Malaria Research and Control

This study assesses the prevalence and geographic distribution of pfkelch13 mutations linked to artemisinin resistance in Africa through a systematic review and meta-analysis of observational cohorts.

This study identifies a mutation in PfAQP and duplication of superoxide dismutase genes as mechanisms of resistance to cryptosporin in Plasmodium falciparum.

This study characterizes the structure and function of antibodies targeting the conserved β-epitope region of PfCSP, showing how they achieve strain-transcending recognition and enhance Fc-mediated immune responses.

This study shows doxycycline inhibits apicoplast and mitochondrial translation in Plasmodium falciparum and Toxoplasma gondii, reducing protein abundance and mitochondrial complex IV activity.

The paper uses the ANOSPP amplicon panel to analyze Anopheles mosquitoes and Plasmodium species in Tanzania, revealing 15 Anopheles taxa and five Plasmodium species, including new records of P. caprae and An. funestus-like mosquitoes.

This study demonstrates the antimalarial and immunomodulatory effects of Himalayan Buransh in vitro, in vivo, and in silico, showing potential as an adjunct therapy for drug-resistant malaria.

This study identifies CNBP's role in regulating the IL12β-IFN-γ axis during Plasmodium infection, showing its importance in immune control and potential as a therapeutic target.

This study uses whole-genome sequencing to analyze genomic connectivity and adaptive gene flow of insecticide resistance alleles in Anopheles arabiensis across East Africa, revealing transboundary spread despite geographic barriers.

This study uses scRNA-seq to analyze Plasmodium falciparum transcript responses to three drugs, revealing distinct transcriptional profiles and feedback regulation.

This study identifies MaRNAV-1 as an intracellular virus in Plasmodium vivax that increases transmission and alters host immune responses.

This study identifies PfMD3 as an RNA-binding protein that regulates male gamete fertility by impacting translation in Plasmodium falciparum.

This study identifies distinct roles of TRAP and TRP1 adhesins in Plasmodium sporozoite motility and invasion, showing differential signaling requirements for gliding and transmission.

This study investigates the role of Plasmodium Alp3 and Alp5a in mosquito infection, finding that Alp5a is critical for sporozoite formation and oocyst development, while Alp3 is essential for ookinete penetration.

This paper introduces PfPan, a P. falciparum pangenome that improves structural variant detection and aids malaria control by identifying drug resistance and diagnostic evasion variants.

This study investigates why the ClpM gene remains in the apicoplast genome of malaria parasites, finding that it is constrained by evolutionary, sequence, and translational factors.

The paper identifies a putative metal transporter in the apicoplast of malaria parasites, showing it is essential for gametocyte development but not asexual stages.

The paper analyzes amino acid substitutions in nAChR subunits of Anopheles funestus to identify rapid evolution in α9 and β2 subunits under insecticide selection pressure.

This paper introduces a Bayesian framework for inferring transmission networks from polyclonal infections, demonstrating its application to Plasmodium falciparum with high precision and recall in simulations.

This study shows that short-term ex vivo culture of Plasmodium vivax enriches late asexual stages and selectively filters clones without inducing major transcriptional changes.

The paper identifies genomic signatures of selection in Anopheles funestus across African populations, revealing shared and population-specific adaptive variation linked to insecticide resistance and neuromodulatory pathways.

This study shows that Plasmodium falciparum extracellular vesicles modulate host MAP kinase signaling to enhance cytoadherence, with virulent strains promoting this effect through miRNA-mediated suppression of PTPRR.

The paper tracks malaria parasite lineages using de novo mutations in Plasmodium falciparum genomes from community infections in The Gambia, identifying recent mutations and transmission patterns.

This study shows that targeting PTRAMP-CSS inhibits Plasmodium falciparum across liver, blood, and mosquito stages, supporting its potential as a multistage vaccine target.

This study identifies EGF7 in PfRipr as a critical domain for inhibiting Plasmodium falciparum erythrocyte invasion and provides a basis for vaccine design.

The paper identifies temporal expression patterns of liver-stage malaria antigens and shows that combining antigens with different temporal profiles improves vaccine efficacy.

This paper identifies AgMOBP1 and PfSyn5 as a critical mosquito-parasite interface for malaria transmission and shows antibodies against PfSyn5 can completely block transmission at low concentrations.

This study develops a self-amplifying RNA vaccine against Plasmodium falciparum malaria that induces high functional antibodies with Fc-mediated activities using a dose-sparing regimen.

The paper identifies VAR2CSA-specific monoclonal antibodies that synergistically enhance phagocytosis of malaria-infected red blood cells when combined, but none inhibit CSA binding.

This study shows that severe malarial anaemia is linked to increased red blood cell production, iron metabolism, tissue injury, and parasite biomass in bone marrow, with better resolution from bone marrow analysis than peripheral blood.