Y. Wang

The paper determines high-resolution structures of outer-arm dynein arrays bound to microtubule doublets, revealing a mechanism for motor coordination through ATP hydrolysis and tail-to-head interactions.

This study investigates how temperature affects electrophysiological properties of human atrial cardiomyocytes, revealing region-specific responses and proposing a hypothermia-based treatment for atrial fibrillation.

The paper establishes patient-derived orthotopic xenograft models and cell lines from pediatric high-grade glioma that replicate histopathology, molecular signatures, and drug response, providing a resource for research.

The paper identifies a mechanism by which H3K27me3 is recognized and transcriptionally repressed through the BAH-PHD-CPL2 complex in Arabidopsis.

The paper isolates antibodies that bind HLA-E-Leader peptide complexes and enhance NK cell cytotoxicity in both mice and humans.

This paper introduces TASEC, a method that enhances protein labeling and detection by using split enzyme complementation with orthogonal tags, demonstrating applications in cell enrichment and interaction studies.

This paper introduces a 3D self-rolled biosensor array for simultaneous electrophysiology and Ca2+ imaging in cortical spheroids, demonstrating its utility in drug screening.

This study shows that SR-A1 facilitates Leptospira phagocytosis by macrophages but also promotes bacterial dissemination and inflammation, worsening leptospirosis in mice.

This study identifies keratin 1-based epidermal green autofluorescence as a biomarker for non-invasive assessment of inflammation and oxidative stress levels in the body.

This paper develops a droplet-based microfluidics platform for high-throughput functional antibody screening, identifying potent cancer immunotherapeutics like CD40 agonists and anti-Her2/anti-CD3 bispecific antibodies.

This study identifies 24 FDA-approved compounds that inhibit SARS-CoV-2 replication, with five showing high safety indices and blocking S protein-mediated cell fusion.

This paper identifies and characterizes a potent human monoclonal antibody, HB27, that blocks SARS-CoV-2 receptor binding and membrane fusion, showing protective effects in mice and non-adverse effects in rhesus macaques.

This study shows that local brassinosteroid biosynthesis in the root elongation zone supports optimal root growth by creating a hormone concentration gradient that aligns with signaling maxima.

The paper introduces CQU-ConceFT, a standardized version of the ConceFT algorithm, to analyze non-stationary time series and visualize spindle structures in EEG signals.

This study identifies Xist-seeded nucleation sites that create local concentration gradients of silencing proteins, leading to X-chromosome inactivation through macromolecular crowding.

The paper identifies imprinted genes in flax endosperm and shows their role in intraspecific variation and domestication.

This study identifies a conserved ubiquitin- and ESCRT-dependent pathway for degrading lysosomal membrane proteins in human and yeast cells.

This study compares chronic and transient chromosomal instability in mice, showing that transient instability accelerates tumor formation through rapid clonal evolution.

This study shows that ARID1A loss causes DNA replication stress linked to R-loops and transcription-replication conflicts in human cells.

The paper uses DNA origami to pattern TRAIL-mimicking peptides at nanoscale distances, finding that 5 nm spacing induces death receptor clustering and apoptosis in breast cancer cells.

This paper demonstrates that hydrogel-coating enhances the in vivo stability of electrochemical aptamer-based biosensors without compromising detection performance.

This study identifies 36 upregulated genes across SARS-CoV-2-infected respiratory tract cells, highlighting inflammatory and interferon response pathways linked to cytokine storms in severe COVID-19.

This paper identifies rhodomyrtone as a broad-spectrum antiviral with activity against SARS-CoV-2 and other viruses, showing potent antiviral effects and low resistance potential.

This study shows that primary cilia on MC4R-expressing neurons are essential for MC4R's role in controlling food intake and body weight.

This study shows properdin oligomers adopt rigid extended conformations that are essential for their function in the complement cascade.

This study shows that SARS-CoV-2 ORF3a induces incomplete autophagy by interacting with UVRAG, impairing autophagosome maturation and enhancing viral replication.

This paper reports a monoclonal antibody, 3E8, that blocks multiple coronaviruses by targeting ACE2, showing broad-spectrum activity against SARS-CoV-2 variants and other coronaviruses.

This study uses mass spectrometry imaging to visualize cholesterol distribution in mouse brain tissue, showing reduced cholesterol in specific regions of NPC1 disease models and during development.

This study identifies LsAP2 as a transcription factor regulating seed shape in lettuce, showing its role in seed development and dispersal through interactions with LsBP and involvement in brassinosteroid pathways.

This study identifies DNA shape/mechanics as key determinants for nucleosome positioning by the INO80 chromatin remodeler in yeast.