Y. Chen

This study investigates the roles of two 14-3-3 proteins in Fusarium sacchari, showing redundancy and distinct functions in pathogenicity and development.

This study identifies E2F1 as a transcription factor regulating CCHCR1 expression through a bidirectional promoter with TCF19 during the G1/S cell cycle transition.

This paper introduces a deep learning framework for fast fluorescence lifetime imaging under low-light conditions, achieving robust results with few photons per pixel.

The paper identifies a novel MCR-1 variant with low β-lactam co-resistance and shows synthetic peptides from this variant have broad-spectrum antimicrobial activity.

This study shows that intestinal Surf4 deficiency reduces lipid absorption, secretion, and metabolism in mice, leading to weight loss and altered lipid levels.

This study engineered Yarrowia lipolytica to overproduce nervonic acid through metabolic pathway modifications, achieving high titers and purity.

The paper shows EGFR inhibition increases ALPP surface expression in lung adenocarcinoma, enhancing the effectiveness of ALPP-ADC therapy.

The paper shows that SNC1, an immune receptor, guards ADR1-L1 and ADR1-L2 from bacterial effector suppression, enabling plant immunity through sequence diversification and a layered defense system.

This study uses plastome data to analyze the genetic diversity and phylogeny of Cibotium species in China, identifying cryptic species and lineage differentiation to aid conservation and breeding efforts.

The paper identifies widespread stop codon readthrough events in plants and reveals the plasticity of stop codons in encoding amino acids.

This study identifies a C-terminal residue critical for SARS-CoV-2 spike protein trafficking and virion assembly, offering insights for vaccine design.

The paper identifies long-B prokaryotic Argonaute systems as cell suicide mechanisms that use effector proteins to eliminate invading nucleic acids through abortive infection.

This study characterizes a mouse model of ICF syndrome, revealing that Zbtb24 deficiency leads to hypogammaglobulinemia via enhanced CD19 activation and IL-5 signaling.

The paper shows that type-I conventional dendritic cells enhance checkpoint blockade immunotherapy effectiveness in pancreatic cancer when combined with pancreatitis.

This study shows that vaccinating macaques with a CD4bs-targeting immunogen elicits neutralizing bnAb precursors with structural features of CD4-mimicking antibodies.

This study shows that c-di-GMP interacts with putrescine via the YcgR receptor to regulate bacterial motility in Dickeya oryzea, with c-di-GMP inhibiting putrescine's effect.

This study uses E. coli outer membrane vesicles to deliver target proteins into eukaryotic cells with high efficiency and enables direct labeling of proteins within vesicles.

This paper identifies microbiome features distinguishing three patient clusters with abnormal glycometabolism, stratified using unsupervised clustering of clinical parameters.

This paper demonstrates that InsB-g7 CAR Tregs specific for an insulin B-chain peptide prevent autoimmune diabetes in NOD mice.

This paper introduces a method for rapid nanobody screening that preserves library diversity without subcloning or amplification bias, producing functional nanobodies against DR5 and Pfu DNA polymerase.

The paper redefines phytoplankton-associated bacterial taxa at the genus level using data from diatoms and dinoflagellates, identifying core genera and their ecological roles in the phycosphere.

This paper benchmarks viromics using Illumina, Nanopore, and PacBio sequencing technologies to assess their impact on viral community reconstruction and error rates.

This study shows that glutathione (GSH) is essential for lipid abundance in adult tissues, particularly in the liver, by repressing NRF2.

This study shows that preventing p53 acetylation improves coronary microvascular dysfunction and prevents heart failure in a mouse model of pressure overload.

This study identifies chloride ions as essential determinants of ferroptosis, showing that extracellular chloride levels influence lipid peroxidation and cell death.

This study assesses neutralization of SARS-CoV-2 Omicron subvariants by sera from different vaccination and breakthrough infection cohorts, finding that BQ.1.1 and XBB.1.5 show strong neutralization evasion.

This study shows that exosomes from BMSCs with miR-124-3p inhibitor reduce LPS-induced endometritis by modulating DUSP6, p-p65, and p-ERK.

The paper shows newly born mesenchymal cells migrate rapidly and are recruited to dermal condensates due to mechanosensitivity to tissue tension.

This study shows that peripheral macrophages contribute to CNS lesions in the Ndufs4(-/-) Leigh syndrome model, despite microglia depletion having limited effect.

This study investigates physical processes and environmental forces affecting single glioblastoma-related astrocyte cells and their aggregation into pre-tumor states.