HIV Research and Treatment

QuickFit quantifies viral growth and fitness in vitro using high-throughput RT-qPCR, offering higher throughput and lower error than traditional methods.

This study identifies how cocaine activates DNA-PK, which promotes HIV transcription by relieving RNAP II pausing through TRIM28 phosphorylation.

This study links elevated IL-1β and IL-18 levels with gut barrier disruption and monocyte activation in SIV-infected macaques on long-term ART, suggesting a role in CVD and metabolic complications.

This study evaluates glycoengineered HIV-1 trimers to enhance bNAb recognition, finding that B4GalT1+ST6GalT1 modifications increase antibody titers in infected donors but reduce vaccine-induced neutralizing antibodies.

This study shows metformin reduces HIV-1 virion release and increases antibody recognition of infected CD4+ T-cells by modulating BST2 and Bcl-2 expression in HIV-positive individuals on ART.

This study examines transcription of HIV-1 at sites of intact latent provirus integration in T cells, finding that latent proviral promoters are significantly less active than in productively infected cells and have minimal impact on neighboring gene expression.

The paper uses dynamic models to analyze viral rebound after HIV-1 treatment interruption, showing effector cell expansion rate distinguishes post-treatment controllers from non-controllers.

The paper shows that Arg18 substitutions in HIV-1 capsid protein lead to non-fullerene capsid assembly with unique structural features.

The paper analyzes HIV-1 entry kinetics across 257 isolates, identifying single-residue determinants and showing cooperative sequential roles of co-receptor engagement and gp41 function in entry.

This study compares the nuclear interactomes of HIV-1 and RSV Gag proteins, identifying shared and unique host factors involved in nuclear processes like transcription and chromatin remodeling.

This study shows PARP-1 deficiency or inhibition increases HIV-1 replication in human CD4+ T cells by enhancing viral infectivity and virion-associated Env levels.

This study investigates how Importin beta-1 packaged in HIV-1 virions affects viral infectivity and transcription, revealing its dual role as both a facilitator and restriction factor.

This study identifies how TREX1 preferentially degrades unprocessed HIV-1 DNA over 3-processed DNA through kinetic, thermodynamic, and structural differences.

This study examines how early ART initiation in HIV-infected infants affects antibody development and latent reservoir dynamics, showing their opposing impacts on post-treatment viral rebound.

This study examines how antiretroviral treatment affects immune responses in the brain and blood of EcoHIV-infected mice, identifying treatment-induced changes in cytokine and chemokine expression.

This study shows that monocyte-to-macrophage differentiation and redox changes influence HIV latency differently in cell types, with macrophages being more responsive to redox modulators.

This paper shows HIV-1 Vpr causes separate G2 and M phase cell cycle arrests that activate distinct DNA damage pathways, with implications for early HIV replication.

The paper identifies novel protein and RNA interactions of APOBEC3 enzymes, revealing deamination-independent roles in RNA biology and cancer.

The paper shows that myristoyl exposure in M-PMV matrix protein triggers structural changes leading to efficient cleavage of Gag polyprotein.

HIHISIV is a database that integrates and provides tools to analyze gene expression data from HIV and SIV host immune responses in humans and nonhuman primates.

This study investigates whether engineering HIV Env trimers or using gp120 can induce broadly neutralizing antibodies in cows, finding that trimers are more effective than monomeric gp120.

This study shows HIV integrase compacts viral DNA into biphasic condensates, with the core susceptible to inhibitors and the outer layer resistant.

This study examines changes in immune checkpoints and senescence markers in HIV-positive individuals post-COVID-19 infection, finding elevated levels of several biomarkers in those previously infected.

The paper measures the stoichiometry of Gag-Pol and gp120/gp41 proteins in infectious HIV-1 virions using a competitive assembly method, finding it similar to all released virions.

This study shows HIV-1 integrates near R-loops in the host genome, linking viral integration to R-loop formation and suggesting new therapeutic strategies.

This study identifies CD34+ monocytes as highly susceptible to HIV-1 infection, showing they harbor more proviral DNA and express higher HIV-1 receptors despite cART.

This study develops a HSV-vectored therapeutic vaccine that reactivates SIV latency and elicits immune responses, delaying viral rebound in SIV-infected macaques.