Y. Wang

This study develops an organoid-based method to generate large quantities of NK cells from human pluripotent stem cells without feeder cells, achieving efficient and scalable iNK cell production.

The paper identifies a cellular pathway involving Importin alpha-4 and Virp1 that facilitates nuclear import of noncoding RNAs, including viroids and a subviral satellite RNA.

This study identifies tropifexor as a potent SARS-CoV-2 PLpro inhibitor through drug repurposing screening, showing antiviral activity in Calu-3 cells.

This study shows that Serum Amyloid A (SAA) worsens acetaminophen-induced liver injury by damaging sinusoidal endothelial cells and increasing platelet aggregation.

This study extracts and purifies β-2,7,11-cembratriene-4,6-diol from tobacco leaves and demonstrates its antiviral activity against TMV through in vivo and molecular assays.

This study identifies multiple SARS-CoV-2 receptors, including ASGR1 and KREMEN1, which enable virus entry and correlate with multi-organ tropism and clinical symptoms.

The paper analyzes 8,000 SARS-CoV-2 spike-targeting antibodies from 200 donors to identify common molecular features and demonstrates a deep learning model for predicting antigen specificity.

BCM3D 2.0 improves 3D bacterial cell segmentation in dense biofilms by using intermediate image representations generated by CNNs, enhancing accuracy even at low signal-to-background ratios.

This study shows that loss of endothelial PHD2 causes cardiac hypertrophy and fibrosis via HIF-2, and PHD2 is reduced in human cardiomyopathy.

This study shows host casein kinase 1 phosphorylates a viral phosphoprotein, altering its phase separation and affecting virus infection.

The paper shows that TMYX slows pacemaker cell rate by antagonizing cAMP-induced modulation of f-channels, similar to muscarinic stimulation or beta-blockers, but without affecting overall cAMP levels.

This study uses polymer simulations to model how the diploid human genome organizes relative to nuclear bodies, showing that co-phase separation explains genome compartmentalization and spatial arrangement.

The paper presents a cryo-EM structure of human NKCC1, revealing ion binding sites and mechanisms of ion coupling and specificity.

This study shows that mice with permanently farnesylated prelamin A live nearly normal lifespans but show aging-related defects, suggesting prelamin A accumulation contributes to aging phenotypes.

This study shows that EBV LMP1 activates mTORC1 and mTORC2 to promote cancer stem cell properties in nasopharyngeal carcinoma, with distinct roles in drug resistance, tumor initiation, and metastasis.

The paper identifies genomic features that determine the survival of HTLV-1 and HIV-1 clones in vivo, showing that radial chromatin organization, integration site, and host transcription influence clonal persistence.

This paper introduces 4DPhenoMVS, a low-cost 3D phenotyping pipeline for tomato plants using multiview images, showing high correlation with manual measurements and environmental impact on growth.

This study shows that humanized mice can be infected by SARS-CoV-2, leading to immune responses and immunopathology, providing a model for studying the virus and testing therapies.

The paper identifies JAK-STAT signaling as a key driver of lineage plasticity-driven resistance to AR targeted therapy in prostate cancer using integrated transcriptomic and scRNA-Seq analysis.

The paper examines how dominant species influence ecosystem stability across different spatial scales in Inner Mongolian grassland, finding that stability is linked to dominant species dynamics and precipitation patterns.

This study identifies a TM4SF1-positive cancer subpopulation in bladder cancer that drives intratumor heterogeneity and is associated with poor prognosis.

This study investigates how ACE2 and antibodies affect the conformational dynamics of the SARS-CoV-2 spike protein using smFRET and FCS, revealing that D614G modulates RBD energetics similar to ACE2 binding.

This paper introduces a novel COVID-19 vaccine based on a RBD-HR1/HR2 hexamer structure that induces high neutralizing antibody titers and alternative antibodies targeting the HR1 region in mice.

This study shows that upregulated PD-1 signaling in aged kidneys impairs podocyte health and that anti-PD-1 treatment improves podocyte aging and kidney function.

This study identifies Vaccinia E5 as a major inhibitor of the cGAS-STING pathway by promoting cGAS degradation through proteasome-dependent ubiquitination.

This study shows that Verbena officinalis extract reduces inflammation and enhances NK cell killing efficiency, with Verbenalin specifically improving viral infection response.

The paper investigates the role of parthenogenetic Asian longhorned ticks in spreading SFTSV, finding they contribute to rapid spread and long-range movement.

This study shows that endophilin's curvature-sensitive motif requires electrostatic guidance for synaptic vesicle recycling, and that altering this property can restore function in non-functional chimeras.