Z. Sun

KaryoCreate generates chromosome-specific aneuploidy by targeting centromeres with CRISPR, showing it can induce gains or losses of targeted chromosomes in human cells.

This study shows that treatment history influences the evolution of carbapenem resistance in Klebsiella by shaping the genetic loci involved and their fitness costs.

This study shows low light stress reduces summer maize yield by decreasing leaf photosynthetic rate, impairing sucrose transport to grains, and creating a sugar concentration gradient that inhibits sucrose output.

The paper identifies genetic and regulatory mechanisms underlying heterosis in the rice hybrid Y900 by analyzing genome and transcriptome data from its parental lines.

The paper analyzes aging and cancer by profiling ubiquitinome and RNA-seq data in mice, identifying H2A ubiquitination as a marker linked to prognosis and tumor microenvironment.

The paper presents a cryo-EM structure of ZnT8 at low pH, suggesting protons disrupt Zn2+ coordination, aiding its release into the lumen.

The paper reports the first crystal structure of a coronavirus M protein from batCOV5 and identifies its interaction with the N protein.

This study identifies elevated plasma IL-13 and periostin as type 2 inflammatory biomarkers in prurigo nodularis using clustering analysis of cytokine profiling.

This study shows that Zmiz1 is essential for β-cell function and mass expansion in response to high fat feeding, linking its loss to diabetes.

This study develops a stable and safe mRNA vaccine (cmRNA-1130) using degradable lipid nanoparticles against the SARS-CoV-2 Delta variant, showing potent immune responses and stability.

This study shows that dietary glutamine supplementation enhances antitumor immunity by altering the tumor microenvironment in mice with malignant salivary gland tumors.

The paper identifies a novel human antibody VH domain with high affinity for mesothelin and demonstrates its efficacy in both CAR-T cell and antibody drug conjugate formats against mesothelin-expressing cancer cells.

This study identifies a biparatopic VH domain that neutralizes SARS-CoV-2 VOCs, including Omicron, with high potency in vitro and in a mouse model.

This paper identifies ZAKa-driven ribotoxic stress as a mechanism for activating human NLRP1, leading to pyroptosis in response to UVB and microbial ribotoxins.

This study evaluates the functional effects of 21 common sweeteners on human gut microbiomes using metaproteomics, identifying potential prebiotic properties in certain sugar alcohols.

This study identifies a broadly neutralizing antibody fragment and analyzes spike protein mutations in SARS-CoV-2 variants to understand their structural and functional impacts on antibody evasion.

This study investigates how DNA methylation in transposable elements disrupts the link between 3D chromatin organization and gene expression in rice after genome duplication.

This study identifies and validates multiple novel targets of HSV-1 ICP0 in neuronal cells using proteomic approaches and functional experiments, revealing potential restrictive activities of SNX9 and OTUD4.

This study cultivates Akkermansia muciniphila in a dynamic bionic intestinal reactor with different media, finding higher biomass and specific metabolites under human mucin conditions.

This paper develops a novel circular mRNA (C-RNA) platform for cancer therapy, showing it enhances anti-tumor immune responses and improves protein expression through optimized formulation.

This study shows lactate enhances CD8+ T cell stemness and improves anti-tumor immunity by increasing Tcf7 expression through histone acetylation.

The paper identifies auranofin as a drug that lowers leptin levels in white adipose tissue and improves insulin sensitivity in obese mice, with anti-diabetic effects.

This study shows that disrupting rRNA biogenesis in mouse embryonic stem cells induces a 2C-like state through reorganization of peri-nucleolar heterochromatin and activation of the 2C program.

The paper introduces a database that compiles antibody responses and clinical data from COVID-19 patients for analysis and visualization.

This study identifies LENG8 as an mRNA processing factor that regulates mitochondrial activity by controlling mRNA nuclear export and mitochondrial protein expression.

This study shows that complete depletion of linker histone H1 in Arabidopsis disrupts correlations between chromatin compartmentalization, DNA methylation, and gene expression.

This paper develops RNA-based fluorescent sensors to directly image and measure (p)ppGpp in live bacterial cells, revealing cell-to-cell variation and dynamics under different nutritional conditions.

The paper develops the Arabidopsis PeptideAtlas, a proteomics resource integrating mass spectrometry data with metadata and community tools to enhance understanding of the Arabidopsis proteome.

This paper develops a deep learning model to quantify pathological features in kidney transplant biopsies, showing improved prediction of graft loss compared to clinical and Banff scores.

This study shows that the QpH1 plasmid in Coxiella burnetii is essential for colonizing murine macrophages and highlights its role in the bacterium's persistence in rodents.