Z. Liu

The paper identifies a catch bond mechanism in a bacterial adhesion complex that resists high shear forces in the human gut.

This paper develops dual orthosteric-allosteric inhibitors of PfHT1 that selectively target malaria parasites over human cells, showing potent activity against multidrug-resistant strains.

This study shows that deuteration of small-molecule fluorophores enhances their brightness, chromostability, and photostability in cellular imaging.

The paper shows that KDM3A and KDM3B, along with OCT4/SOX2, regulate H3K9 methylation to maintain pluripotency in porcine-induced pluripotent stem cells.

This study identifies Bmp8a as a positive regulator of antiviral immunity, showing its role in enhancing type I IFN production and reducing viral load in zebrafish.

This study shows SARS-CoV-2 suppresses selenoprotein mRNA expression linked to ferroptosis, ER stress, and DNA synthesis, while increasing IL-6 expression in Vero cells.

This study shows that high levels of circulating mitochondrial DNA predict severe illness and mortality in COVID-19 patients.

This study identifies lineage-specific transcription factors and super-enhancers driving neuroblastoma self-renewal and differentiation using ATRA treatment and CRISPR screening.

The paper identifies GRL0617 as a non-covalent inhibitor of SARS-CoV-2 PLpro with an IC50 of 2.1 μM, supported by co-crystal and NMR data showing its mechanism of action.

This study uses quantitative proteomics to show ESD reduces inflammation and modulates immune response in OA, protecting joints and cartilage.

This paper describes a catalase-based therapeutic for COVID-19 that reduces oxidative stress and cytokine production in human and animal models without toxicity.

This paper develops a numerical model to simulate bleb formation and evolution in cells, showing how parameters affect bleb size and shape.

This study shows SMAD6 is essential for endothelial cell alignment under laminar shear flow, downstream of Notch1, and its loss disrupts barrier function and gene expression.

This study shows that excessive polyamine production in keratinocytes drives self-RNA sensing by dendritic cells, contributing to psoriasis inflammation.

This study identifies SF3B1 mutations causing anemia in MDS by inducing missplicing of MAP3K7, leading to reduced p38 MAPK activity and disrupted erythroid differentiation.

The paper analyzes antibody repertoires against endemic human coronaviruses in children and adults, finding distinct epitope targets and cross-reactivity patterns.

The paper screens SARS-CoV-2 target cells across 11 animal species using single-cell transcriptomes, finding higher proportions in cats and detecting them in multiple pig cell types.

This study identifies MYB10 allelic variation as the primary driver of natural color variation in strawberry fruit, with specific mutations affecting anthocyanin biosynthesis in both diploid and octoploid species.

This paper develops CNN models to automatically classify Nugent scores from vaginal microscopy images, achieving higher accuracy than human experts.

This study develops two neutralization assays for SARS-CoV-2 using VSV and a clinical isolate, showing high concordance between monoclonal, polyclonal antibodies, and ACE2-Fc in neutralizing activity.

This study identifies 5mC regulators as prognostic markers in glioma using multi-omics analysis and develops a risk model to predict patient outcomes.

The paper analyzes virus infections in non-human primates, identifies high-risk species for cross-species transmission, and suggests measures to prevent viral spread between humans and primates.

The paper identifies NRF2-CEBPB cooperativity in promoting tumor-initiating activity in NRF2-activated NSCLCs through enhancer remodeling and the NRF2-NOTCH3 regulatory axis.

This study shows SARS-CoV-2 infects human intestinal enterocytes via TMPRSS2 and TMPRSS4, but viral particles in stool are inactivated, suggesting limited fecal-oral transmission.

The paper shows that PIKfyve kinase inhibitors block infection by Zaire ebolavirus and SARS-CoV-2 by preventing viral content release.

This study systematically analyzes ferroptosis in cancer using TCGA data, finding that ferroptosis-related genes are aberrantly expressed and that FPI is associated with prognosis and drug sensitivity.

The paper determines the cryo-EM structure of phosphorylated α-synuclein fibrils at Tyr39, revealing structural changes linked to Parkinson's disease pathology.

PM2RA detects and quantifies microbial relationship alterations between healthy and diseased states, showing higher specificity and sensitivity than co-occurrence-based methods.

This study identifies SARS-CoV-2 host targets and perturbed proteins in PBMCs from COVID-19 patients, revealing potential virulence factors involved in cytokine storms and disease pathogenesis.