Malaria Research and Control

This study shows that latent cytomegalovirus infection reduces antibody responses to malaria infection and vaccination by altering Tfh cell subsets and their activation.

This study identifies PfDMT1 as a critical iron transporter in malaria parasites, showing its essential role in iron acquisition and its potential as a therapeutic target.

This paper develops a self-cooling, self-humidifying backpack to transport live adult mosquitoes over long distances in challenging field conditions, achieving high survival rates comparable to controlled environments.

This study identifies PfSET10 as a H3K18 methyltransferase in Plasmodium falciparum that regulates chromatin structure and is essential for intraerythrocytic development.

This study shows that PfSET10 is not required for var gene expression, antigenic variation, or blood stage parasite survival.

The paper shows that RNA Polymerase I inhibitors affect different Pol I-transcribed genes in Plasmodium falciparum by varying degrees, with some genes being much more sensitive than others.

This study uses human iPSC-derived neuronal cultures exposed to hemozoin to show activation of DNA damage, p38 MAPK, and neurodegenerative pathways similar to cerebral malaria.

This study shows that host 5-HT levels influence Plasmodium transmission in mosquitoes by modulating mitochondrial homeostasis and reactive oxygen species.

This study characterizes the spatial and temporal flight kinematics of Anopheles coluzzii swarms, showing stereotypic shape and density patterns and modeling swarm structure based on visual perception.

This study shows that PP7 is essential for early ring-stage development in Plasmodium falciparum but not for erythrocyte invasion.

The paper analyzes whole-genome-sequenced Plasmodium falciparum samples to understand gene deletions associated with malaria rapid diagnostic tests, identifying patterns of chromosomal rearrangements and duplication.

The paper introduces MoTissU-ExM, a method to expand mosquito tissues for visualizing malaria parasites, enabling ultrastructural analysis of both host and parasite structures.

This study investigates heterochromatin dynamics during early sexual development in Plasmodium falciparum, showing that major changes occur at stage II/III and that transcriptional changes precede heterochromatin modifications.

MOIRE, a Bayesian R package, jointly infers allele frequencies, multiplicity of infection (MOI) and within-host relatedness from SNP or polyallelic malaria genotypes, yielding a panel-portable effective MOI.

This paper identifies MED6-189, a potent antimalarial compound that disrupts apicoplast function and vesicular trafficking in P. falciparum, showing efficacy against drug-resistant strains and demonstrating a unique mechanism of action.

This study examines morphological changes in apicoplasts of P. falciparum persisters after drug treatment, finding that apicoplasts become enlarged and irregularly shaped during dormancy, with variations in shape and positioning over time.

This study details the division and segregation of mitochondria and apicoplasts in Plasmodium falciparum using imaging and microscopy techniques.

This study shows that RON11 is essential for the biogenesis of the second rhoptry in Plasmodium falciparum merozoites and is required for erythrocyte invasion.

The paper investigates insecticide resistance and population structure in Anopheles gambiae from southern DRC, finding high resistance and genetic differentiation between populations.

The paper uses whole-genome sequencing of malaria vectors to track the emergence and spread of new insecticide resistance variants over time in Burkina Faso.

AnophelesModel integrates mosquito and human data to assess malaria intervention impacts across regions.

The paper develops a high-content imaging assay to identify Plasmodium liver stage protein synthesis inhibitors and identifies two quinoline-4-carboxamides with distinct antiplasmodial and translation inhibition profiles.

This study shows that apicoplast-derived isoprenoids are essential for GPI anchor biosynthesis in Plasmodium falciparum, which is critical for parasite egress and invasion.

The paper investigates the spatiotemporal roles of three Aurora-related kinases in Plasmodium falciparum mitosis and gametogenesis, revealing distinct functions in cell division processes.

This paper designs a malaria vaccine immunogen using structure-guided methods to present a single epitope from PfRH5, showing improved antibody response in rats compared to PfRH5 alone.

This study evaluates the regeneration time, efficacy, and wash-resistance of PermaNet(R) Dual against susceptible and pyrethroid-resistant Anopheles gambiae strains, showing it meets WHO efficacy criteria and performs well against resistant strains.

This study shows that Plasmodium falciparum complex III is essential for asexual stage survival and gametocyte maturation, supporting its role as a drug target.

The paper compares immune gene expression changes during a malaria transmission season versus between seasons in children with P. falciparum infections.

This study challenges existing mathematical models of malaria infection dynamics by showing RBC supply and clearance do not conform to common model assumptions.