Neurotransmitter Receptor Influence on Behavior

RTFED provides real-time, remote monitoring of mouse feeding and operant behaviors with video and fiber photometry recording, improving accessibility and reducing animal disturbance.

This study investigates the role of RMTg-VTA pathway stimulation in avoidance learning by testing its effects on reward seeking and choice behavior in rats.

The paper identifies genetic loci affecting cocaine sensitivity in Collaborative Cross mouse strains through QTL mapping and proposes candidate genes for further study.

This study examines the role of the 5-HT3A receptor in behavioral persistence and flexibility by comparing wild-type and knockout mice in operant conditioning tasks.

This study shows that striatal matrix neurons in mice respond before licking onset and are involved in preparing for licking and regulating its frequency during drinking.

This study investigates the role of LH-GABA neurons in encoding both alcohol reward and aversive memories, revealing their involvement in learning and conflict between appetitive and aversive outcomes.

This study investigates the role of superior colliculus projections to dopamine neurons in rats, showing they drive movement-related behaviors like head turning but not reward-based learning.

This study compares sex differences in voluntary ethanol consumption and negative affective behaviors in mice starting ethanol intake during adolescence versus adulthood, finding reduced sex differences in adolescent-onset drinkers.

This study identifies a subtype of striatonigral neurons that modulate locomotor speed based on environmental valence in mice.

This study examines how punishment cues affect decision-making in rats, showing sex differences and the impact of psychostimulants.

This study identifies a subtype of striatonigral neurons that regulate locomotion speed based on environmental valence through genetic and optogenetic manipulations in mice.

This paper uses machine learning on fMRI data to predict craving intensity in methamphetamine users, achieving significant results with PCA and linear regression.

The paper shows that dopamine neurons in the mesolimbic pathway encode the value of water and salt in a state-dependent manner, influencing behavior and simulated by a reinforcement learning model.

This study shows that nandrolone exposure before puberty in male rats reduces anxiety, alters cocaine-induced locomotor sensitization, and changes dopamine receptor expression in striatal and cortical regions.

This study shows that aging reduces motivation in mice by decreasing Bdnf expression in the ventral tegmental area, and that this effect can be replicated by Bdnf knockdown in young mice.

The paper examines behavioral variation in cocaine self-administration across multiple phases in genetically diverse mouse populations, identifying strain and sex differences and extreme strains for drug intake traits.

This study identifies the role of kappa opioid receptors in stress-induced cocaine seeking by showing their effect on GABAergic synapses in the ventral tegmental area.

This study investigates the separate roles of CRF and GABA release from BNSTCRF neurons in ethanol self-administration in mice, finding CRF deletion reduces ethanol intake while GABA suppression affects motivation differently in males and females.

The paper identifies differentially expressed genes in the nucleus accumbens of aggressive male mice after fighting deprivation, linking them to behavioral pathology and aggression relapse.

This study shows that dopamine neuron prediction error signaling for reward value and identity depends differently on the hippocampus and orbitofrontal cortex in rats.

This study shows that mesolimbic dopamine ramps occur only when inter-trial intervals are short relative to trial periods during conditioning.

This study links tonic dopamine levels to biased value learning through a reinforcement learning model incorporating dopamine receptor dynamics, showing its relevance to psychiatric disorders.

The paper compares three methods for analyzing spontaneous dopamine signals and finds that z-scoring is unreliable, while manual and prominence methods are more accurate.

This study shows that dopamine signaling in the VTA-mPFC circuit is essential for rapid threat avoidance learning, with transient dopamine activity encoding aversive outcomes and predictive cues.

This paper develops a head-fixed ethanol self-administration model in mice, demonstrating reliable ethanol-seeking behavior and relapse-like reinstatement of lever pressing.

The paper identifies distinct roles of three DRN dopamine neuron projections in social behavior and affective states through optogenetic and electrophysiological experiments.

This study examines how VTA dopamine and GABA neurons adapt to reward and punishment contingency shifts in rats, revealing distinct roles in behavioral flexibility.

This study shows that dopamine in the nucleus accumbens reflects decision confidence and future value during re-evaluation and change-of-mind in mice.

This study uses computational modeling and optogenetics to show that dopamine neuron stimulation promotes learning, supporting the prediction error hypothesis over the rewarding value hypothesis.

This paper investigates how 5-HT2C receptors in the nucleus accumbens modulate MDMA's rewarding effects and prosocial behaviors through interactions with serotonin and dopamine release.