Developmental Biology and Gene Regulation

The paper identifies Eomes's role in directing the formation of distinct extra-embryonic hematovascular tissues in mice, revealing functional and mechanistic diversity in their development.

This study identifies inppl1a as a gene regulating cell expansion in zebrafish notochord, spine morphogenesis, and endochondral bone lengthening, revealing a conserved mechanism across species.

This study shows that spatial and temporal control of axis segmentation in medaka fish are dissociable modules, identified through devQTL mapping and CRISPR validation.

This study identifies cis-regulatory differences in the Mymk promoter that explain divergent muscle multinucleation patterns between vertebrates and tunicates.

This paper designs soluble multivalent Notch agonists to activate Notch signaling in vitro, enabling T cell differentiation and immunotherapy development.

The paper shows that dimerization activates the Inversin complex in C. elegans, with optogenetic stimulation and genetic studies supporting this mechanism.

The paper traces the embryonic origin of calcitonin-producing cells across vertebrates and finds they derive from pharyngeal endoderm, not neural crest, and identifies homologues in invertebrate chordates.

This study shows that retinoic acid breakdown via CYP26B1 determines positional identity during amphibian limb regeneration, with Shox playing a key role in PD skeletal element formation.

This paper investigates how different Notch ligands contribute to the synchronization of the segmentation clock in zebrafish through two competing hypotheses about Delta ligand interactions.

The study identifies two enhancer elements that maintain En1 expression during later limb development and shows that misexpression timing leads to distinct phenotypes.

This study identifies the transcription factor Cph as promoting intestinal stem cell proliferation and endocrine differentiation in Drosophila, with implications for tumorigenesis and aging.

This study identifies and analyzes Pax7 in lamprey, showing its potential ancestral role and functional similarities to higher vertebrates in metabolic and developmental processes.

This paper demonstrates the use of DsiRNA for functional studies in sea urchin embryos, showing its effectiveness in knocking down genes and analyzing Nodal signaling gradients.

This study shows Myo1G promotes Nodal signaling in zebrafish to control left-right asymmetry through a distinct mechanism from Myo1D.

This paper describes the embryonic development of Lumbricillus sp., a littoral oligochaete, and highlights its potential as a model for annelid development studies.

This paper establishes A. mediterranea as an experimental system for developmental biology by developing in vitro culturing methods and characterizing its nervous system development.

This study investigates the role of DNMT1 in genome regulation during haploid and diploid embryogenesis of Bemisia tabaci, finding that DNMT1 is essential for blastoderm development and that ploidy does not affect developmental timing.

This study identifies the embryonic origins of the zebrafish pectoral girdle, revealing multiple developmental contributions and evolutionary implications for girdle transformation.

The paper integrates multi-omics data to refine the gene regulatory network of the sea urchin posterior gut at the single-cell level.

This study establishes a temporally resolved BMP-dependent transcriptional cascade during human amnion specification using a stem cell model and identifies TFAP2A as a critical regulator.

This study investigates the role of Pax6 in amphioxus CNS development, finding altered gene expression in mutants and supporting a conserved role in brain regionalization.

The paper shows that tissue architecture and receptor binding can explain the transition from local to global morphogen diffusion, without needing additional regulatory mechanisms.

The paper introduces a differentiation waves model to explain developmental processes across species, validated using C. elegans and other organisms.

The paper examines serosal differentiation in beetle embryos using RNAi knockdown, showing dose-dependent phenotypic responses and challenging gene expression-based interpretations of tissue identity.

The paper investigates how zebrafish caudal fin rays regenerate, showing that both external signals and intrinsic memory of positional identity influence regenerative growth and final size.

The paper predicts and categorizes PAX proteins in Lissachatina fulica by analyzing domain structures and phylogenetic relationships.

This study shows that Trim71 deficiency during gastrulation disrupts gene expression, leading to defects in erythropoiesis and vascular development, causing embryonic lethality.

The paper investigates pattern formation in the Drosophila eye using experiments and modeling, revealing a new relay model for propagating oscillations and crystal-like order through pulsatile Notch signaling.

The paper studies early embryonic development in the German cockroach, focusing on gene expression patterns and segmentation dynamics during blastoderm formation.

The paper shows that mutations in cohesin subunits rad21 and stag2b have distinct developmental effects in zebrafish, suggesting independent roles of cohesin quantity and composition in early development.