Y. Chen

The paper identifies a common neuroprotective response of microglia at retinal atrophy sites in mice and humans, mediated by galectin-3 and Trem2 interactions.

This study identifies NSD2 as a key driver of lineage plasticity and castration-resistance in neuroendocrine prostate cancer, showing its inhibition can restore sensitivity to AR inhibitors.

The paper shows genetically based adaptive differentiation in head size and shape between freshwater and marine sticklebacks, driven by limnetic feeding selection, but gill-raker traits show less conclusive genetic divergence.

This study shows that retinal bipolar cells use extracellular lactate as an alternative energy source via MCT2 transporters, maintaining ion and electrical homeostasis.

This paper introduces circDesign, an algorithm for designing synthetic circular RNA that improves stability and protein translation efficiency, demonstrated using rabies virus glycoprotein.

This study develops a resistance-resistant antimicrobial by inducing catastrophic DNA damage in intracellular mycobacteria through a hybrid organoruthenium-natural product that manipulates bacterial ROS production.

This study identifies a Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis that protects against intestinal inflammation by maintaining barrier integrity and preventing mortality from C. rodentium infection.

This study determines the crystal structures of A2AR with AB928 and 2-118, revealing distinct binding modes on A2AR and A2BR that explain AB928's dual-antagonistic properties.

This paper engineers a CD47 variant to protect T cells from macrophage clearance, enhancing antitumor efficacy by combining T cell and macrophage activation.

This paper develops a DNA-inspired conductive coating for neural microelectrodes, showing improved electrochemical performance and bio-integration compared to conventional materials.

This paper uses GPT-4 to extract data from synthetic biology papers, creating structured datasets that improve ML predictions for yeast fermentation.

This paper identifies the Rnf complex as essential for Fusobacterium nucleatum's metabolic adaptation and virulence, showing its role in amino acid catabolism, biofilm formation, and pathogenesis in a mouse model.

This study shows that deleting the Gclc gene in the endocrine pancreas of mice leads to severe diabetes due to oxidative stress and islet dysfunction.

This paper extends a 1D model of cell motility to 2D, showing that the interplay between mechanosensitive adhesions and membrane tension can lead to different motility modes like gliding and zigzagging.

This study compares the genetic architecture of skeletal armor traits in two stickleback species, finding more polygenic and heterogeneous variation in nine-spined sticklebacks.

This study identifies RAPSYN-mediated neddylation of BCR-ABL as a mechanism driving Ph+ leukemia progression and presents it as a therapeutic target.

This study shows Yarrowia lipolytica can metabolize cinnamic and p-coumaric acid to 4-hydroxybenzoic acid via multiple pathways involving a trans-cinnamate 4-monooxygenase.

This study investigates carbon catabolite repression in Pseudomonas putida M2 during simultaneous sugar and aromatic co-utilization, revealing simultaneous repression by sugars and aromatics and the role of crc and small RNAs.

The paper uses proteomics to compare DIPG cells in co-culture with brain organoids to control conditions, finding changes in adhesion, DNA synthesis, and dendrite growth pathways.

The paper identifies a stem-like proliferative state in prostate epithelial cells driven by ERG activation, which transitions to luminal cells and is associated with specific chromatin states.

This study shows that angiogenesis inhibitors enhance the effectiveness of metabolic therapies in gliomas by inducing anaplerotic nutrient stress.

This study shows that ZnF2-defective GATA3 mutations impair LLPS and DNA binding, reducing breast cancer progression and enhancing type I IFN signaling.

This study identifies MSMEG_0317 as essential for mycolic acid transport in Mycobacterium smegmatis, showing its role in maintaining the outer membrane structure.

This study investigates the formation of the sporoplasm membrane during microsporidia spore germination, revealing that the polaroplast transforms into the sporoplasm membrane via the polar tube.

This study identifies non-redundant roles of CLCa and CLCb in epithelial lumen formation through analysis of knockout mice and cell line models.

This study assesses genetic diversity in critically endangered Chieniodendron hainanense populations using GBS and SNP methods, finding limited diversity and weak genetic differentiation.

This study shows that the COP9 signalosome promotes neointimal hyperplasia via deneddylation and CSN5-mediated nuclear export of p27 in vascular smooth muscle cells.