Y. Li

This study shows peramivir reduces cytokine storm by inhibiting NF-κB activity in macrophages and alleviates lung injury in mice.

This study uses single-cell RNA sequencing to identify five MSC subpopulations, revealing distinct developmental trajectories and functional roles in self-renewal and immunoregulation.

The paper investigates cell-to-cell variability in iCasp9-mediated cell death and identifies initial iCasp9 expression and XIAP/Caspase3 ratio as key factors, showing that combinatorial drugging can reduce drug resistance.

This paper introduces a method to discover rare rabbit monoclonal antibodies against small molecules using an indirect competitive screening approach, resulting in a highly stable antibody with exceptional halophilic properties.

This study identifies TAGLN as a new gene involved in LDL endocytosis through a CRISPR-Cas9 screen and shows its association with plasma lipid levels.

The paper identifies a unique sulfotransferase-involving strigolactone biosynthetic pathway in sorghum involving SbMAX1d and LGS1.

The paper identifies membraneless organelles in bacteria that enhance stress tolerance through liquid-liquid phase separation.

This study shows that fascin promotes lung cancer growth and metastasis by enhancing glycolysis through YAP1-PFKFB3 activation.

This study shows that CD147 antibody inhibits SARS-CoV-2 infection and cytokine storm in variants by blocking viral entry and reducing inflammatory responses.

This study shows a single intranasal vaccination with inactivated Acinetobacter baumannii rapidly protects mice against pneumonia by training alveolar macrophages, with effects observed against other Gram-negative bacteria but not Gram-positive ones.

This study uses single-cell sequencing to analyze immune responses in acute Kawasaki disease before and after treatment, identifying key gene expression changes and immune cell dynamics.

This study compares clonal evolution across right-sided colon cancer, left-sided colon cancer, and rectal cancer patients, finding differences in evolutionary patterns and identifying polyclonal origins of lymph node and extranodal tumor deposits.

This study shows that RANKL from bone marrow adipocytes regulates trabecular osteoclast formation and bone loss in mice, with implications for therapeutic targeting of bone marrow adiposity.

This study identifies SARS-CoV-2 ORF8 as a protein that downregulates MHC-I to evade immune detection by promoting lysosomal degradation, reducing CTL-mediated cell elimination.

This study shows that sensory and corticospinal pathways facilitate, rather than inhibit, sensory feedback in humans by activating nodal GABAA receptors on Ia-afferents.

This paper describes the development of a modified Atezolizumab (Maxatezo) with improved anti-tumor efficacy and reduced anti-drug antibody formation in vivo.

This paper introduces a deep learning method to improve light-field microscopy, enabling high-speed, artifact-free volumetric imaging of biological processes.

This study identifies and characterizes the genetic structure and evolutionary relationships of CPS loci in 40 K-serogroups of Vibrio parahaemolyticus using whole genome sequencing of 443 strains.

This study evaluates how broccoli sprouts and green tea polyphenols, alone or combined, affect gut microbiota and short-chain fatty acids in mice to prevent estrogen receptor-negative mammary cancer.

The paper examines HDP gene expression and tissue distribution in different chicken breeds, finding correlations between body weight, age, and HDP expression in immune organs and intestine.

This paper develops a SARS-CoV-2 proteome microarray to analyze antibody interactions at amino acid resolution and identifies epitopes and neutralizing antibodies in COVID-19 patients.

This paper develops a LAMP assay for rapid detection of the nirS gene in denitrifying bacteria, showing high specificity and sensitivity compared to conventional PCR.

The paper identifies ERG's role in prostate cancer by showing it inhibits basal cell differentiation through chromatin interactions, promoting luminal cell fate.

This paper develops a method to directly synthesize EM-visible gold nanoparticles on genetically encoded tags for single-molecule visualization in cells, achieving high labeling efficiency in both prokaryotic and eukaryotic cells.

This study identifies Na2CO3-responsive proteins and phosphoproteins in alkaligrass, revealing mechanisms for photosynthesis and ROS homeostasis under alkali-salinity stress.

This study characterizes the microbial composition and environmental factors in hotel rooms across continents, finding associations between fungal and bacterial diversity, quantity, and environmental characteristics.

This study shows that exogenous melatonin administration restores diurnal rhythms in gut microbiota and host metabolism in high fat diet-fed mice.

This study generates and tests human embryonic stem cell-derived immunity-and-matrix-regulatory cells (IMRCs) for treating lung injury and fibrosis in mice, showing efficacy and safety.

This study shows that the JE vaccine SA14-14-2 protects mice against ZIKV through cross-reactive T cell immunity rather than antibodies.

This study evaluates how different storage conditions, preservation periods, and sequencing platforms affect gut microbiome profiles using 16S rRNA gene sequencing.