Developmental Biology and Gene Regulation

The paper investigates the role of C15, Lim1, and Al in the development of male and female Drosophila terminalia, finding sex-specific expression and regulatory interactions.

This study investigates the role of Shh signaling in establishing the dorsal-ventral axis during spinal cord regeneration in Xenopus tropicalis, finding that neural progenitor domains are more sensitive to Shh perturbation during regeneration than in uninjured tissue.

This study shows that Hedgehog signaling repression in teleosts reduces radial bones and promotes fin elaboration by affecting specific skeletal regions in zebrafish.

The paper analyzes single-cell RNA-seq data from sea urchin development to compare larval and adult body plan formation, identifying regulatory gene differences and cell type changes.

This study compares the effects of acute Dorsal level reduction via nuclear export versus degradation on target gene expression in Drosophila embryos.

The paper uses a computational model to show how cell division and fate regulation influence macroscopic cell type patterns in epithelial sheets, revealing different patterns based on signaling and division symmetry.

The paper identifies a mechanism for floor plate formation in the vertebrate neural tube that separates the timing of specification and growth to scale morphogen gradients with tissue size.

This study shows that STAT3 signaling is crucial for tissue expansion during postimplantation mouse development by promoting cell proliferation and differentiation.

The paper shows that stochastic division timing and cell mechanics contribute to robust embryo patterning and morphogenesis in mammals.

The paper identifies transcription factors regulating the development of a unique beetle renal cell type involved in water conservation.

This study investigates the role of HoxA- and HoxD-related clusters in zebrafish pectoral fin development by analyzing mutants with combined gene deletions and finds that their simultaneous deletion causes significant developmental defects.

The paper investigates Elp1's role in trigeminal ganglion development by knocking down Elp1 in chick placode cells, revealing its critical function in ganglion size and neuronal interactions.

This study introduces oncoembryology to identify SoxC transcription factors as regulators of colon development and cancer, showing their role in tumor growth and metastasis.

This study shows that EPHA2 regulates SOX2 expression during human esophageal development using iPSCs and organoids, with EPHA2 inhibition reducing SOX2 levels and organoid formation.

The paper studies symmetry breaking during lateral inhibition in Drosophila, finding that fate divergence occurs at low Sc levels without a prolonged low Sc phase and is corrected by cellular rearrangements.

The paper identifies Amalgam and Neurotactin as molecular mediators of cell-cell communication between leg muscle and tendon precursors in Drosophila.

This study shows that maternal Tdrd6a and Tdrd6c are essential for germplasm stability, germ cell specification, and fertility in zebrafish.

The paper shows that Imp and Syp RNA-binding proteins regulate neuronal elimination through transcription factor codes in Drosophila, with implications for vertebrate neurogenesis.

This study shows Nr5a2 is essential for morula development in mice, as its absence causes embryonic arrest, lineage specification issues, and genome instability.

This study shows that Drosophila histoblasts adjust their proliferation and growth dynamics to compensate for changes in starting tissue size during abdominal development.

The paper identifies novel craniofacial genes associated with jaw divergence in pupfishes by comparing tissue-specific transcriptomes of developing jaws and caudal tails.

The paper shows that BMP4 modulates cell identity in mouse gastruloids, influencing the emergence of different cell types from the primitive streak.

The paper investigates how Shh+ floor plate cells contribute to spinal cord regeneration in axolotls by tracking their fate and analyzing gene expression dynamics.

This study shows that ALG-1, a microRNA argonaute, promotes vulva induction in C. elegans independently of the LET-60 Ras pathway.

This study identifies a conserved Hox-Gbx gene module in the rice coral Montipora capitata that patterns the endo-mesoderm into segments, similar to its role in the sea anemone Nematostella vectensis.

The paper uses single-cell proteomics to show protein asymmetry in mouse blastomeres, independent of RNA expression, revealing a new mechanism for early cell fate determination.

The paper compares Hox gene expression in two larval types of Streblospio benedicti to identify developmental divergence associated with morphological differences.

The paper identifies how environmental changes trigger the differentiation of skin cell progenitors into Nm ionocytes in zebrafish, showing their response to specific ion levels and hair cell activity.

The paper develops a mathematical model to study how Dad and Fused regulate stem cell division in Drosophila, showing their synergistic role in maintaining GSC homeostasis and differentiation.

This study shows that Elavl1 is not required for limb development in mice, as its deletion in limb bud mesenchyme does not cause skeletal abnormalities.