X. Li

This study identifies ethacridine, an FDA-approved antiseptic, as a potent inhibitor of SARS-CoV-2 by inactivating viral particles in cellular models.

This study shows HuR promotes NASH by enhancing DR5/caspase8/caspase3-mediated hepatocyte death through stabilizing DR5 mRNA.

This study identifies N4BP1 as an inhibitor of NF-κB activation by interacting with NEMO, and shows that caspase 8 cleavage inactivates N4BP1 during TRIF-dependent signaling.

This study shows that miRNA-223 inhibits gallstone formation in mice by targeting ABCG5 and ABCG8, key transporters in the bile cholesterol secretion pathway.

This paper identifies potent SARS-CoV-2 main protease inhibitors using accelerated free energy perturbation-based virtual screening of existing drugs, finding 15 inhibitors from 25 predicted drugs.

This study uses activity-based protein profiling to identify active enzymes causing polysorbate degradation in biotherapeutic production, finding more enzymes than traditional proteomics methods.

This paper reviews passive bionic grasper designs and develops a virtual prototype through an iterative design process and simulations to evaluate functionality and durability.

This paper introduces a simplified agarose microbead-based SiMPull method that is faster, easier, and more reproducible than the original technique while maintaining similar sensitivity and signal-to-noise ratio.

The paper identifies Hexosaminidase B as a residual host cell protein causing N-glycan degradation in a monoclonal antibody under stability conditions and develops strategies to mitigate its impact.

This paper introduces a hierarchical 3D-motion learning framework to map animal spontaneous behavior by capturing kinematics and learning dynamic behavior patterns.

This study shows that RANKL from bone marrow adipocytes regulates trabecular osteoclast formation and bone loss in mice, with implications for therapeutic targeting of bone marrow adiposity.

This study shows that H2-GMZ reduces cyst formation in ADPKD by inhibiting Cl- secretion, cell proliferation, and motility in both in vitro and in vivo models.

This study develops a model to characterize cell membrane mechanics using relaxation curves from optical tweezers, revealing insights into cell skeleton changes and protein diffusion.

The paper identifies azetidine derivatives that kill Mycobacterium tuberculosis without resistance by inhibiting mycolate assembly, showing a novel mode of action and favorable pharmacological profiles.

This study shows that real-time axonal fiber orientation during impact affects tract-oriented strain in white matter, increasing deformation magnitude and distribution.

This study analyzes HIV-1 env gene evolution in 12 perinatal transmission pairs, finding that most infections occur within two months of birth and fetal viruses show unique selection pressures.

This study identifies two new QTLs, Scon3 and Scon4, that influence sucrose intake in mice and act through a common postoral mechanism.

This study identifies miR-1 as a conserved microRNA in ticks that prolongs engorgement time and is differentially expressed across developmental stages.

This study identifies QTLs for sucrose consumption and neural responses in mice, finding new loci and confirming a known one involving the Tas1r3 gene.

This paper introduces pnGFP-Ultra, a fluorescent biosensor for detecting peroxynitrite in live cells with high selectivity and sensitivity.

Ilomastat improves mouse survival after irradiation by enhancing hematopoietic recovery through reduced inflammation and increased stem cell counts.

This study identifies NSP8 as a SARS-CoV-2 protein that suppresses MDA5-mediated antiviral immune responses by inhibiting type I IFN signaling.

The paper identifies a potent neutralizing nanobody against SARS-CoV-2 with high activity and stability for inhaled delivery.

This study compares the resistance of SARS-CoV-2 RNA terminated by Sofosbuvir and Remdesivir to exonuclease proofreading, finding Sofosbuvir-terminated RNA more resistant.

This study shows DDR1 signaling in pancreatic cancer cells promotes metastasis by inducing CXCL5 production, which recruits neutrophils to form extracellular traps that facilitate cancer cell invasion.

This study shows an inactivated SARS-CoV-2 vaccine induces neutralizing antibodies and CTL responses in rhesus macaques, effectively preventing viral replication and lung inflammation.

This study identifies two distinct CD4+ T cell subsets in the human liver, characterized by CD69 expression levels, with different functional profiles and microenvironmental requirements.

This study maps cisplatin-damaged gene loci and identifies key pathways and targets, revealing SPAG9 as a potential therapeutic target for testicular cancer.

This study uses 3D printing to create vessel architectures that induce more physiologically relevant phenotypes in vascular smooth muscle cells compared to 2D cultures.