Y. Wang

This study develops allogeneic gene-edited HIV-specific CAR-T cells secreting PD-1 blocking scFv, showing enhanced anti-HIV activity in vitro compared to autologous CAR-T cells.

This study identifies CARD9's protective role in neutrophils against colitis by maintaining mitochondrial function and cell survival, revealing a mechanism for intestinal inflammation control.

The paper isolates and identifies bacterial strains from deep-sea water and sediments in the Mariana Trench, finding that environmental factors shape culturable bacterial diversity.

This study investigates the dynamics of SpoVAEa protein movement and germinosome formation in B. cereus spores during germination, revealing heterogeneous behavior and persistence of protein complexes beyond germination initiation.

The paper identifies tuftsin as a natural human molecule that targets ACE2 and NRP1, impairing SARS-CoV-2 infection and suggesting its potential as a therapeutic for COVID-19.

This study identifies FAM84B amplification as a marker of poor prognosis in ESCC and shows it promotes cell proliferation by interacting with NPM1 to suppress CDKN2A.

This study investigates the structural basis of SARS-CoV-2 Omicron variant's immune evasion and transmissibility using cryo-EM, revealing conformational changes and enhanced ACE2 binding.

This study evaluates the effectiveness of a disinfectant combining highly complexed iodine and compound organic acids in inactivating African swine fever virus under various conditions, showing dose- and time-dependent inactivation with synergistic effects.

This study shows that Akkermansia muciniphila induces chronic extramedullary hematopoiesis through cooperation between IL-1R and TLR signals in a mouse model.

This study investigates how age-matching between fecal microbiota transplantation (FMT) donors and aged recipients affects microbiota establishment and resilience, finding that mismatched age may reduce resilience against inflammation.

This paper develops an engineered A549 cell model overexpressing ACE2 and TMPRSS2 to study SARS-CoV-2 infection and antiviral responses.

The paper identifies GauERF105 as a key gene involved in cotton resistance to Verticillium wilt through transcriptome analysis and functional validation.

The paper characterizes structural and functional changes in the SARS-CoV-2 Omicron variant's Spike protein, identifying new immune escape sites and providing insights for vaccine development.

This study shows that histone neutralization with STC3141 reduces circulating histones, improves oxygenation, and decreases lung edema in a rat model of LPS-induced ALI, similar to dexamethasone.

Antibodies from 3-dose vaccinated individuals neutralize Omicron and other variants, with some being ultrapotent and broadly reactive.

This study uses snRNA-seq and Stereo-seq to analyze the immunological microenvironment of cervical squamous cell carcinoma, identifying immune cell clusters and their associations with tumor progression and patient survival.

This study identifies TACAN as a PKD2 inhibitor that modulates its channel activity and mechano sensitivity in renal cells and zebrafish.

This paper develops a PBPK model to predict the biodistribution of magnetic nanoparticles under SMF and shows improved brain bioavailability with SMF and insulin conjugation.

The paper shows that chromogranin proteins undergo liquid-liquid phase separation at the TGN to recruit and sort proinsulin and other cargo molecules into secretory granules, independent of specific sequence elements.

This study compares immune responses between BioNTech and Sinovac vaccines in Hong Kong, finding Sinovac induces lower neutralizing antibodies and wanes faster against SARS-CoV-2 variants.

This study identifies THEMIS as a substrate of SHP1 and shows it has phosphorylation-dependent and -independent roles in T cell development.

This study identifies autophagy inhibitors as potential therapies for NF1 tumors by showing their effectiveness in Drosophila and human models.

The paper identifies an intermediate state during 2C-like-to-pluripotent state transition using a dual reporter system and finds key regulators involved in this process.

This study shows Pseudomonas aeruginosa uses quorum sensing to produce graded and bimodal responses to population density changes, without a clear threshold for gene expression activation.

This study investigates how DNA methylation in transposable elements disrupts the link between 3D chromatin organization and gene expression in rice after genome duplication.

This paper uses deep learning to segment 15 intracellular compartments from super-resolution images with one dye, achieving high accuracy and faster imaging.

This study investigates the effect of moxibustion on colorectal cancer liver metastasis using animal models, finding reduced metastasis rates and identifying potential molecular targets.

This study uses deep mutational scanning to show that charge balancing constrains antigenic evolution in H3N2 neuraminidase.

This study identifies how Omicron evades neutralizing antibodies by analyzing mutations and their effects on different epitope groups, showing over 85% of tested antibodies are escaped.

This paper engineers RNA viruses with an unnatural amino acid to create adjustable immune responses in mice, demonstrating potential for vaccine development.