Developmental Biology and Gene Regulation

The paper creates an explainable map of human gastruloid morphospace to identify failure modes and predict teratogens using drug perturbations and mathematical modeling.

The paper shows that spinal neuron diversity increases exponentially during frog metamorphosis as motor behavior shifts from swimming to limb use, with molecular similarities to mammalian circuits.

This study identifies a time-dependent role for BMP signaling in zebrafish ENS development, showing BMP5 is required for proper enteric progenitor maintenance and GI tract colonization.

This study examines the combinatorial Wnt signaling patterns in brachiopod embryos, identifying conserved and variable gene expression across the anteroposterior axis.

This study identifies T-UCstem1 as a key lncRNA regulating gastruloid development through DKK1-dependent modulation of WNT signaling, affecting anteroposterior axis extension and cellular identity.

This study shows that centralspindlin is essential for cytokinesis during early embryonic divisions but has incomplete requirements in postembryonic development, affecting anchor cell specification and vulva morphogenesis.

This study shows that MYCN overexpression in zebrafish sympathoadrenal progenitors leads to an expanded NCC gene signature and disrupted BMP signaling, contributing to neuroblastoma-like developmental changes.

The paper identifies gene regulatory circuits controlling cranial neural crest migration and plasticity using multi-omics and computational methods.

The paper shows that cell density in the posterior presomitic mesoderm modulates body axis elongation speed through a negative feedback loop, coupling tissue mechanics and FGF activity.

The paper examines how Su(H) affects sog enhancer activity in Drosophila embryos, showing region-specific expression changes when Su(H) is absent.

This study identifies how Hoxa5 interacts with transcription factors and regulates chromatin accessibility to generate motor neuron subtype diversity in mice.

This study uses single-cell tracking to analyze Hes1 dynamics in mouse embryos, revealing distinct oscillation patterns in presomitic mesoderm and preneural tube cells.

This paper identifies a signaling network involving Mnb, Reps, Rlip, and Rala that regulates brain development in Drosophila.

The paper identifies 204 novel genes affecting vertebral development in mice by analyzing whole-gene knockouts from the IMPC dataset and categorizes their phenotypes.

The paper uses a quantum walk model to show that Bicoid gradient interpretation by hunchback occurs within less than a second, aligning with experimental observations.

The paper identifies genes regulated by DMD-3 in C. elegans male tail tip morphogenesis through RNA-seq and validates their expression patterns.

The paper investigates how retinoic acid influences the segregation of dorsal neural fates by analyzing gene expression and lineage markers in developing neural tubes.

This study identifies non-occluding roles of septate junction components in regulating cell polarity and signaling pathways during epithelial development.

The paper investigates proteome and phosphoproteome changes along the dorso-ventral axis of Drosophila embryos, revealing differential regulation and functional roles of proteins and phosphorylation events.

The paper uses quantitative modeling to investigate fate specification in the C. elegans postembryonic M lineage and identifies potential missing spatiotemporal signals.

The paper identifies a novel expression domain of extradenticle in harvestman patella, suggesting that modification of an ancient gene, not neofunctionalization of a new copy, underlies the origin of the chelicerate patella.

The paper traces the evolutionary history of EGF-CFC proteins across species, showing gene expansion, specialization, and chromosomal translocation in mammals.

The paper shows that non-apical mitoses in the mouse gastrulation streak, driven by actomyosin relaxation and accelerated cell cycles, contribute to cell delamination, but not mesoderm identity.

This paper investigates the role of a maternal signal (MUM) in establishing growth axes during kelp embryogenesis, showing that MUM inhibits medio-lateral axis formation and requires direct contact with the stalk.

The paper quantifies Hox gene expression in sea urchin embryos at different developmental stages and finds that certain Hox genes are expressed early, while others increase later, suggesting evolutionary changes in body plan organization.

The paper shows that Dusky-like maintains apical cell expansion, which is critical for corneal lens morphogenesis in Drosophila.

The paper shows Adam13 regulates histone modifications, gene expression, and splicing in cranial neural crest cells by interacting with Arid3a and other proteins.

This study shows that BMP signaling reduces cell adhesion to promote mesenchymal cell migration during fin fold development in zebrafish.

This study shows UNC-30/PITX regulates GABA receptor clustering and biosynthesis in C. elegans motor neurons through transcriptional control of target genes.

This study shows that the size of germline intercellular bridges in fruit fly egg chambers scales based on lineage, with earlier-born bridges growing more slowly.