Y. Cai

This study develops an IFN-armed RBD dimer vaccine that induces strong neutralizing antibodies and T cell responses, offering complete protection against SARS-CoV-2 in rhesus macaques with a single dose.

This study identifies ACE2 as a marker of immuno-hot tumors in breast cancer by analyzing its expression and correlation with immune features across multiple datasets.

This study reports cryo-EM structures of SARS-CoV-2 variants B.1.1.7 and B.1.351, revealing mutations that enhance infectivity and immune evasion.

The paper maps memory B cell receptors against SARS-CoV-2 spike variants, identifying 7 mAb competition groups and their epitopic regions, and shows their cross-reactivity and neutralization properties.

This study identifies SSR1 as a chaperone-like protein that enhances HSCA2-ISU1 interaction in the mitochondrial iron-sulfur cluster biosynthesis pathway, essential for plant mitochondrial function.

The paper compares glycosylation patterns of recombinant SARS-CoV-2 spike proteins across labs with infectious virus S protein, finding conserved site-specific glycan maturation stalling linked to protein structure.

The paper describes a modified fluorescence reduction neutralization assay for quantitatively assessing SARS-CoV-2 neutralizing antibodies in clinical samples, demonstrating its efficiency and accuracy.

The paper develops fluorescent probes to visualize SARM1 activation and identifies a nisoldipine derivative as a SARM1 inhibitor that protects axons from degeneration.

The paper determines the structure of the SARS-CoV-2 E protein-PALS1 complex using cryo-EM, revealing a hydrophobic interaction that explains viral spread and suggesting therapeutic targets.

This study isolates and characterizes bacteriophages active against invasive non-typhoidal Salmonella causing bloodstream infections in Malawi, identifying three phylogenetic clusters with varying host ranges.

This study identifies and characterizes AnHSD, a novel homoserine dehydrogenase from Arthrobacter nicotinovorans that exhibits high oxidation activity for L-homoserine, suggesting its role in bacterial catabolism.

This study creates a trimeric ACE2 variant with high affinity for SARS-CoV-2 spike protein and shows it inhibits viral infection in cell culture.

This study investigates the toxic effects of 1,4-dioxane in mice using histopathology and multi-omics approaches, finding DNA damage counterbalanced by repair mechanisms with no systemic metabolic impact.

This study shows that MFN1-mediated mitochondrial fusion enhances ATP production, which supports autophagy and macrophage mycobactericidal activity against Mtb.

This paper introduces a computational method for optical sectioning using phase-space imaging with an incoherent multiscale scattering model, achieving improved signal-to-background ratio in biological samples.

The paper reports cryo-EM structures of the SARS-CoV-2 spike protein with the D614G substitution, showing how the mutation affects trimer stability and infectivity.

This paper develops a prediction tool for atherosclerotic plaque progression using patient-specific multi-physical modeling and microenvironmental indicators to differentiate stable from unstable plaques.

This study shows that Mycobacterium tuberculosis relies on cytochrome bd oxidase to resist the adaptive immune response, particularly under acidic conditions in macrophages.

This study analyzes microbial settling strategies in a chemostat using adaptive dynamics to show how settling mechanisms and nutrient input affect evolutionary outcomes and population diversity.

The paper characterizes glycosylation of SARS-CoV-2 Spike and ACE2 using glycomics and simulations to understand their interactions and guide immunogen design.

The paper identifies PD-L1hi plasmablasts that suppress T cell responses during acute parasite infections.

The paper reports two cryo-EM structures of the SARS-CoV-2 spike protein, showing prefusion and postfusion conformations, and discusses their implications for viral entry and immune evasion.

This study develops a SARS-CoV-2 vaccine candidate using virus simulating particles that induces strong neutralizing immune responses with a single dose.

The paper identifies bHLH11 as a negative regulator of Fe homeostasis in Arabidopsis, showing it inhibits bHLH IVc transcription factors by recruiting TOPLESS/TOPLESS-RELATED corepressors.

This study shows that EYA and TIM regulate seasonal physiology in Drosophila by integrating photoperiod and temperature cues to control reproductive dormancy.

The paper investigates the genetic basis of rumen evolution by comparing transcriptomes and genomic data across ruminants, camels, and cetaceans, identifying key genetic innovations.

This study demonstrates that intracorneal delivery of HSV-1-targeting CRISPR/Cas9 mRNA prevents herpetic stromal keratitis in both animal models and human-derived corneas.

This study identifies differences in the oral microbiome between NPC patients and controls, highlighting a pair of co-excluding Granulicatella adiacens variants associated with cancer risk.

The paper shows that B cells avidly bind to the Plasmodium CSP repeat domain, suppressing responses to protective epitopes, and that truncated CSP molecules induce broader immune responses and better protection.

The paper develops reporter assays to study Ebola virus nucleoprotein (NP) function and finds that amino acid position 111 affects oligomerization, virion budding, and transcription/replication.