X. Zhao

The paper shows that morphogenesis in multi-layered tissues is self-organized by interfacial mechanical interactions that create compression gradients, leading to stratification or 2D morphogenesis depending on tissue fluidity.

This study shows SARS-CoV-2 entry into host cells relies on clathrin-mediated endocytosis and phosphoinositides, with ACE2's cytoplasmic domain and enzymatic activity not required for this process.

This study shows sulfur limitation increases duckweed starch yield without reducing growth, making it a promising method for biofuel production.

The paper presents the cryo-EM structure of the human Nav1.5-E1784K variant and identifies a mutational hotspot in fast inactivation segments linked to LQT3.

This study shows ARGONAUTE10 maintains miRNA gradients to regulate cell fate and division in Arabidopsis root meristems, preventing ectopic xylem formation.

This study identifies five new Asgard archaeal phyla, expands the Asgard superphylum, and supports a 2-domain tree of life by showing Tyrarchaeota as a deeper branching lineage than Heimdallarchaeota.

This study shows that SHARPIN is essential for platelet linear ubiquitination and function, particularly in responses to CRP and U46619, with impaired thrombosis in SHARPIN-deficient mice.

This study identifies PRMT1-mediated methylation of DUSP4 as a regulator of p38 MAPK activity, influencing megakaryocyte differentiation and thrombocytopenia in myelodysplastic syndromes.

This paper develops a barnacle-inspired hemostatic paste that rapidly seals tissues by repelling blood with a hydrophobic matrix and crosslinking with tissues under pressure.

This study shows that calorie restriction affects gut microbiome, which in turn influences metabolism, hormones, and brain function in obese individuals.

The paper examines how autophagy and mitochondrial fission impact the Harderian gland in male hamsters under different photoperiods, finding autophagy levels correlate with gland weight changes.

This study identifies the transferrin receptor (TfR) as an additional receptor for SARS-CoV-2 entry, showing that TfR-mediated infection can occur independently of ACE2 and that targeting TfR has anti-viral effects.

This study uses iTRAQ proteomics to identify 20E and PLC inhibitor-regulated proteins in Apolygus lucorum, revealing shared and distinct DEPs and their involvement in metabolic and signaling pathways.

This study shows that a western-style diet impairs gut microbiota's ability to clear bacterial pathogens, leading to chronic inflammation and insulin resistance.

This paper develops a regional difference-based evaluation method for ecosystem service value (ESV) in Gansu Province, China, showing increased ESV from 2000 to 2015 with forest and urban ecosystems contributing most.

The paper identifies species-specific genetic differences in ACE2 that determine SARS-CoV-2 entry capability and shows that humanizing these residues in koala and mouse ACE2 enables viral entry.

This study identifies TaGS1.1 as critical for nitrogen assimilation and spike development in wheat by analyzing CRISPR-edited mutants and their growth responses under varying nitrogen conditions.

This study investigates L-arabinose's antifeedant effects on cotton bollworm caterpillars, showing it deters feeding, suppresses gustatory responses, and inhibits sucrase activity.

This study identifies placental hormones associated with pregnancy complications by analyzing the secretome of mouse placental cells and linking findings to human pregnancy outcomes.

The paper constructs a tyrosine kinase protein interaction map, revealing EGFR network oncogenesis in 19% of EGFR wild-type lung cancers, which is targetable with EGFR inhibitors.

The paper identifies 8 putative cell wall synthesis genes in Betula pendula using RNA-seq data and constructs a gene co-expression network.

This study identifies the molecular mechanism by which CheY-P controls rotational switching of the bacterial flagellar motor in Borrelia burgdorferi by interacting with FliM and remodeling FliG2.

The paper shows that Par-3 and dynein mediate polarized endosome movement during asymmetric division, leading to Notch signaling asymmetry in daughter cells.

The paper identifies two SNPs in SARS-CoV-2 genomes prevalent in North America, traces their origin to Europe, and suggests they could be targets for surveillance and treatment.

This paper identifies and characterizes Fnr paralogs in Paenibacillus polymyxa WLY78, showing their roles in regulating nitrogen fixation and anaerobic metabolism through gene expression changes.

This study identifies redox and protein homeostasis as key factors in toxin-induced biliary atresia, showing that genetic modulation of these pathways affects cholangiocyte injury and suggesting potential therapeutic strategies.

This study expands the known diversity of magnetosome biogenesis in bacteria by analyzing new genomes and revealing an early evolutionary origin of magnetic nanoparticle formation.

This study identifies ACE2 orthologs from diverse species that can support SARS-CoV-2 entry, suggesting a broad host range for the virus.

This study shows that tumor-secreted extracellular vesicles suppress T-cell costimulation and that modifying these vesicles can enhance antitumor immune responses and improve immunotherapy effectiveness.

This study investigates how H-NS proteins evolved to sense environmental changes by comparing orthologs from different bacteria and using biophysical methods to reveal electrostatic interactions involved in adaptation.