Y. Xu

This paper reports the preclinical efficacy of ALD-R491, a vimentin-targeting compound, in treating COVID-19 by reducing viral entry, enhancing pathogen clearance, and suppressing overreactive immune responses.

This study identifies endothelial MEKK3 as a regulator of inward arterial remodeling through TGFβ-Smad2/3 signaling, leading to hypertension and atherosclerosis.

This study sequenced and analyzed 11 ocular trauma-sourced S. epidermidis genomes, identifying 10 potential biomarkers and revealing pathogenic strains may be independent of biofilm formation.

This study shows that disrupting rRNA biogenesis in mouse embryonic stem cells induces a 2C-like state through reorganization of peri-nucleolar heterochromatin and activation of the 2C program.

This study induces human adipose-derived mesenchymal stem cells into hepatocyte-like cells using small-molecule cocktails and growth factors, producing cells with mature phenotype and function.

This study identifies two distinct roles of CSP in protein quality control, showing that dysfunction leads to lipofuscin accumulation and neurodegeneration in a Drosophila model.

The paper determines the structure of infective Getah virus at 2.8 Å resolution using cryo-EM, revealing glycosylation, S-acylation sites, and lipid interactions critical for immune evasion and host cell invasion.

This study shows PFNA exposure impairs mouse oocyte maturation by causing spindle defects, mitochondrial dysfunction, oxidative stress, DNA damage, and apoptosis.

The paper isolates and characterizes a Cyprinid herpesvirus strain YZ01 from goldfish exposed to elevated water temperatures, showing high genomic similarity to other C genotype strains.

This paper identifies Rad52's role in facilitating class-switch DNA recombination to IgD through microhomology-mediated alternative end joining, involving Zfp318 modulation and phosphorylation.

This study demonstrates that stem cell-derived secretome reduces intraocular pressure and protects retinal ganglion cells in glaucoma models through COX2-PGE2 pathway activation and extracellular matrix remodeling.

This study identifies p17 as a viral protein that inhibits the cGAS-STING pathway by interacting with STING and disrupting TBK1 and IKKε recruitment.

This study uses molecular dynamics simulations to reveal atomic-scale diffusion dynamics of the WRKY transcription factor along DNA, including base-pair stepping and strand preference.

This study evaluates fitness costs of CRISPR/Cas9 in Drosophila by tracking allele frequencies of transgenic constructs, finding moderate off-target costs but no direct Cas9 costs, with Cas9HF1 minimizing off-target effects.

This study shows that endothelial Unc5B maintains blood-brain barrier integrity via Wnt/{beta}-catenin signaling, with potential therapeutic applications for CNS diseases.

This study identifies mutations in wzc and wcaJ genes in hypervirulent Klebsiella pneumoniae that confer phage resistance but reduce virulence.

The paper uses Hi-C data to show that changes in chromatin compartmentalization classify prostate cancer progression, with specific gene clusters switching compartments and contributing to disease progression.

This study shows that SLIT2-ROBO signaling in tumor-associated microglia/macrophages promotes glioblastoma immunosuppression and vascular dysmorphia, and its inhibition reduces tumor growth and enhances therapy.

The paper uses mass spectrometry to analyze proline hydroxylation in collagens, finding heterogeneity in hydroxylation patterns across different collagen types and sources.

This study identifies novel SARS-CoV-2 receptors through a CRISPR activation screen, revealing LDLRAD3, TMEM30A, and CLEC4G as functional receptors independent of ACE2.

This paper develops a mini-replicon-based reverse-genetics system for RSV, enabling functional analysis of its genes and host interactions in Nicotiana benthamiana.

This paper shows that lipoylated H-protein can catalyze glycine cleavage and synthesis reactions in vitro without the other GCS proteins.

The paper investigates how RNA-binding proteins (RBPs) influence RNA polymerase II activity through phase separation, showing that RBPs like PSPC1 enhance polymerase engagement and transcription.

This paper develops a circular RNA vaccine encoding SARS-CoV-2 Spike RBD, showing broad protection against multiple variants including Delta and Omicron.

This paper addresses the embeddability problem in transition rate estimation by proposing eight methods, including a novel approach, tested on a one-dimensional toy model.

This study compares the metabolic profiles of sweet potato leaves grown in soil versus hydroponic systems to identify metabolites associated with taste quality differences.

This study identifies age and ethnicity-specific gene expression biomarkers for immune aging using transcriptomic data from peripheral blood mononuclear cells.

This study shows that time-restricted feeding near dawn alters long-term mouse behavior through SCN GABAergic neurons by affecting exosome-related genes and Kcc2.

This study shows that stimulating soluble guanylate cyclase (sGC) with BAY41-8543 reduces skeletal and cardiac muscle dysfunction in mdx mice, suggesting sGC as a therapeutic target for Duchenne muscular dystrophy.