Y. Wu

The paper introduces six new near-infrared fluorochromes for spectral flow cytometry, enhancing the number of available fluorochromes for 3-laser systems.

The paper screens SARS-CoV-2 target cells across 11 animal species using single-cell transcriptomes, finding higher proportions in cats and detecting them in multiple pig cell types.

This paper shows that PCNA-123 increases the fidelity and activity of Dbh, a DNA polymerase prone to deletions, by promoting correct nucleotide incorporation and requiring a minimal DNA duplex length.

This study introduces a new bioprinting method using a yield-stress granular gel to position and assemble tissue spheroids in 3D for cartilage and bone tissue construction.

This study investigates the interaction between honey bees, the mite T. mercedesae, and DWV, showing that honey bee antimicrobial peptides suppress mite reproduction.

The paper quantifies cis-interactions in E-cadherin clusters using single-molecule FRET and simulations, showing both specific and nonspecific interactions contribute to lateral clustering.

This study shows that immunization with SARS-CoV-2 RBD induces antibodies that neutralize both SARS-CoV-2 and SARS-CoV without causing antibody-dependent enhancement.

This study expresses, purifies, and characterizes minimal type II PKS components from Ktedonobacter racemifer in E. coli, revealing self-malonylating activity of KrACP and no in vitro interaction between KrACP and KrKSCLF.

The paper identifies three microbial life strategies in soil that respond differently to snowmelt, influencing nitrogen availability during and after winter.

The paper identifies two SNPs in SARS-CoV-2 genomes prevalent in North America, traces their origin to Europe, and suggests they could be targets for surveillance and treatment.

This study identifies a protoporphyrin derivative that inhibits entry of enveloped viruses by targeting viral lipids, showing broad antiviral activity in vitro and in vivo.

This study identifies a polybasic domain in aPKC that mediates PM targeting and kinase activity through Par-6 interaction and allosteric regulation.

The paper shows PSGL-1 inhibits SARS-CoV and SARS-CoV-2 spike glycoprotein incorporation into pseudovirions, blocking virus attachment and infectivity.

This study shows that protoporphyrin IX and verteporfin inhibit SARS-CoV-2 infection in vitro and in a human ACE2-expressing mouse model by blocking ACE2-S protein interaction.

This study shows Carmofur inhibits SARS-CoV-2 main protease by covalently binding to Cys145 and occupying the S2 subsite, with an EC50 of 24.30 M in cell-based viral replication assays.

This study produces and tests an F(ab')2 fragment against SARS-CoV-2 RBD, showing potent in vitro neutralization with an EC50 of 0.07 g/ml.

The paper identifies an inverted Cav1 topology in exosomes secreted by prostate cancer cells, revealing a non-canonical autophagy pathway involved in disease progression.

This study identifies strong evolutionary convergence in the spike protein and ORF3a between COVID-19 and SARS-related coronaviruses, suggesting adaptive adaptation to the human ACE2 receptor.

This study expresses an Arabidopsis remorin protein in mammalian cells to form PD-like structures that transport macromolecules and resemble plant plasmodesmata in structure and function.

This paper constructs a multiscale model to compare the receptor binding kinetics of SARS-CoV-2 and SARS-CoV, showing slower association of SARS-CoV-2 with ACE2 and linking this to longer incubation periods and faster pandemic spread.

This paper develops an acoustogenetic method using focused ultrasound to control CAR T cells, enabling noninvasive activation to treat cancer with reduced off-tumor effects.

This study shows that the SARS-CoV-specific antibody CR3022 binds strongly to 2019-nCoV RBD with a KD of 6.3 nM, while other antibodies targeting the ACE2 site fail to bind, highlighting the importance of RBD differences for cross-reactivity.

This study shows that silicon enhances plant resistance against powdery mildew through distinct, multi-layered defense mechanisms involving PAD4-dependent and SA-independent pathways.

This study identifies arginine-vasopressin as a systemic regulator of glucagon secretion, showing its role in counter-regulatory responses to hypoglycemia and its impairment in type 1 diabetes.

This study identifies a novel G protein-biased and subtype-selective agonist for the 5-HT2C receptor from herbal extracts, showing efficacy in weight loss similar to lorcaserin.

The paper identifies a phosphorylation-regulated interaction between shugoshin and condensin at the centromere in budding yeast, essential for biorientation and chromosome segregation.

The paper reports the cryo-EM structure of the human TIM22 complex at 3.7 angstrom resolution, revealing its architecture and potential mechanism for protein import.

This study identifies how abnormal nitration and S-sulfhydration of the Sp1-CSE-H2S pathway contribute to the progression of hyperhomocysteinemia through a self-reinforcing cycle.