Y. Xu

This study introduces a metallo-supramolecular branched polymer to improve particle distribution in single-particle cryo-EM by preventing air-water interface damage and preferred orientation.

This study identifies TRIM21 as a regulator of PKR-mediated protein translation by modulating PP1 ubiquitination and eIF2 dephosphorylation, revealing its role in antiviral defense and potential therapeutic applications.

The paper develops an uncapped mRNA platform and demonstrates its effectiveness in inducing immune responses and protein expression in vitro and in vivo.

The paper shows that Arabidopsis HSC70.1 binds its own mRNA to inhibit translation, forming a feedback loop that regulates chaperone availability and enables non-cell-autonomous homeostasis.

The paper compares immunological characteristics of SARS-CoV-2 vaccine non-responders aged 18-59 and 60+ to identify factors associated with seroconversion and recommend booster vaccinations.

This study identifies FoxP3-mediated inhibition of RyR2 as a mechanism by which regulatory T cells suppress immune responses through reduced calcium signaling and impaired T cell-DC interactions.

This study uses scRNA-seq to create a single-cell atlas of murine reproductive tissues during infection-induced preterm labor, identifying gene expression signatures and intercellular communication changes.

This study compares genomes of orobanchaceous plants with different parasitic lifestyles to trace the evolutionary steps of plant parasitism.

This study identifies tissue-specific chromatin accessibility and gene expression in Papaver somniferum to uncover regulatory mechanisms for morphine and noscapine accumulation.

This study investigates the structural and biochemical features of Omicron BA.1 and BA.2 variants, showing increased infectivity and mouse ACE2 binding compared to wildtype, suggesting a potential human-cat-mouse-human transmission cycle.

This study compares T cell responses to common antigens in Parkinson's disease patients and healthy controls, finding no significant differences in antigen-specific T cell activation or cytokine production.

This study identifies CIS as a regulator of GM-CSF signaling that controls macrophage polarization via the STAT5-IRF8 axis, influencing immune responses and allergic inflammation.

This study shows that PPAR-γ activation with rosiglitazone reduces oxidative stress and promotes xenograft regeneration in a dental follicle cell model.

The paper identifies PD-specific gene signatures in peripheral memory T cells by analyzing RNA-seq data from PD patients and healthy controls.

This study shows that neutrophil extracellular traps (NETs) disrupt airway epithelial barrier function by causing cell death and E-cadherin degradation, which can be mitigated by alpha-1 antitrypsin.

This study improves plant growth-promotion by engineering specialized bacterial mutants within a single species and assembling them into consortia that enhance root colonization and disease resistance.

This study identifies a chromosomal locus in Streptococcus gallolyticus subspecies gallolyticus that is critical for its pathogenicity in colorectal cancer.

This study shows Streptococcus gallolyticus subsp. gallolyticus upregulates collagen expression in CRC cells, which mediates its ability to promote cell proliferation and tumor growth.

This paper introduces a synthetic carbon fixation cycle in plants that fixes CO2 without RuBisCO, showing increased photosynthetic capacity in transgenic Camelina sativa.

This study investigates how bacteria grow in 3D hydrogels and finds that their growth depends on disturbance frequency and hydrogel density, explained through stochastic resonance theory.

The paper identifies three TME cell subtypes in colorectal cancer and their associated immune escape mechanisms using transcriptomic data from public datasets.

This paper identifies a novel intergeneric recombinant geminivirus as the cause of soybean stay-green disease, showing it induces symptoms and can be detected in seed coats but not seeds.

The paper uses a microfluidic platform to study paracrine interactions between human microvasculature and fibroblasts, identifying growth factors and cytokines that enhance vasculature growth.

The paper identifies GauERF105 as a key gene involved in cotton resistance to Verticillium wilt through transcriptome analysis and functional validation.

This study shows that Serum Amyloid A (SAA) worsens acetaminophen-induced liver injury by damaging sinusoidal endothelial cells and increasing platelet aggregation.

The paper creates a single-cell atlas of colorectal pre-cancerous polyps, identifying distinct molecular programs in adenomas and sessile serrated lesions and their associations with CRC subtypes.

The paper shows that FoSir5 decrotonylates key targets to regulate metabolic state switching during conidial germination in Fusarium oxysporum.

This study identifies 322 viruses in 34 grasshopper species, including 202 novel species, and finds phylogenetic congruence between grasshoppers and certain viral families.

The paper identifies JAK-STAT signaling as a key driver of lineage plasticity-driven resistance to AR targeted therapy in prostate cancer using integrated transcriptomic and scRNA-Seq analysis.