Y. Dong

This study shows that Celastrol reduces colitis by modulating gut microbiota, improving immune balance, and increasing metabolites like pyruvate and adenosine.

This paper identifies redox-related protein targets of peroxide antimalarials using chemoproteomics and confirms their impact on redox homeostasis in Plasmodium falciparum.

This paper reports the preclinical efficacy of ALD-R491, a vimentin-targeting compound, in treating COVID-19 by reducing viral entry, enhancing pathogen clearance, and suppressing overreactive immune responses.

This study shows that TOR kinase represses cytokinin catabolic enzyme translation, thereby regulating trans-zeatin levels and shoot development in Arabidopsis.

This paper develops a CRISPR/Cas13a system combined with super resolution imaging for direct, amplification-free viral RNA detection with improved sensitivity.

The natural lipid tripentadecanoin induces neuroglobin expression to protect against amyloid oligomer toxicity and retinal neurodegeneration in mammals.

This study shows that inhibiting AHR signaling enhances terminal differentiation of human erythrocytes by promoting F-actin remodeling and cytoskeleton maturation.

This study identifies AGL16's role in regulating gene expression and flowering time in Arabidopsis, showing partial dependency on SOC1 and involvement in water loss and seed dormancy.

The paper identifies AgMESH, a mosquito protein associated with melanin-based immunity, and shows its role in peritrophic matrix integrity and malaria parasite infection.

This paper develops a mini-replicon-based reverse-genetics system for RSV, enabling functional analysis of its genes and host interactions in Nicotiana benthamiana.

The paper shows TOR represses stress responses by maintaining H3K27me3 levels in Arabidopsis, affecting chromatin states and gene expression.

MIPSA identifies neutralizing IFNL3 autoantibodies in severe COVID-19 patients by profiling autoantibodies against DNA-barcoded proteins.

This study shows that colonic epithelial cells adapt to EGFR-independent growth, leading to chromosomal instability and accelerated by prior injury, without introducing cancer driver mutations.

The study shows that soil intake in mice increases gut microbial diversity and reduces serum IgE levels, suggesting potential prebiotic effects.

The paper uses cryo-EM and deep learning to analyze human 26S proteasome conformers, revealing dynamics of ubiquitin-mediated autoregulation during substrate degradation.

This study designs a de novo regulation system using TFs and CREs to alter plant secondary metabolism, showing reduced tobacco alkaloids and nitrosamines in engineered plants.

The paper develops a mathematical model to explain cross-species differences in myofibroblast effects on cardiomyocytes, identifying transient K+ currents as a key factor.

This study compares the therapeutic effects of Remdesivir and Au22Glutathione18 in COVID-19 golden hamsters, finding that the gold compound better suppresses viral replication and inflammation.

This paper validates a method to quantify aristolochic acid DNA adducts in human tissues and applies it to hepatocellular carcinoma samples, finding a low prevalence of adducts.

This study shows that deleting Nupr1 in HSCs activates quiescence, enhancing engraftment without affecting stemness or differentiation.

The paper identifies AMPK substrates and their roles in DNA damage response and histone acetylation through phosphoproteomics and histone modification analysis.

The paper identifies a long non-coding RNA, ASTILCS, critical for HCC cell survival and overexpressed in patient tumors.

This study investigates the biodegradation of polyester polyurethane by Aspergillus flavus G10 using multiple analytical techniques and identifies conditions that enhance degradation.

This study shows glyphosate inhibits melanin production in insects, reducing their survival after infection and increasing susceptibility to pathogens.

This study uses single-cell RNA-sequencing to identify a transitional cell state in peripheral neuroblastic tumors associated with poor prognosis and therapeutic targets.

This paper identifies a potent neutralizing antibody targeting the N-terminal domain of SARS-CoV-2 Spike protein, revealing it as a new therapeutic target.

The paper develops a portable qPCR platform for detecting Zika, dengue virus, and Wolbachia in Aedes aegypti mosquitoes, demonstrating its reliability and sensitivity for field use.

This study identifies HK2 as a marker for detecting underrepresented CTCs in NSCLC, revealing a distinct subpopulation with unique characteristics.

This study compares SARS-CoV-2 infection outcomes in three non-human primate species, finding that M. mulatta is most susceptible, followed by M. fascicularis and C. jacchus.