X. He

This study compares foetal and adult human epicardium using single-cell RNA sequencing to identify regenerative programs and their absence in adults, suggesting ways to enhance cardiac regeneration.

The paper shows defective HIV-1 proviruses can be transcribed via intragenic elements, producing aberrant RNAs that may contribute to inflammation in HIV-positive individuals.

The paper examines how accurately plant and microbe communities predict each other and environmental factors across a glacier forefield successional gradient.

This study compares two mRNA SARS-CoV-2 vaccines in nonhuman primates, showing that CV2CoV, with optimized non-coding regions, provides better immune responses and protection than CVnCoV.

This study identifies ribosomal protein L23 as a driver of hepatocellular carcinoma metastasis by upregulating MMP9 expression and promoting tumor growth and metastasis in vivo.

The paper identifies A-to-I RNA editing in SARS-CoV-2 by analyzing RNA-seq data and shows it affects viral characteristics and evolution.

The paper compares community assembly processes between plant, soil microbiome, and leaf microbiome in a glacier forefield, finding differences in dispersal limitation, environmental response, and species specificity.

The paper analyzes SARS-CoV-2 mutation signatures to infer its natural host, finding similarities with bat coronaviruses and suggesting a shared host environment with RaTG13 and RshSTT182.

This study shows PLK2 loss predicts better response to PLK1 inhibitors in triple-negative breast cancer and suggests PLK2 as a biomarker for treatment response.

The paper presents cryo-EM structures of the ghrelin receptor bound to ghrelin and GHRP-6, revealing the binding pocket for the octanoyl group and providing insights for drug design.

This study identifies m5C mRNA modifications mediated by Plasmodium NSUN2 as critical for transcript stability and gametocyte development in malaria parasites.

This study shows that non-neutralizing antibodies targeting HIV-1 envelope regions reduce mucosal infection and virus burden in humanized mice through Fc-mediated effector functions.

The paper shows that in a glacier forefield, community assembly shifts from dispersal-dominated to niche-based processes after 60 years of succession, supported by declining multi-beta-diversity.

The paper presents cryo-EM structures of CCKAR with different G proteins to elucidate its G protein coupling promiscuity and ligand recognition mechanism.

This study investigates how EPAC1 regulates rickettsial adhesion to endothelial cells by modulating ANXA2 Y23 phosphorylation, using in vivo models and FluidFM.

The paper shows rapid but limited adaptation in copepod populations to combined ocean warming and acidification over 25 generations.

The paper determines the structure of the V2 vasopressin receptor bound to AVP and Gs, revealing how AVP activates the receptor and providing insights for drug design.

This study investigates the evolutionary mechanisms of sexual systems in liverworts, showing dioicy is ancestral and more stable than monoicy, driven by genetic and environmental factors.

This study shows that MMP12 knockout prevents weight and muscle loss in ApcMin/+ mice with cancer cachexia by disrupting insulin and glycolipid metabolism.

This study shows that low doses of Ad26.COV2.S vaccine protect rhesus macaques against SARS-CoV-2 challenge, with higher doses needed for upper respiratory tract protection.

The paper analyzes single-cell transcriptomes during liver transplantation to understand ischemia-reperfusion injury and identifies a protective role for TNIP3 in Kupffer cells.

This study designs a de novo regulation system using TFs and CREs to alter plant secondary metabolism, showing reduced tobacco alkaloids and nitrosamines in engineered plants.

The paper develops a non-infectious SARS-CoV-2 replicon system to study viral replication and test antiviral compounds, revealing cell-line-specific inhibitor potencies.

The paper develops a method to measure subnanometer position changes of biomolecules in live cell plasma membranes using extracellular quenchers and validates it by studying peptide-induced membrane perforation.

The paper identifies cis-regulatory changes in a gene linked to adaptive radiation in cichlid fishes by showing their impact on gene expression patterns across lineages.

The paper maps root-microbe interactions in Arabidopsis thaliana by identifying host genetic variants and microbial hubs that influence microbial network structures and functions.

This study uses a Drosophila larval model to show that ROS-dependent innate immune mechanisms control S. aureus MRSA virulence by modulating H2O2 production and antimicrobial peptide responses.

This study examines how smart glass affects stomatal sensitivity in Capsicum plants by altering light conditions, finding that light intensity is more critical than spectral quality for stomatal responses.

This study identifies TaGS1.1 as critical for nitrogen assimilation and spike development in wheat by analyzing CRISPR-edited mutants and their growth responses under varying nitrogen conditions.

The paper identifies microbial markers for early colorectal cancer detection across populations using meta-analysis and classifier models, achieving high diagnostic accuracy.