Robert W. Williams

The paper identifies a natural mutator allele in mice that increases C>A germline mutations by 50% due to a variant of the Mutyh gene.

The paper uses linked-read whole-genome sequencing to identify DNA variants in BXD mice and maps them to phenotypes, enabling systems genetics and precision medicine.

This study identifies genetic loci and metabolic factors associated with epigenetic aging in mice, showing links between DNA methylation entropy, diet, and life expectancy.

HiDiver integrates multimodal brain imaging data to enable 3D quantitative analysis of brain structure and function in mice.

SVJAM improves structural variant calling in linked-read data by jointly analyzing multiple samples, recovering missed variants and correcting incorrect types compared to LongRanger.

The paper identifies a Gabra2 variant that increases methamphetamine sensitivity using QTL analysis in mice and validates it with CRISPR correction.

The paper uses multi-omics data from mice to identify gene-environment-age interactions and causal molecular networks linked to longevity.

The paper develops a combined MRI and light sheet imaging approach to generate high-resolution brain phenotypes for neurogenetic studies in mice.

The paper examines how diet and genetics interact to affect longevity and weight gain in mice, finding that genetic differences significantly influence the impact of high-fat diets on lifespan.

The paper develops GPU-accelerated algorithms for fast eQTL scans in BXD mice, reducing runtime to seconds for large transcriptome datasets.

The paper quantifies heritability of THC responses in BXD mice strains and identifies candidate genes associated with variation in initial sensitivity to THC effects.

The paper uses whole genome sequencing to compare nearly isogenic WMI and WLI inbred rats, identifying genetic variants associated with depression and stress-related traits.

The paper identifies Tti2 as a gene influencing both adult hippocampal neurogenesis and serum glucose levels using a rat genetic model.

This study identifies Gabra2 as a genetic modifier of Dravet syndrome in mice by showing that a deletion in Gabra2 worsens seizure and survival phenotypes in Scn1a+/- mice, which is reversed by repairing the deletion.

The paper identifies Pttg1 as a key regulator of gene expression variation in mouse ventral midbrain across aging, showing its role in transcriptome shifts and cell-type-specific changes.

GeneCup mines PubMed for gene relationships using a custom ontology and deep learning to organize and present relevant literature and GWAS results.

This study examines the relationship between body weight, epigenetic aging, and lifespan in BXD mouse strains, finding that higher body weight and high-fat diet accelerate epigenetic aging and shorten lifespan.

The paper presents two computational methods to reduce contamination in single-cell RNA-seq data, improving clustering and biological interpretation.

The paper identifies Col4a6 as a genetic regulator of striatal dopamine levels and axonal branching in mice through QTL mapping and RNA-seq analysis.

This study examines the heritability of mouse brain connectomes using high-resolution MRI and finds high heritability in brain volumes and diffusion metrics.

The paper introduces GeneBridge, a method for imputing gene function and predicting module connections using multi-species expression data, and demonstrates its application across 1,700 datasets.

The paper uses high-resolution imaging and QTL analysis to study genetic control of bone microarchitecture in mice, identifying 50 candidate genes with potential roles in bone biology.

The paper identifies Kcnn3 as a pharmacogenetic target for reducing ethanol drinking and anxiety-like behaviors in stressed, ethanol-dependent mice.

BXD mouse family doubled to 150 inbred strains segregating over 6 million variants, with roughly 10,000 located recombinations and a public phenome exceeding 7000 traits.

The paper identifies a functional non-coding variant in the GABRA2 gene of the C57BL/6J mouse strain, showing its impact on Gabra2 expression and implications for neuroscience research.

The paper generates high-resolution genetic maps of mouse inbred strains and identifies genetic variations and gene conversions.