Z. Zhang

The paper presents the cryo-EM structure of Drosophila GNPTAB, revealing its catalytic domain and functional residues, and shows dimer interface importance for human GNPTAB activity.

This paper develops a method to create 3D vascularized tissues using bioprinting and surgical anastomosis, showing improved viability and functionality in liver-like constructs.

The paper constructs phylogenetic trees using 8-mer motif sets from genome sequences, finding that CG and TA independent selection patterns reflect different evolutionary states in primates and insects.

This study identifies critical residues for SARS-CoV-2 spike protein binding to ACE2 using machine learning and free energy calculations, showing how specific mutations affect binding affinity.

The paper investigates whether amotosalen, a psoralen used in pathogen inactivation, is a substrate for bacterial multidrug efflux pumps, finding it is pumped out by RND systems in E. coli and Acinetobacter baumannii, potentially reducing its inactivation efficacy against multidrug-resistant pathogens.

This study evaluates antibody resistance and ACE2 usage in SARS-CoV-2 variants, finding SA501Y.V2 shows the highest resistance and expanded host range.

This study compares Brachypodium and Arabidopsis embryo development, finding conserved and divergent transcriptional programs with widespread heterochronic gene expression.

This study presents cryo-EM structures of human ABCA4 in different states, revealing substrate recognition and translocation mechanisms.

This study identifies NAC18.1 as a key gene controlling apple firmness and ripening, showing its functional similarity to the tomato ripening regulator NOR.

This study investigates how PTMs in Nt17 of mutant Httex1 affect aggregation, showing that oxM8 delays aggregation and that combinations with AcK6 inhibit fibrillization, with structural insights from spectroscopy and simulations.

The paper assembles a chromosome-scale, allele-aware autotetraploid genome of alfalfa cultivar Zhongmu-4 and identifies 101 SNPs associated with 27 agronomic traits using GWAS.

This study investigates how the loss of staging habitats affects migration strategies and population dynamics in migratory birds through phenotypic plasticity.

This study develops a selective DYRK2 inhibitor, C17, and identifies novel targets like 4E-BP1 and STIM1, revealing DYRK2's role in protein synthesis and calcium entry.

This study shows R13, a TrkB agonist, improves mitochondrial function and reduces AD-related pathology in 5xFAD mice by enhancing biogenesis and metabolism.

This study develops self-assembling SARS-CoV-2 nanoparticle vaccines that induce protective immunity in mice through subcutaneous and oral administration.

This study analyzes the evolutionary patterns of ACE2 binding affinity to SARS-CoV-2 spike protein across 247 vertebrates and identifies key amino acid mutations driving affinity divergence.

This study evaluates the efficacy of host-directed therapies against the B.1.1.7 SARS-CoV-2 variant and finds similar antiviral activity compared to early-lineage SARS-CoV-2.

The paper identifies HLA-A2 restricted T cell epitopes in SARS-CoV-2 spike protein and finds that variations in these epitopes may reduce T cell activation and contribute to immune escape.

This study shows that adiponectin improves healthspan and lifespan by enhancing insulin sensitivity and reducing age-related metabolic and inflammatory disorders in mice.

This study examines how positive and negative emotions affect false memory using EEG, finding higher false memory rates and distinct brain activation patterns in the positive emotion group.

This study shows IRGM/Irgm1 worsens atherosclerosis by causing macrophage apoptosis via the MAPK pathway, increasing plaque vulnerability and risk of rupture.

This study reports the spontaneous emergence of drug resistance in Cryptosporidium parvum infected calves treated with a methionyl-tRNA synthetase inhibitor, highlighting the potential for anticryptosporidial resistance.

This study characterizes and corrects noise non-uniformity in back-illuminated sCMOS cameras, showing that corrections can improve image quality for microscopy applications.

This study shows that honeybee gut microbiota influences olfactory learning, brain neurotransmitter levels, and metabolism, with parallels to human autism-related gene expression.

The paper introduces an automated algorithm for labelling Neuropixels data using single-channel spike sorting and spatial spike grouping, achieving over 77% accuracy.

This study determines the structure of the Bax core dimer and shows it forms part of the mitochondrial pore wall during apoptosis.

This paper develops a subunit vaccine against SARS-CoV-2 that induces sterilizing immunity in hamsters, with high neutralizing antibody titers and protection against infection and symptoms.

This study shows that honeybee genetics influence gut microbiota composition and strain-level diversity through social transmission, revealing a gut-brain connection.