Y. Gu

The paper shows that a bacterial E1-E2 fusion protein, Cap2, primes cGAS for antiviral signaling through a process called cGASylation, which increases cGAMP production by ~50-fold.

This study identifies stemness-related genes in human CD34+ cells from different sources and culture conditions using scRNA-seq, revealing pathways involved in stemness maintenance and potential drug targets for HSC expansion.

The paper identifies chimallin as the primary protein forming the bacteriophage nuclear shell and characterizes its self-assembly into closed compartments.

SAIBR corrects autofluorescence in imaging data using a simple, platform-independent method, enabling accurate quantification of weakly expressed proteins across diverse systems.

The paper identifies CapW, a transcription factor that regulates CBASS gene expression in bacteria, showing it represses the system in uninfected cells and is activated by phage infection, though not required for anti-phage activity.

The paper uses single-cell transcriptomics to study cell fate transitions during early de novo shoot regeneration in Arabidopsis, identifying redifferentiation trajectories and regulatory factors.

This study identifies multiple SARS-CoV-2 receptors, including ASGR1 and KREMEN1, which enable virus entry and correlate with multi-organ tropism and clinical symptoms.

This study introduces scStereo-seq, a method for single-cell spatial transcriptome profiling in Arabidopsis leaves, revealing cell type-specific spatial gene expression gradients and developmental trajectories.

This study examines how Salmonella develops resistance to enrofloxacin under varying sub-inhibitory concentrations, identifying gene expression changes and mutations involved in resistance.

This study investigates how Toxoplasma gondii infection affects dopamine-sensitive behaviors and gene expression in mice, revealing interactions between infection and cocaine exposure that may contribute to neuropsychiatric disorders.

This study sequenced and analyzed 11 ocular trauma-sourced S. epidermidis genomes, identifying 10 potential biomarkers and revealing pathogenic strains may be independent of biofilm formation.

The paper shows that reduced endothelial miR-22-3p in NSCLC tissues promotes angiogenesis by inhibiting SIRT1 and FGFR1, leading to AKT/mTOR inactivation and tumor growth.

This study shows that time-restricted feeding near dawn alters long-term mouse behavior through SCN GABAergic neurons by affecting exosome-related genes and Kcc2.

This paper identifies mucoricin, a ricin-like toxin produced by Mucorales fungi, critical for mucormycosis pathogenesis and a potential therapeutic target.

This study characterizes the dynamic changes in B-cell receptor repertoires of COVID-19 patients using next-generation sequencing, revealing clonotype overlap, lineage expansion, and V gene usage patterns.

The paper identifies a bacterial endosymbiont in Rhizopus microsporus that enhances fungal virulence by suppressing amoeba predation and macrophage clearance.

This study identifies two efficient multiplex genome editing tools for Phalaenopsis orchids using a protoplast platform, with DPII-Cpf1 showing the highest editing efficiency.

This study identifies orf19.2500 as a mitochondrial protein essential for biofilm growth, virulence, and drug resistance in Candida albicans, with unique evolutionary inserts.

The paper examines how PD-L1 expression on tumor cells affects specific cell clusters in TCR-T cells through single-cell RNA sequencing and cytotoxicity assays.

The paper assesses how tumor PD-L1 levels impact TCR-T cell function and anti-PD-(L)1 efficacy using single-cell RNA sequencing and cellular assays.

This paper develops a lentiviral vector for β-thalassemia treatment that restores β-globin expression in Chinese patients with minimal tumorigenesis risk.

This study identifies human adventitial pericytes from saphenous vein as anti-calcific cells for prosthetic cardiac valve engineering, showing resistance to osteochondrogenic induction via miR-132 regulation.

This paper investigates adaptive immune activation in bone marrow of T2D patients and mice, showing that Abatacept reduces T cell activation and improves cardiac function.

This study uses CRISPR/Cas9 and assODN to create an isogenic cell model of the HBB -28 (A>G) mutation and analyzes its transcriptome effects, revealing altered gene expression and pathway activation.

This study shows that Nelfinavir inhibits DDI2, blocking NFE2L1 proteolysis and enhancing the effectiveness of proteasome inhibitors in cancer treatment.

This study isolates multiple SARS-CoV-2-neutralizing antibodies through site-directed screening, showing potent protection against virus infection.

This study shows Cyclin A can trigger mitosis through Greatwall or Cyclin B by regulating Cdk1 activity and phosphorylation of mitotic substrates.

This study identifies GRP78 and integrins as distinct host receptors for Rhizopus delemar invasion in nasal and alveolar epithelial cells, explaining differential mucormycosis susceptibility in DKA and hematologic malignancy patients.

This study identifies KMT2D as a tumor suppressor in pancreatic cancer, linking TGF-β signaling to the non-canonical activin A pathway through miR-147b and showing its role in cancer cell plasticity and metastasis.