Z. Zhang

This study presents a chromosome-scale spinach reference genome and resequences 305 accessions to explore evolution, domestication, and genetic basis of agronomic traits.

The paper identifies MOV10 as a new m6A-reader that facilitates mRNA decay via m6A to regulate the WNT/β-CATENIN pathway and maintain mouse embryonic stem cell state.

This study examines how soil quality changes after forest conversion to vegetable cropland and tea plantations, showing contrasting effects on microbial community structure and functions.

The paper reports the discovery of a neutralizing nanobody, VHH60, effective against SARS-CoV-2 and its variants, with high potency and protective efficacy in mice.

This paper introduces EEG-AVE, a model that combines EEG signals with audio-visual data to improve cross-individual affective detection performance.

This study identifies unique hematopoietic features in naked mole-rats, including myeloid bias and quiescent stem cells, linked to their exceptional longevity.

This study shows that naked mole-rats lack thymic involution until midlife and have ectopic cervical thymi with distinct T cell composition compared to mice.

This study identifies two potent monoclonal antibodies against the B.1.351 variant and shows their efficacy against other variants, suggesting their use as an antibody cocktail.

This study shows GC-derived exosomes induce EMT in peritoneal mesothelial cells via TGF-β1/Smads pathway, enhancing GC cell migration and adhesion.

This study shows SAFA interacts with antiviral RNAs to open chromatin and enhance immune gene expression during viral infection.

This study shows TMPRSS2 is a tumor suppressor in lung adenocarcinoma, with its downregulation linked to enhanced antitumor immunity and better response to immunotherapy.

This study shows ARID1A loss activates HERVH, which promotes tumor growth by modulating BRD4-dependent transcription in colorectal cancer.

The paper characterizes human pituitary stem cells using single nucleus RNA-seq and ATAC-seq, revealing distinct cell types, regulatory mechanisms, and age-related differences.

The paper examines genetic and clonal diversity in Leymus chinensis patches, finding strong genetic structure and clonal reproduction within patches.

This paper introduces GraphITE, a deep learning pipeline that transforms multiplex immunofluorescence data into graph embeddings for exploratory analysis of tumor microenvironment patterns.

The paper shows that liver generates NADPH for lipogenesis through serine catabolism, distinct from adipose which uses glucose and the pentose phosphate pathway.

This study examines how TGF-β affects glycosylation patterns in pancreatic cancer cells, identifying N-glycome changes linked to SOX4 expression and SMAD4 deficiency.

This study develops an IFN-armed RBD dimer vaccine that induces strong neutralizing antibodies and T cell responses, offering complete protection against SARS-CoV-2 in rhesus macaques with a single dose.

This study shows E. coli upregulates motility genes at slow growth to maintain flagella number and motility, while larger cell size at fast growth optimizes resource allocation.

This paper introduces a noninvasive optical coherence elastography method to profile cell and tissue mechanical properties using ambient vibrations, validated in silico and in vitro.

This study identifies three ultrapotent SARS-CoV-2 neutralizing antibodies effective against B.1.351 variants, showing synergistic effects and protective efficacy in mice.

This study compares gut microbiota composition between officials in a stable environment and train drivers in a dynamic environment, finding differences in diversity and functional predictions.

This study assesses mangrove vulnerability to coastal anthropogenic disturbances using a spatial framework in mainland China, finding aquaculture as the primary threat.

The paper examines the relationship between mangrove forest fragmentation and salt marsh invasion magnitude across a climatic gradient in southeast China.

The paper analyzes the genome of the estuarine oyster to show how climate history and physical forces shape genomic diversity and adaptive plasticity through gene expansion and regulatory selection.

This study identifies novel SARS-CoV-2 receptors through a CRISPR activation screen, revealing LDLRAD3, TMEM30A, and CLEC4G as functional receptors independent of ACE2.

This study identifies FFPE processing errors in oncology panel sequencing by analyzing variants from technical artifacts in FFPE samples with varying fixation times and block positions.

The paper shows that phagosome cargo degradation is kinetically coupled to their intracellular motility, not stochastic.