X. Wang

A Mutation-driven oncofetal regression fuels phenotypic plasticity in colorectal cancer

This study identifies an oncofetal cell state that contributes to resistance in colorectal cancer and shows that targeting both this state and LGR5+ CSCs is needed for effective treatment.

KatG inactivation generates vulnerabilities in isoniazid resistant strains of Mycobacterium tuberculosis

The paper identifies vulnerabilities in isoniazid-resistant Mycobacterium tuberculosis strains by analyzing metabolic and transcriptional changes in katG mutants.

Trade-off between light deprivation and desiccation in intertidal seagrasses due to periodic tidal inundation and exposure: insights from a data-calibrated model

This study develops a data-calibrated model to predict intertidal seagrass growth by incorporating air exposure effects, revealing trade-offs between light deprivation and desiccation.

pan-MHC and cross-Species Prediction of T Cell Receptor-Antigen Binding

This paper develops pMTnet-omni, an AI system predicting TCR-pMHC binding across species and MHC classes, achieving high accuracy and showing clinical utility in predicting immune-related adverse events.

Increased multiplexity in optical tissue clearing-based 3D immunofluorescence microscopy of the tumor microenvironment by LED photobleaching

This paper introduces an LED photobleaching method to enhance 3D immunofluorescence microscopy multiplexity for tumor microenvironment analysis, achieving 8-plex imaging.

AKAP8 interacting with DDX5 to regulate R-loop balance involves in lung carcinoma cell growth

The paper identifies AKAP8's role in regulating R-loop balance through interaction with DDX5, promoting UCP2 transcription and lung carcinoma cell growth.

Virus-induced gene silencing (VIGS) as a tool for functional genetic analysis in passion fruit plants

This paper develops a VIGS vector in passion fruit to study gene function in biosynthesis of health-promoting compounds.

Aalbo1200: global genetic differentiation and variability of the mosquito Aedes albopictus

This study generates whole genome sequencing data from Aedes albopictus populations to analyze genetic differentiation and variability across tropical and temperate regions.

Development of an Engineered Mycobacterium tuberculosis Strain for a Safe and Effective Tuberculosis Human Challenge Model

This paper develops an engineered Mycobacterium tuberculosis strain with kill switches for a safe TB human challenge model, showing rapid clearance and low escape rates.

Omics-assisted systematic exploration of the intricate regulatory network of guvermectin biosynthesis centered by the cluster-situated regulator GvmR in Streptomyces

The paper identifies GvmR as a key regulator of guvermectin biosynthesis in Streptomyces, revealing its interactions with other regulators and pathways involved in precursor supply and energy synthesis.

Human microbiota is a reservoir of SARS-CoV-2 advantageous mutations

The paper identifies that the human microbiota contributes to SARS-CoV-2 mutations by replicating bacterial mRNAs with advantageous mutations, leading to chimeric RNAs and altered viral properties.

Human Papillomavirus 16 replication converts SAMHD1 into a homologous recombination factor and promotes its recruitment to replicating viral DNA

This paper shows HPV16 replication converts SAMHD1 into a homologous recombination factor by phosphorylation, enhancing its recruitment to viral DNA and reducing replication.

The mitochondrial deoxyguanosine kinase is required for female fertility in mice

This study shows that Dguok knockout causes female infertility in mice by impairing ovarian development, oocyte maturation, and mitochondrial function.

Activation of glucocorticoid receptor signaling inhibits KSHV-induced inflammation and tumorigenesis

This study shows that dexamethasone inhibits KSHV-induced inflammation and tumorigenesis by activating GR signaling, which suppresses IL-1 and induces IL-1Ra.

Proximity Labeling Expansion Microscopy (PL-ExM) resolves structure of the interactome

PL-ExM combines proximity labeling and expansion microscopy to visualize 3D interactome structures and assess PL technique performance.

Cellular COPI components promote geminivirus infections by facilitating the chloroplast localization of viral C4/AC4 proteins

This study identifies the COPI pathway's role in transporting geminiviral C4/AC4 proteins to chloroplasts, facilitating infection and suggesting COPI manipulation as an antiviral strategy.

Utility of T1 mapping and T2 mapping for non-invasive assessment of liver fibrosis: preclinical results

This study evaluates T1 and T2 mapping for assessing liver fibrosis in mice, finding they correlate with fibrosis stages and collagen/protein markers.

Polygonum Cillinerve polysaccharide inhibits Transmissible gastroenteritis virus by regulating microRNA-181

This study shows that Polygonum Cillinerve polysaccharide inhibits TGEV infection by modulating miRNA-181 and reducing apoptosis in PK15 cells.

Identification and functional analysis of eRNA markers for hepatocellular carcinoma based on high-throughput data

This study identifies three eRNA biomarkers for hepatocellular carcinoma (HCC) and shows their involvement in cancer progression, prognosis, and potential as therapeutic targets.

3D-printed, Citrate-based Bioresorbable Vascular Scaffolds for Coronary Artery Angioplasty

This paper develops a drug-eluting bioresorbable vascular scaffold with reduced strut thickness and controlled drug release, showing comparable pre-clinical performance to metallic stents.

Hepatocyte-Targeted siTAZ Therapy Lowers Liver Fibrosis in NASH Diet-Fed Chimeric Mice with Hepatocyte-Humanized Livers

Rationale design of unrestricted pRN1 derivatives and their application in construction of a dual plasmid vector system for Saccharolobus islandicus

The paper designs mutated pRN1 plasmid backbones to evade CRISPR immunity in Saccharolobus islandicus, enabling stable plasmid vectors and a dual plasmid system for genetic studies.

A force-sensitive adhesion GPCR is indispensable in normal equilibrioception

This study identifies LPHN2/ADGRL2 as a force-sensitive adhesion GPCR essential for normal equilibrioception by regulating mechanoelectrical transduction in utricular hair cells.

Chemo-senolytic therapeutic potential against angiosarcoma

This study explores combining cisplatin and the senolytic agent ABT-263 to treat angiosarcoma, showing that low-dose cisplatin induces senescence, which is then eliminated by ABT-263, reducing chemotherapy side effects.

Increased epithelial mTORC1 activity in chronic rhinosinusitis with nasal polyps

The paper identifies increased mTORC1 activity in CRSwNP epithelial cells and links it to cytokine production and inflammation in both CRSwNP and asthma.

Proteomic Analysis Reveals a PLK1-Dependent G2/M Degradation Program and Links PKA-AKAP2 to Cell Cycle Control

The paper uses proteomics and PLK1 inhibition to identify proteins degraded at G2/M, showing PLK1's role in coordinating proteolysis via SCF ligases and linking AKAP2 to cell cycle control.

Interplay of RAP2 GTPase and the cytoskeleton in Hippo pathway regulation

This study identifies RAP2 GTPase as a central integrator of cytoskeletal signals in Hippo pathway regulation, showing its role in mediating responses to cytoskeletal changes and its impact on Hippo kinase activity.

GABRD promotes the progression of breast cancer through CDK1-dependent cell cycle regulation

This study shows GABRD promotes breast cancer progression by regulating the cell cycle through CDK1 interaction.

Tricyclic and tetracyclic antidepressants upregulate VMAT2 activity and rescue disease-causing VMAT2 variants

Ongoing evolution of the Mycobacterium tuberculosis lactate dehydrogenase reveals the pleiotropic effects of bacterial adaption to host pressure

This study investigates the evolutionary adaptation of Mycobacterium tuberculosis lactate dehydrogenase (LldD2) under host pressure, showing its role in metabolic flexibility and virulence.