Y. Zhou

The paper generates and indexes an EMS mutant library for KN9204 wheat to enhance functional genomics and genetic manipulation for agronomic traits.

This study uses mid-infrared spectra of milk to establish models for assessing mammalian evolutionary relationships and genetic distances with high accuracy.

This paper identifies and engineers a high-fidelity Cas12i variant with broad PAM recognition and minimal off-target activity for improved genome editing.

This study identifies molecular mechanisms of Zika virus-induced oncolysis in neuroblastoma and highlights a promising oncolytic virotherapy candidate.

This paper conducts a bibliometric analysis of immunotherapy research in pancreatic cancer, identifying key trends, hotspots, and future directions.

This study shows that AHR activation by dietary ligands improves gut barrier function via zinc-dependent pathways, highlighting the role of zinc in AHR signaling and its protective effects against IBD.

The paper reports cryo-EM structures of PTH1R bound to PTH and PTHrP, revealing molecular mechanisms of hormone recognition and selectivity.

The paper optimizes CRISPR interference screens in human iPSCs using dCas9-KRAB-MeCP2, identifies ARID1A-dependent growth regulators, and finds proteasome-related genes as synthetic lethal targets.

This study investigates how defects in specific antennal segments of Aedes albopictus affect blood-feeding behavior by analyzing the role of flagellomeres in host detection.

This paper introduces a particle detection framework for cryo-electron tomograms that improves detection accuracy with minimal labeling and faster training.

This study uses cryo-electron tomography to reveal the high-resolution 3D structure of 293T cell membranes, showing lipid bilayer thickness and protein distribution.

This study develops a chimeric vesiculovirus (VMG) expressing MorV glycoprotein, showing anti-tumor effects in sarcoma models with in vitro efficacy and in vivo tumor reduction.

This paper determines structures of HIV-1 antibodies at different stages of maturation to understand how neutralization breadth develops through affinity optimization.

This study identifies mitochondrial Ca+2 dysregulation via MAM-STAT3 as a driver of immunosenescence in type A mandibuloacral dysplasia.

This study examines how systemic hypoxia alters fuel metabolism across organs, revealing distinct metabolic adaptations in acute versus chronic hypoxia.

The paper identifies HLY72, a small-molecule derivative of lycorine, as an anti-obesity agent that targets Na+/K+-ATPase α3 in the brain, promoting lipolysis and thermogenesis without affecting food intake.

The paper reports cryoEM structures of TCR-CD3 complexes and pMHC ligands, revealing structural insights into TCR recognition of cancer antigens.

The paper resolves four conformations of the AdiC transporter and quantifies their probabilities using polarization-microscopy, showing comparable KD values to prior methods.

The paper uses polarization microscopy to determine the conformational dynamics of AdiC transporter molecules and builds a 4D model of its transport mechanism.

This paper describes a method to generate human atrial-like cardiomyocytes from induced pluripotent stem cells that respond to adrenoceptor agonists.

The paper presents a near-atomic structure of the NuA4 complex and shows it has auto-inhibited conformation that becomes active upon substrate and co-factor binding.

The paper determines cryo-EM structures of gp130 family cytokine signaling complexes to reveal structural insights into their assembly and biological specificity.

This study investigates giant panda reproductive physiology, finding that pregnancy lasts 42 days and involves a triphasic progesterone profile with CL reactivation postponed to shorten the active luteal phase.

This study shows that the T60 variant of CARD8 inhibits NLRP1 inflammasome activation by interacting with NLRP1 and preventing inflammasome assembly.

This study shows that mutations in the SARS-CoV-2 nucleocapsid protein enhance viral replication and pathogenesis by increasing phosphorylation and resisting kinase inhibition.

This study develops a multiplex CRISPR-Cas system targeting ASF virus genomic loci, demonstrating resistance in gene-edited pigs and potential applications in agriculture and biomedicine.

This study identifies nirmatrelvir-resistant SARS-CoV-2 variants with high in vitro fitness and shows that remdesivir remains effective against them.

This study shows that reducing CTPS in the fat body of Drosophila alleviates HFD-induced obesity by decreasing lipid storage and TAG levels.

The paper shows that Arabidopsis HSC70.1 binds its own mRNA to inhibit translation, forming a feedback loop that regulates chaperone availability and enables non-cell-autonomous homeostasis.