X. Zhao

The paper uses a HOXA9-mCherry reporter and CRISPR/Cas9 screens to identify USF1/USF2 as regulators of HOXA9 in MLLr leukemia, showing their role in leukemia cell proliferation.

This study investigates abortion rates and risk factors in dairy cows and sheep in Ili, China, identifying Brucella melitensis as the main pathogen and highlighting management factors contributing to reproductive issues.

This study examines ACE2 receptor usage by SARS-CoV-2 across 14 mammalian species, finding broad receptor activity and implications for zoonotic transmission and animal models.

This study shows that chemotherapy, not tumor-draining lymph nodes, determines immunotherapy response in secondary tumors using mouse models.

This study identifies LY6E as a host protein that restricts entry of human coronaviruses, including SARS-CoV-2, through a mechanism distinct from IFITM3.

The paper investigates how lectin-like intestinal defensin HD5 inhibits 2019-nCoV Spike protein binding to ACE2, showing a high-affinity interaction and protective effect in vitro.

This study identifies the COMPASS-like complex in M. oryzae and shows it regulates H3K4me3-mediated gene expression critical for fungal development and pathogenesis.

This paper shows that HCFC1 and HCFC1R1 deficiencies block HSV-1 infection by inhibiting nuclear translocation of HCFC1 and VP16, offering potential new therapeutic targets.

This paper introduces a NIR-II cell tracker for real-time monitoring of stem cell behavior in vivo, revealing differential responses to diseased environments and enabling long-term tracking beyond 30 days.

The paper analyzes 120 SARS-CoV-2 genomes to identify genetic subgroups, recombination events, and a unique spike protein insertion that may enhance infectivity.

Sleep deprivation rapidly increases serotonin 2A receptor expression in the mouse frontal cortex through the immediate early gene Egr3.

This study shows that pharmacologic activation of pyruvate kinase (PK) enhances insulin secretion in preclinical diabetes models by stimulating the mitochondrial phosphoenolpyruvate (PEP) cycle.

This study shows plasmin cleaves ENaC channels at multiple sites, enhancing fluid clearance in lung injury models.

This study shows that fusion cytokines can induce tumor regression and systemic antitumor immunity in mouse models.

This study identifies a specific role for γ1-COP in neurite outgrowth during neuronal differentiation of mouse pluripotent cells, while showing functional redundancy between γ1-COP and γ2-COP.

This study creates a chimera of diphtheria toxin and TPP1 to enhance lysosomal enzyme delivery, showing improved uptake and efficacy in a mouse model.

This paper shows pyruvate kinase (PK) controls insulin secretion by regulating ATP/ADP ratios and mitochondrial metabolism in beta-cells, suggesting PK activation as a potential diabetes therapy.

The paper presents the cryo-EM structure of human ACAT1 and reveals its catalytic mechanism and substrate preference for unsaturated acyl chains.

The paper shows that H3K27me3, deposited by PRC2, is involved in cell differentiation in the unicellular diatom Phaeodactylum tricornutum.

This paper introduces a BLSTM network to separate overlapping bat calls, achieving high separation quality and species classification accuracy.

This study estimates the economic burden of severe mental disorder in China from 2014-2017 using prevalence-based methods, finding substantial direct and indirect costs.

The paper identifies MRISC cells as a novel intestinal stem cell niche that produces R-spondin1 via Map3k2 signaling to promote intestinal regeneration after damage.

The paper examines the 3D chromatin structure of mouse female germline stem cells during development, identifying changes in TADs and conserved compartments related to imprinted genes.

This study examines changes in IL-10 expression in myocardial infarction and its association with macrophage activation and cardiomyocyte apoptosis over time.

The paper introduces autoSTOMP, an automated protocol for spatially targeted optical micro proteomics, enabling efficient protein analysis of subcellular structures in human and mouse cells.

This study shows obesity accelerates pancreatic cancer by altering the tumor microenvironment, with reversible effects through weight loss.

This paper introduces AbMap, a high-throughput epitope mapping technology that identifies epitopes for over 200 antibodies in a single run, including 14 anti-PD-1 antibodies.

The paper reports a quadruple mutant of hepatitis B virus showing moderate resistance to tenofovir and demonstrates that combination therapy with entecavir and tenofovir effectively suppresses this resistant mutant.

This paper develops a deep learning scheme to classify M. marinum-infected and uninfected macrophages based on morphology, achieving high accuracy at early infection stages.