X. Yu

This study profiles the site-specific glycosylation patterns of ebolavirus GP using mass spectrometry, revealing complex N-, O-, and C-linked glycans that contribute to the glycan shield and restrict antibody neutralization.

The paper identifies the X chromosome of the Asian citrus psyllid and compares transcription and DNA methylation between male and female adults, finding sex-specific patterns and no direct link between methylation and gene expression.

This paper develops bright fluorophores and uses heavy water to improve fluorescence imaging of deep-buried hollow organs, achieving better visualization and diagnosis.

This paper introduces a method to discover rare rabbit monoclonal antibodies against small molecules using an indirect competitive screening approach, resulting in a highly stable antibody with exceptional halophilic properties.

This study compares the membrane-binding properties of Plasmodium vivax PLP1 and PLP2 with Toxoplasma gondii PLP1 using structural and functional analyses.

This study identifies how oncogenic RAS activates mTORC1 in multiple myeloma by co-opting amino acid sensing pathways through a novel signaling complex.

The paper shows that chromosome 1q amplification promotes melanoma metastasis by overexpressing ceRNAs that sequester tumor suppressor miRNAs.

This study identifies and characterizes quiescent stem cells in the mammalian esophageal epithelium using scRNA-seq and DNA methylation profiling in rat models.

This study shows that e-cigarette aerosol increases cardiovascular oxidative stress in mice with the ALDH2*2 genetic variant, leading to higher ROS, protein damage, and NF-kB activation.

This study shows lactate enhances CD8+ T cell stemness and improves anti-tumor immunity by increasing Tcf7 expression through histone acetylation.

The paper reveals TACAN is a homodimer with lipid-associated domains and suggests membrane lipids coordinate with the protein to sense mechanical signals.

This paper identifies macrocyclic peptides that inhibit KRAS signaling by binding to its hydrophobic pocket, showing on-target activity and improved proteolytic stability.

The paper examines S. commune fruiting bodies and hyphae to confirm the presence of calcium oxalate crystallites, demonstrating biomineralization in this fungus.

This study identifies a lineage of antibodies from infected rhesus macaques that neutralize 54% of HIV-1 strains by expanding the antibody-Env interface around the V2 loop.

This study identifies small molecule inhibitors of SARS-CoV-2 entry through high-throughput screening and validates Calpeptin as a potent inhibitor of SARS-CoV-2 and some variants.

This study compares the in vitro efficacy of four oxazolidinones against rapid-growing Mycobacteria isolates from Beijing, finding tedizolid most effective against M. abscessus and delpazolid against M. fortuitum.

This study identifies how NgR1 bridges reovirus capsid proteins to initiate infection, revealing a unique binding interface and its role in virus entry and receptor ligand interactions.

This study shows autophagosomes fuse with phagosomes to aid in the degradation of apoptotic cells in C. elegans, revealing a novel role for autophagosomes in phagosome maturation.

This study identifies m5C mRNA modifications mediated by Plasmodium NSUN2 as critical for transcript stability and gametocyte development in malaria parasites.

The paper investigates miR-384's role in regulating Reelin by inhibiting ADAMTS4 in neuronal cell lines, showing reduced ADAMTS4 and Reelin fragments with miR-384 overexpression.

This study identifies ACE2 as a marker of immuno-hot tumors in breast cancer by analyzing its expression and correlation with immune features across multiple datasets.

This study examines how combining straw returning with potassium fertilizer affects spring maize's lodging resistance, grain quality, and yield in Inner Mongolia.

The paper defines and extends the near-infrared biological window for improved in vivo fluorescence imaging, proposing new regions and demonstrating enhanced imaging capabilities.

This study investigates salt-induced structural transitions in the DNA-interacting protein SSB using magnetic tweezers and infrared spectroscopy, revealing discontinuous thermodynamic behavior at binding mode transitions.

The paper develops a PD-L1 and TLR7 dual-targeting nanobody-drug conjugate that synergistically activates innate and adaptive immune responses, showing potent antitumor effects in both 'hot' and 'cold' tumors.

This study shows that macrophage-derived cholesterol supports androgen biosynthesis in prostate cancer, contributing to resistance to therapy, and that targeting macrophages can enhance treatment outcomes.

This study identifies intrinsic cardiac adrenergic cells as contributors to septic cardiomyopathy by releasing norepinephrine that exacerbates cardiac dysfunction through β1-adrenergic receptor activation.

This study uses AIE dots for non-invasive NIR-IIb fluorescence hysterography to visualize uterine structures and function in mice without impairing reproductive capacity.

This study identifies and characterizes six AcMNPV-encoded miRNAs, showing they regulate both viral and host genes through suppression or enhancement of target expression.

The paper analyzes single-cell transcriptomes during liver transplantation to understand ischemia-reperfusion injury and identifies a protective role for TNIP3 in Kupffer cells.