Y. Wang

This study uses ribosome profiling to analyze SARS-CoV-2 and host mRNA translation in infected cells, finding that viral mRNAs are not more efficiently translated than host mRNAs and highlighting unique translational strategies.

The paper identifies cross-reactive CD8+ T cell receptors with high functional avidity to a SARS-CoV-2 epitope and its variants, showing their ability to activate and kill infected cells.

This study identifies four phylogenetic groups of Bdellovibrionota and their distribution in marine environments, revealing genomic traits associated with predation and adaptation to deep-sea conditions.

The paper analyzes RNA-seq data from three leaf tissues of Arabidopsis under various stress treatments to identify tissue-specific transcriptional responses and regulatory networks.

This study identifies aglycone polyether ionophores as broad-spectrum antivirals effective against multiple enveloped viruses, including SARS-CoV-2, and demonstrates their efficacy in curing JEV-infected mice.

This study shows that laccase genes are essential for root development and phenolic acid metabolism in Salvia miltiorrhiza using CRISPR/Cas9 gene knockout.

This study identifies N4BP1 as an inhibitor of NF-κB activation by interacting with NEMO, and shows that caspase 8 cleavage inactivates N4BP1 during TRIF-dependent signaling.

This study identifies a viral protein translation mechanism involving mitochondrial machinery and highlights mitochondria as a target for antiviral drug development.

This study shows that Shigella flexneri biofilm formation and virulence are influenced by pH, with acidic conditions promoting biofilm stability and virulence.

The paper identifies CDK4 as a regulator of cell size target size, distinct from growth-promoting pathways, and proposes a model linking mTORC1, p38, and CDK4 in cell size homeostasis.

This study quantifies extracellular electron transfer in planktonic bacteria using plasmonic nanocrystals, distinguishing between different cellular states and genotypes.

This study introduces a computational method to identify genetic regulators of cell identity using epigenetic data across diverse species and validates findings with CRISPR experiments.

This study shows that combining SHP2 inhibitors with KRASG12C inhibitors enhances efficacy in PDAC and NSCLC by overcoming resistance and remodeling the tumor microenvironment.

This study shows that MSR1 restricts Chikungunya virus infection by activating autophagy through interactions with ATG12 and the ATG5-ATG12-ATG16L1 complex.

This study identifies EGFR downregulation as a mechanism by which HPV infection improves prognosis in cervical and head and neck cancers, suggesting EGFR inhibitors could be potential anti-HPV therapies.

This study shows that inhibiting SHP2 in endothelial cells reduces tumor growth by damaging the tumor vasculature, independent of SHP2 effects in tumor cells.

This study investigates how MFG-E8 signaling contributes to age-related arterial damage, showing that its deficiency reduces elastolysis, fibrosis, and calcification in mice.

This study examines how short-term antifungal treatment affects gut microbiome diversity and composition in rats, finding significant bacterial changes but no major structural shifts in the microbiome.

The paper identifies ERG's role in prostate cancer by showing it inhibits basal cell differentiation through chromatin interactions, promoting luminal cell fate.

This study examines how pre-existing T cell characteristics influence the immune response to a yellow fever vaccine, finding that memory T cells and rare populations shape post-vaccination responses.

The paper shows that screening macrophages before analysis is crucial for accurate phenotype identification and that CAMP expression does not fit traditional M1/M2 classification.

This study identifies CDF-1 and SUR-7 as regulators of lipid metabolism in C. elegans, linking zinc homeostasis to lipid accumulation via the SREBP-SCD pathway.

This paper introduces FSEC-Nb, a method using nanobody technology to screen membrane protein expression without GFP fusion, successfully identifying ZAC orthologs and SARS-CoV-2 membrane proteins with high monodispersity.

The paper identifies horizontal gene transfer in bacterial strains affecting Drosophila host fitness through thiamine biosynthesis pathway variation.

This study reevaluates Spinach-based RNA visualization in plants, showing potential for ex vivo and in vivo RNA monitoring.

This study shows that reduced IF1 in obesity leads to mitochondrial reprogramming through ANT2 downregulation, improving insulin sensitivity despite increased body weight on a high-fat diet.

This study shows that inactivating ATPIF1 enhances CD8+ T cell antitumor activity by reprogramming their metabolism, leading to better tumor suppression in mouse models.

This study examines how mass-scaling and active plasticity influence trait responses to light and nutrient limitation in sunflower, showing both passive and active mechanisms contribute to resource acquisition.

This study identifies a metabolic pathway involving pyruvate decarboxylases that contributes to plant resistance against bacterial wilt disease, and shows how a bacterial effector inhibits this pathway to promote disease.

The paper identifies species-specific genetic differences in ACE2 that determine SARS-CoV-2 entry capability and shows that humanizing these residues in koala and mouse ACE2 enables viral entry.