Y. Wang

This study investigates charge interactions in a charge-depleted protein using simulations and experiments, revealing context-dependent residue interactions and their impact on protein stability.

This study determines the structure of the full-length human growth hormone receptor using integrated SAXS, X-ray diffraction, NMR, and molecular dynamics simulations, revealing a flexible ensemble of domains.

The paper predicts the binding ability between SARS-CoV-2 spike protein and human ACE2, revealing adaptive mutations that enhance transmissibility in humans.

The paper uses molecular dynamics simulations to study phospholipid transport and specificity in a flippase, revealing a preference for phosphatidylserine and insights into substrate selectivity mechanisms.

This study investigates whether chloroquine and hydroxychloroquine inhibit 2019-nCoV infection by blocking ACE2 binding, showing both drugs suppress virus entry into ACE2-expressing cells.

This study measures antibiotic concentrations in sinonasal secretions, tissues, and serum after oral therapy in CRS patients, finding lower mucosal penetration and no significant clinical benefit except for slightly higher GSRS scores in the roxithromycin group.

This paper presents a chromosome-level genome assembly and annotation of Magnolia biondii, revealing insights into its evolutionary history and gene function.

This study shows that oral administration of a single nanobody provides broad protection against multiple ETEC strains by targeting conserved epitopes.

This study generates and tests human embryonic stem cell-derived immunity-and-matrix-regulatory cells (IMRCs) for treating lung injury and fibrosis in mice, showing efficacy and safety.

The paper investigates the ability of Arhopalus rusticus to transmit pine wood nematodes, finding that 12 beetles can transmit the nematodes through feeding on pine needles.

The paper determines how two mitochondrial chaperones bind different membrane proteins by analyzing their structural interactions and identifies factors that influence client specificity.

This paper introduces a method using DAPI staining to distinguish human and mouse cells in situ, showing distinct nuclear structures in mouse cells.

The paper determines the structure of SARS-CoV-2 Mpro and shows how GC376 inhibits its catalytic site, supporting its use as an antiviral drug.

This study reports the largest sequenced plant genome, Paris polyphylla var. yunnanensis, and identifies genes involved in polyphyllin biosynthesis.

This study shows that human limbal niche cells in 3D Matrigel can induce dedifferentiation of mature corneal epithelial cells into a progenitor state.

This study investigates whether reduced branched-chain amino acid (BCAA) levels after vertical sleeve gastrectomy (VSG) contribute to metabolic improvements in mice, finding that BCAA reduction is not necessary for weight loss or glucose tolerance.

The paper identifies DNase activity in invadosomes across cell types and species, revealing DNase X as the recruited enzyme that degrades extracellular DNA.

This study develops bent DNA bows to amplify and detect DNA interactions with salts and molecules, enabling sensitive and cost-effective analysis using gel electrophoresis and the modified Hill equation.

The paper identifies Vβ2-specific germline contacts that contribute to a focused T cell response against a parasite-derived peptide presented by H-2Ld, enhancing HIV control.

BCM3D improves segmentation and classification of bacterial cells in 3D biofilms using deep learning and mathematical analysis.

The paper identifies FZD7 as a marker of platinum-tolerant ovarian cancer cells that are susceptible to ferroptosis via the FZD7-β-catenin-Tp63-GPX4 pathway.

This paper introduces ScatNet, a deep-learning method for restoring 3D fluorescence microscopy images of turbid biological specimens, improving resolution and signal-to-noise ratio.

This paper develops CNN models to automatically classify Nugent scores from vaginal microscopy images, achieving higher accuracy than human experts.

This study identifies an IgA monoclonal antibody that blocks SARS-CoV-2 Spike-ACE2 interaction and provides mucosal immunity.

This study identifies 5mC regulators as prognostic markers in glioma using multi-omics analysis and develops a risk model to predict patient outcomes.

The paper uses single-cell RNA sequencing to show neuroendocrine prostate cancer cells originate from luminal-like cells, not basal cells, and identifies associated gene signatures.

This study shows that inhibiting mitochondrial respiration in RPE cells alters intracellular and extracellular metabolites, revealing a metabolic signature of mitochondrial dysfunction.

This paper introduces a DNA-based method to enhance multiplexed protein imaging using primary antibodies, demonstrating its application in cultured cells and mouse retina sections.

This study identifies YTHDF1 as a key regulator of intestinal immune responses against bacterial infection by modulating TRAF6 mRNA translation through m6A methylation.

This study shows ARID1A has opposite roles in promoting neural differentiation and suppressing cardiac differentiation from human pluripotent stem cells.