transcription & RNA processing

This study introduces a new bioprinting method using a yield-stress granular gel to position and assemble tissue spheroids in 3D for cartilage and bone tissue construction.

This study reannotates the VZV transcriptome using RNA sequencing to identify 136 polyadenylated RNAs, including ORFs, non-canonical ORFs, ORF fusions, and ncRNAs, revealing unexpected kinetic classes of viral transcripts.

This study develops biofabricated myo-substitutes to restore skeletal muscle mass, 3D structure, and function in volumetric muscle loss models.

This study quantifies HSV-1-induced host shut-off mechanisms and identifies gene-specific transcriptional changes during early infection.

This paper develops a thrombin-free method to polymerize fibrinogen into gels, enabling controlled processing and new applications in tissue engineering.

This study shows ARID1A has opposite roles in promoting neural differentiation and suppressing cardiac differentiation from human pluripotent stem cells.

This paper introduces POP-seq, a method to profile bacterial nucleoid openness, linking genome structure to transcriptional and phenotypic outcomes.

This study develops 3D scaffolds with antibiotic-loaded inorganic fillers for bone infection prevention and tissue regeneration, showing sustained antibiotic release and compatibility with cell differentiation.

PerSort isolates and characterizes persister subpopulations in Mycobacterium tuberculosis, revealing their multidrug tolerance and metabolic state, and enabling their elimination under stress conditions.

This paper identifies PtrR as a dual activator/repressor in E. coli that regulates putrescine stress response and glutamate utilization through transcriptional control of multiple genes.

The paper shows that exonic stem-loops upstream of introns regulate splicing by modulating splicing factor accessibility.

This study identifies nuclear myosin VI as a molecular anchor for RNA Polymerase II clusters, showing its role in maintaining transcription factory organization and gene expression.

The paper uses SARS-CoV-2 genome sequencing and agent-based modeling to estimate local transmission rates during the early stages of the COVID-19 outbreak in New South Wales.

This paper shows that the THO/TREX complex components TEX1 and HPR1 are required for proper transcription termination in Arabidopsis, leading to defects in mRNA processing and growth.

This study shows that SERRATE interacts with the NEXT complex to degrade primary miRNA precursors in Arabidopsis, revealing a dual role for SERRATE in miRNA biogenesis.

The paper uses imaging techniques to show that splicing occurs in a slow-moving zone near the transcription site, suggesting a model where splicing is post-transcriptional but occurs close to transcription.

This study shows O-GlcNAc modification regulates detained intron splicing, affecting gene expression and linking nutrient conditions to transcriptional regulation.

This study identifies E proteins as suppressors of ILC2 differentiation by repressing a transcriptional network through upregulation of repressor genes.

The paper examines how photoperiod affects the transcriptional response to seawater entry in Atlantic salmon, finding that short photoperiod impairs hypo-osmoregulation and alters gill gene expression.

The paper shows Gβγ interacts with RNA polymerase II in cardiac fibroblasts, negatively regulating fibrotic gene expression, with cell-specific signaling pathways involved.

This study synthesizes and characterizes a methacrylated bone-derived hydrogel (BoneMA) for bioprinting vascularized tissues, showing its cytocompatibility and ability to form vascular networks.

This paper introduces a 3D-printed modular LEGO-like cage scaffold system for tissue engineering that allows scalable assembly and controlled therapeutic loading.

This study shows that mTOR hyperactivation causes widespread exon skipping, leading to diverse proteomic changes through alternative splicing in both 5’-UTR and coding regions.

The paper identifies colocalization of G-quadruplex forming sequences and m6A modifications at human pre-mRNA intron splice sites, suggesting a potential role in alternative splicing.

This paper introduces an APEX2-based method to map proteins, RNA, and DNA associated with the nuclear lamina, revealing new insights into its regulatory roles and dynamic interactions.

The paper identifies PRS4 as a regulator of TOR activity in plants, showing TOR coordinates nucleotide availability with ribosome biogenesis to support growth.

This study uses ultrafiltration to separate extracellular vesicles from MSC secretome, showing EVs and non-EV components both contribute to tissue regeneration in vivo.

This study shows that temporarily stopping CAR-T cell signaling can reverse exhaustion and improve their anti-tumor function through transcriptional and epigenetic changes.

This study identifies DRB1 as a transcriptional regulator that interacts with RNA Polymerase II and transcription factors, influencing MIR gene expression and plant light response genes.

This paper introduces a chemical method to block RNA polymerase transcription in E. coli using DNA modifications, enabling stable nascent RNA display in minimal in vitro reactions.