Influenza Virus Research Studies

The paper identifies genetic signatures in influenza A viruses associated with interspecies transmission between swine and humans using phylogenetic analysis and machine learning.

This paper tracks the evolution and epidemiology of H3N2 canine influenza virus over 20 years in dogs, showing it evolves at a constant rate and spreads rapidly in dense populations but requires long-distance dispersal to sustain outbreaks.

This study examines cytokine levels in serum during acute respiratory infection and their relationship to age, finding elevated pro-inflammatory cytokines in infected individuals and age-related trends in healthy cohorts.

The paper quantifies neutralizing antibody responses to influenza strains using sera collected in 2024-2025 to inform vaccine-strain selection for 2025.

This study uses deep mutational scanning to analyze the functional impact of NEP mutations in influenza A virus, revealing pleiotropic effects on viral replication and host adaptation.

This study assesses serological protection against H5N1 and H7N9 avian influenza viruses and evaluates the effectiveness of seasonal flu vaccines in inducing protective immunity.

This study shows that human ANP32A/B are SUMOylated, enabling avian influenza virus NS2 to enhance polymerase activity and overcome species-specific restrictions.

The paper demonstrates that the GreFluVie5 vaccine, based on a fully deleted adenoviral vector, fully protects mice against lethal H5N1 influenza virus challenges.

This study identifies a single mutation in H5N1 viruses from dairy cows that increases receptor binding breadth to avian receptors, suggesting potential for expanded host range.

The paper reports the whole-genome analysis of an HPAIV H5N1 clade 2.3.4.4b virus found in a kelp gull in Antarctica, showing its genetic similarity to strains in South American pinnipeds and seabirds.

The paper detects a reassortant H3N2 influenza A virus in farmed mink in British Columbia, linked to swine and human origins, highlighting zoonotic risks and the need for surveillance.

This study compares replication and pathogenicity of cattle-origin H5N1 influenza viruses in mammals and birds, finding higher replication efficiency and pathogenicity in human-adapted isolates.

The paper analyzes T cell epitopes from H5N1 and seasonal influenza viruses, finding conserved epitopes and cross-reactivity, suggesting pre-existing immunity may reduce H5N1 severity.

This study shows that equine H3N8 vaccine induces broad protection against influenza in multiple animal models, including neutralizing antibodies against diverse viral strains.

This paper tests DDO268 as an adjuvant for an influenza A virus nucleoprotein mRNA vaccine in mice, showing enhanced immune responses and protection against viral challenge.

This paper designs chimeric influenza hemagglutinins that combine antigenic surfaces from different strains to elicit cross-group immunity and neutralize multiple strains.

This study shows that an Ascophyllum nodosum extract inhibits influenza virus infection by targeting virions and neuraminidase activity, reducing viral load in mice.

This study tracks the emergence and spread of a new H1N2 1C genotype in French swine influenza viruses, showing its rapid dominance and antigenic changes.

This study compares the ability of seasonal H1N1 and H3N2 influenza A viruses to antagonize interferon induction and signaling at the single-cell level, finding differences in their IFN antagonism potential.

The paper analyzes influenza virus infections in ferrets to assess the trade-off between fatality and transmissibility using cumulative viral titers as a proxy for secondary transmission.

This study shows influenza A viruses use a burnt-bridge Brownian ratchet mechanism for directed motion through mucus, operating in an optimal parameter range due to evolutionary adaptation.

The paper evaluates the antigenic evolution of N1 neuraminidase in H1N1 influenza viruses from 2009 to 2020, identifying key mutations driving antigenic changes and their impact on antibody neutralization.

This study examines how immune history affects antibody responses to influenza H1N1 hemagglutinin and neuraminidase in mice, finding that HA responses are more restricted by prior infection than NA responses.

This study develops CD-SA, a β-cyclodextrin-based nanomaterial that acts as a potent broad-spectrum antiviral against influenza A and B viruses, showing higher efficacy than Oseltamivir in ex vivo and in vivo tests.

The paper develops a rapid neutralization assay for H5N1 influenza virus in cows and shows cross-reactivity of antibodies against circulating H5N1.

This study analyzes the molecular epidemiology of Influenza A and B viruses in Brazil from 2021 to 2023, revealing lineage dominance patterns and mutations that may impact vaccine efficacy.

This study tracks AIV infection and immunity in urban ducks before and during an H5N1 outbreak, finding population-wide infections and waning immunity over time.

The paper shows that L-glutamine decomposition and ammonium accumulation in cell culture media inhibit influenza virus infectivity, with effects varying by media type and viral strain.

This paper develops a physical model explaining how M1 protein polymerization into helices facilitates efficient influenza A virus assembly and membrane deformation.