Y. Wang

This study shows SARS-CoV-2 uses the SR-B1-mediated HDL uptake pathway alongside ACE2 for entry, and blocking this pathway inhibits infection.

This study identifies four FDA-approved drugs that inhibit SARS-CoV-2 infection in cell culture, with Maraviroc showing reduced S-protein mediated cell fusion.

This study identifies Bmp8a as a positive regulator of antiviral immunity, showing its role in enhancing type I IFN production and reducing viral load in zebrafish.

DEER-PREdict calculates EPR and NMR data from protein conformational ensembles to validate models and interpret experiments.

This study identifies PELP1/SRC-3-dependent regulation of metabolic kinases as a driver of therapy-resistant ER+ breast cancer and shows that targeting PFKFBs can block tumorsphere formation in resistant models.

This paper evaluates PTC299's ability to inhibit SARS-CoV-2 replication and reduce inflammatory cytokine production in tissue culture models.

This study examines the effects of different dietary protein levels on ewe growth, serum biochemistry, and lamb development during late pregnancy, finding no significant impact on growth performance but significant effects on metabolic indicators and lamb body measurements.

This study investigates how herbivory and pathogen infection affect salicylic acid (SA) signaling in citrus plants, showing that repeated herbivory reduces SA levels and defense responses over time.

This paper identifies two potent DHODH inhibitors with broad-spectrum antiviral activity against RNA viruses, including SARS-CoV-2, and suggests their potential clinical use.

This study performs a time-course transcriptome analysis of lettuce achenes to identify gene expression patterns and molecular mechanisms during achene development.

This study shows that CHMP5 regulates bone formation by controlling endolysosome-mitochondrion-mediated cell senescence, and targeting senescent cells can alleviate musculoskeletal abnormalities.

This study shows SARS-CoV-2 suppresses selenoprotein mRNA expression linked to ferroptosis, ER stress, and DNA synthesis, while increasing IL-6 expression in Vero cells.

The paper shows that susceptible Pi-ta alleles are retained due to their fitness benefit by acting as an off-switch for immune signaling.

The paper identifies a zinc metabolic defect in alveolar progenitor cells in IPF and aged mice, linked to impaired renewal and fibrosis through ZIP8 downregulation.

This study compares the gut DNA and RNA viromes of Chinese residents and Pakistani visitors, finding ethnic origin significantly influences virome composition and diversity.

This paper demonstrates a laser-induced cell sorting technique that isolates and cultivates single microbial cells with viability, achieving varying recovery rates across different species.

This study shows that obesity increases organ size, which correlates with higher cancer risk due to more cells at risk of becoming cancerous.

The paper shows that balancing selection maintains genetic diversity in hyper-divergent regions of C. elegans, enabling adaptation despite selfing.

This study conducts a meta-analysis of 12 articles to evaluate the protective effect of FMDV VP1 protein on animals, finding a significant protective effect with a combined effect value of -0.66.

This study uses coherent Raman microscopy to examine how shear and tensile forces affect fibrin molecular structure at different strain levels.

This study identifies fibroblast subpopulations in mouse and human lungs using scRNA-seq, revealing conserved transcriptomic signatures and their roles in fibrosis.

This study identifies multi-site oxidations and amino acid substitutions in urinary proteins as age-related features by comparing three age groups using mass spectrometry and statistical analysis.

This study investigates the pharmacokinetics and pharmacodynamics of inhaled phage PEV31 in mice, showing reduced MDR Pseudomonas aeruginosa burden.

This study shows the D614G SARS-CoV-2 spike protein variant is more infectious but has reduced ACE2 affinity and altered trimer conformation, affecting viral entry and antibody neutralization.

This study presents EM structures of the human mitochondrial calcium uniporter holocomplex with and without Ca2+, showing how Ca2+ affects its assembly and channel pore blockage.

The paper shows CYFIP2-containing WAVE complexes restrain RAC1 activation, affecting cell migration, and mutations in CYFIP2 can enhance its activity.

This study investigates whether ARG1 is expressed during human bone healing and finds it is not a reliable marker for regeneration.

This study identifies potent human neutralizing antibodies against SARS-CoV-2 from convalescent patients, with some showing high efficacy in blocking viral entry.

This paper performs population pharmacokinetics analysis of camrelizumab and finds no significant advantage of flat-dose or weight-based dosing regimens.

This study shows the SARS-CoV-2 envelope protein causes ARDS-like damage and identifies channel inhibitors as potential antiviral targets.