance in gene-edited pigs and potential applications in agriculture and biomedicine.

This study develops a porous PCL capsule for long-term mAb release and shows that accelerated degradation can predict long-term release kinetics within 14 days.

The paper identifies ASPDH as a novel NAADP-binding protein through biochemical purification and ITC experiments, showing specific binding with a Kd of 455 nM, unlike previously identified NAADP-receptors.

This study identifies pyroptosis as the main cause of CD4 T cell loss in acute SIV infection in rhesus macaques, with IFI16 upregulation linked to viral loads and cell depletion.

This paper shows that teicoplanin inhibits SARS-CoV-2 cell entry by blocking cathepsin L proteolytic activity, effective against multiple variants with IC50 values of 2.038 M and 2.116 M.

The paper uses organoid models to show that WNT2B promotes vascularization in pregnancies, linking trophoblast function to vascular development in both intrauterine and ectopic pregnancies.

This study investigates the structural and biochemical features of Omicron BA.1 and BA.2 variants, showing increased infectivity and mouse ACE2 binding compared to wildtype, suggesting a potential human-cat-mouse-human transmission cycle.

The paper develops a pipeline to analyze grain quality traits in hybrid rice by identifying additive and dominant genetic loci, improving prediction accuracy for hybrid performance.

This study compares antibody neutralization efficacy against SARS-CoV-2 Omicron sub-lineages BA.1, BA.1.1, BA.2, and BA.3, showing increased resistance and the benefit of vaccine boosters.

This paper uses network mapping to identify plant genes and SNPs that influence microbial network architecture in Arabidopsis thaliana, revealing genetic control of microbial interactions and their impact on plant traits.

This study examines gene expression changes in Saccharibacteria TM7x and its host during symbiosis establishment, revealing dynamic interactions and functional roles in maintaining the relationship.

This study evaluates vaccine efficacy against SARS-CoV-2 Omicron in macaques, finding that both humoral and cellular immune responses are necessary for virologic control.

This study determines the crystal structure of the U2AF2 UHM-SF3B1 ULM interface and shows its role in pre-mRNA splicing and co-regulation with SF1.

This study reports the crystal structure of the Omicron SARS-CoV-2 RBD-ACE2 complex and identifies key mutations enhancing ACE2 binding and immune escape.

This paper analyzes the evolution of SARS-CoV-2 through multiple strain waves, showing increasing mutations and suggesting a feedback loop between viral population size and mutation accumulation leading to the Delta strain.

The paper identifies MEcPP as a plastidial retrograde signal that initiates a cascade leading to the biosynthesis of systemic stress response activators in response to biotic and abiotic stresses.

The paper examines the coevolution between rice landraces and their blast pathogen in China, finding that generalist pathogen lineages coexist with host genetic subdivision.

The paper shows that the retrograde signal MEcPP increases VIR3 abundance, reducing target enzymes and altering plastid metabolism and structure under stress.