Author

Shadmehr Demehri

Harvard UniversityORCID 0000-0002-7913-2641Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Approach:genetic perturbation / CRISPR· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

Allison P. Vanasse· 1 shared Alvaro Quintanal Villalonga· 1 shared Ana FiszbeiniD· 1 shared Andriana ManousidakiiD· 1 shared Angeliki KaratzaiD· 1 shared Angelina M. CicerchiaiD· 1 shared Anupa GeethadeviiD· 1 shared Åsa SegerstolpeiD· 1 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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1 shared paperCancer Biology

Allison P. Vanasse

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

CoREST Complex Inhibition Alters RNA Splicing to Promote Neoantigen Expression and Enhance Tumor Immunity

Robert J. Fisher, Kihyun Park, Kwangwoon Lee, Katarina Pinjušić, Allison P. Vanasse, Christina S. Ennis, Parisa Farokh, Scott B. Ficarro, Jarrod A. Marto, Hanjie Jiang, Eunju Nam, Stephanie Stransky, Joseph Duke-Cohan, Melis A. Akinci, Anupa Geethadevi, , Rhoda M. Alani

The paper shows that inhibiting the CoREST complex with corin alters RNA splicing, increases neoantigen expression, and enhances tumor immunity in melanoma.

JCI Insight · Dec 9, 2025Peer-reviewedCancer Biology

CREB5 promotes immunotherapy resistance via tumor-intrinsic collagenmatrix deposition

Payal Tiwari, Kayla J. Colvin, Sarah Y. Kim, Ashwin V. Kammula, Jordan M. Chinai, Nuno Alfaiate, Or‐Yam Revach, Erin N. Kistler, Seoyun Heo, Seth Anderson, Sydney M. Moyer, Zhengyang Sun, Angelina M. Cicerchia, Claire A. Palin, Maulik Vyas, , Robert T. Manguso

The paper identifies CREB5 as a driver of immunotherapy resistance in melanoma by promoting collagen matrix deposition, which activates LAIR1 signaling on immune cells.

bioRxiv · Apr 22, 2025 · PreprintCancer Biology

SOX2-induced IL-1alpha-mediated immune suppression drives epithelial dysplasia malignant transformation

Hülya F. Taner, Wang Gong, Zackary R. Fitzsimonds, Zaiye Li, Yuesong Wu, HE Yu-min, Kohei Okuyama, Wanqing Cheng, Jung M. Kuczura, Sashider Rajesh, Andriana Manousidaki, Shuo Feng, Miki Lee, Felipe Nör, Emily Anne Lanzel, , Yu L. Lei

This study identifies a SOX2-CCL2-IL1 pathway that drives immune suppression in precancerous epithelial dysplasia, promoting malignant transformation.

bioRxiv · Dec 6, 2024 · PreprintCancer Biology

Inference of single cell profiles from histology stains with the Single-Cell omics from Histology Analysis Framework (SCHAF)

Charles S. Comiter, Xingjian Chen, Eeshit Dhaval Vaishnav, Koseki J. Kobayashi-Kirschvink, Metamia Ciampricotti, Ke Zhang, Jason Murray, Francesco Monticolo, Jianhuan Qi, Ryota Tanaka, Sonia E. Brodowska, Bo Li, Yiming Yang, Scott J. Rodig, Angeliki Karatza, , Aviv Regev

SCHAF generates spatially resolved single-cell transcriptomes from H&E histology images using vision transformers and adversarial learning, showing good agreement with ground-truth data.

bioRxiv · Mar 21, 2023 · PreprintBioinformatics