Y. Chen

This study shows that SARS-CoV-2 N protein reduces Dicer, XPO5, SRSF3, and hnRNPA3, leading to pneumonia, and that inhibitors can reverse this effect.

This study traces the origin, divergence, and hybridization of three house mouse subspecies using population genomic data, revealing divergence times and patterns of introgression across Eurasia.

This study develops a bio-inspired hydrogel that promotes tendon-bone interface regeneration by activating Gli1+Dkk3+ progenitor cells, achieving 68% mechanical recovery.

This study produces diverse human milk oligosaccharides (HMOs) in transgenic plants, demonstrating their potential for cost-effective and sustainable large-scale production compared to microbial methods.

This study examines how mutations in polyphosphate metabolism affect biofilm, capsule formation, and virulence in hypervirulent Klebsiella pneumoniae using a model host.

This study evaluates the neutralization efficacy of a tetravalent vaccine booster against emerging SARS-CoV-2 variants, finding it induces higher neutralizing titers than breakthrough infection.

This study shows that Microsporidia infection impairs dendritic cell functions by targeting the p38/MAPK pathway via PP1, increasing susceptibility to secondary infections.

This study examines immune responses in CoronaVac-vaccinated individuals after Omicron infection, showing enhanced antibody and cellular immunity compared to unvaccinated controls.

The paper determines crystal and cryo-EM structures of PLCγ2 in autoinhibited states and bound to FGFR1 kinase domain, revealing dynamic inter-domain interactions in autoinhibition.

The paper identifies adeno-to-squamous transition (AST) as a mechanism of resistance to KRAS inhibitors in LKB1 mutant lung cancer and links KRT6A expression to poor patient outcomes.

This study identifies the CD36-PKM2-mtROS pathway as a mechanism by which oxidized LDL disrupts efferocytosis, contributing to atherosclerosis progression.

This paper identifies FOL-026, an osteopontin-derived peptide that binds neuropilin-1 and activates vascular cells, mimicking VEGF effects and showing potential for vascular repair.

This study shows that inhibiting KDM6B in myeloid cells improves response to PD1 blockade in glioblastoma by enhancing anti-tumor immunity.

This study defines the physiological role of wild-type PNPLA3 in maintaining hepatic VLDL-TG secretion and shows that the I148M variant impairs this function during lipogenic conditions.

The paper identifies a subpopulation of endothelial cells that resist detachment under fluid shear stress, improving the potential for vascular graft endothelialization.

The paper shows that Mtb's response to cholesterol, pH, and potassium is coordinated via the Mce3R regulator, with mce3R deletion reducing colonization in mice.

This study shows that SR-BI is necessary for efficient glucose uptake and metabolic homeostasis in adipocytes, as its absence leads to reduced glucose uptake and altered lipid metabolism.

This paper shows that fibronectin stimulates vascular smooth muscle cells to secrete collagen VI-rich extracellular vesicles that modulate cell adhesion and directionality by forming focal adhesions in the extracellular matrix.

The paper identifies a phage-encoded DNA methyltransferase as a trigger for the Ec86 retron system and describes its supramolecular assembly and defense mechanism.

The paper investigates the role of Prevotella copri in mediating the metabolic effects of a therapeutic food for malnutrition using gnotobiotic mouse models and multi-omics analyses.

The paper identifies chemotherapy-induced TXNIP as a negative regulator of GDF15 in CRC, showing its potential as a prognostic biomarker through organoid models.

This study shows PhoP directly regulates {gamma}-PGA synthesis in B. licheniformis and indirectly affects it through glutamate transport, nitrogen utilization, and ammonia assimilation.

This study reprograms hypoxia signaling by engineering PHD2 to enhance its catalytic efficiency, leading to reduced HIF-1 and hypoxia response transcripts under low oxygen conditions.

The paper identifies Methanolobus as dominant methylotrophic methanogens in Baltic Sea sediments and shows they use trimethylamine- and methanol-methyltransferases, not methyl-sulfide methyltransferases, to produce methane from DMS.

This paper presents optogenetic strategies to enhance phospholipid biosensors in live cells by reducing background signals and amplifying detection through light-controlled probe release and phase separation.

This study identifies conserved M protein peptides that elicit cross-neutralizing antibodies against multiple SARS-CoV-2 variants, including Omicron, when combined with RBD-specific antibodies.

This study uses an ovarian tumor-on-chip to investigate how extracellular matrix and shear stress influence tumor cell migration and phenotype, showing ECM's dominant role in migration modes and EMT transition.

This paper introduces a coevolution-driven method to simulate protein conformational changes, revealing ligand effects on the beta2AR receptor's activation and signaling pathways.