Tuberculosis Research and Epidemiology

This paper develops fluorinated trehalose analogues to label and visualize Mycobacterium tuberculosis, showing their uptake correlates with substrate recognition and enabling pathogen-specific detection.

This paper evaluates the adjunctive effect of the HO-1 inhibitor stannsoporfin in combination with a novel MDR-TB regimen in a murine model, showing reduced lung bacillary burden but no effect on microbiological relapse.

The paper identifies two non-canonical L-cysteine synthases in Mtb, CysM and CysK2, which support divergent biosynthetic pathways critical for redox stress response and survival during infection.

This study integrates multi-omics data from bovine and human macrophages infected with M. bovis and M. tuberculosis to identify genes and pathways associated with resistance to mycobacterial infection.

This study investigates ESAT-6's self-association under acidic conditions and shows an ESAT-6-specific nanobody inhibits M. tuberculosis growth in macrophages.

This paper evaluates a modified BPaL regimen replacing linezolid with inhaled spectinamide 1599 for tuberculosis treatment, showing similar efficacy while avoiding linezolid-associated adverse events.

This study compares the effects of benzothiazinone (BTZ) and ethambutol (EMB) on the corynebacterial cell envelope, showing BTZ preserves membrane integrity while EMB disrupts it.

The paper reports a case of prolonged survival in an HIV-co-infected patient with MDR-TB, linked to a unique genomic deletion in the Mtb strain.

This study identifies preferential differential gene expression in WC1.1+ γδ T cells from cattle naturally infected with Mycobacterium bovis, highlighting immune-related functions.

fastlin rapidly and accurately types Mycobacterium tuberculosis complex lineages from sequencing data, detecting mixed-lineage strains and estimating proportions.

The paper examines transmission rates of borderline and common rpoB mutations in MDR-TB isolates from Bangladesh, finding no difference in transmission clustering between mutation types.

The paper evaluates DNA decontamination methods and a new target enrichment protocol to improve Mycobacterium tuberculosis whole-genome sequencing from direct patient samples.

This paper develops DrPRG, a tool for predicting drug resistance in Mycobacterium tuberculosis using reference graphs, showing improved sensitivity and specificity compared to existing methods.

The paper uses transposon mutagenesis and QTL mapping to identify host-pathogen genetic interactions affecting Mtb fitness in immunodivergent mice.

The paper identifies bacterial genomic variants and a mutational signature associated with poor treatment outcomes in drug-susceptible tuberculosis, while showing host factors are more important in prediction models.

This paper identifies genetic variants and eQTLs associated with TB severity, linking them to vascular biology and inflammation, using GWAS and eQTL analyses in TB patients.

The paper constructs a whole genome co-expression network from Mycobacterium tuberculosis transcriptomic data to identify and prioritize unannotated expressed transcripts for functional analysis.

The paper presents streamlined methods for generating circular DNA from the rv0678 gene to improve genotypic bedaquiline resistance testing in Mycobacterium tuberculosis.

This study evaluates two bioinformatics tools for analyzing MTBC sequencing data, finding high concordance with phenotypic testing and high agreement in lineage determination.

The paper shows Mtb infection triggers a type I interferon response through chromatin remodeling, with PPM1A affecting chromatin accessibility and gene expression.

The paper identifies gene pathways associated with neutrophil and platelet responses that are activated up to six months before TB diagnosis in whole blood.

This study shows that Rv1019, a transcriptional regulator in M. tuberculosis, is upregulated under hypoxia and negatively regulates an operon involved in oleic acid biosynthesis.

The paper identifies genetic risk factors for tuberculosis, including HLA alleles and INPP5A variants, and shows smoking as a lifestyle risk factor.

The paper identifies a 170-gene transcriptional signature in bovine peripheral blood post-M. bovis infection following PPD-b stimulation, suggesting potential biomarkers for bTB diagnostics.

This paper develops a QSP framework to evaluate metformin's effect on autophagy in tuberculosis, showing limited but dose-dependent benefits in reducing bacterial load and inflammation.

The paper uses whole-genome sequencing to analyze Mycobacterium tuberculosis population structure and transmission patterns in Mozambique, finding recent transmission and endemic clades linked to HIV/TB coinfected patients.

This paper presents a deep convolutional neural network to predict antibiotic resistance in M. tuberculosis isolates, achieving state-of-the-art accuracy and enabling interpretable feature analysis.

This study finds that higher Native Peruvian ancestry is associated with increased tuberculosis progression risk, independent of socio-demographic and environmental factors.

The paper identifies mutations conferring resistance to Macozinone in Mycobacterium tuberculosis through in vitro selection and whole genome sequencing.